EFFECTIVENESS OF COMBINED SURGICAL AND HORMONAL THERAPY IN TREATMENT OF ENDOMETRIOMAS.

Introduction: Endometrial cyst, or endometrioma, is a specific form of endometriosis that often reveals with severe symptoms and requires ongoing treatment. High rate of recurrence after surgical intervention presents a significant challenge in the management of this disease.

Aim Of The Study: Aim of the study was to determine the effectiveness of combined therapy (surgical and hormonal) of endometrioma in terms of development of recurrences, the rate of pregnancy and change in pain intensity.

COMPARATIVE ANALYSIS OF THE EFFICACIES OF BOTULINOTOXIN A THERAPY AND FRACTIONAL RADIO-FREQUENCY-LIFTING IN THE TREATMENT OF PRIMARY HYPERHYDROSIS.

Hyperhydrosis (HH) is a pathology of eccrine gland which is manifested by excessive sweating on the skin. It has a significant negative impact on an individual's quality of life (QoL). Primary HH is the most common idiopathic condition which is mostly localized.

BRIDGING GAP BETWEEN PRE AND POSTOPERATIVE PROSTATE BIOPSIES: PI RADS CORRELATION WITH FINAL HISTOPATHOLOGICAL DATA.

We aim to define strength of correlation between Prostate Imaging Reporting and Data System (PI RADS) scores of prostate cancer and final histopathological data-postoperative Gleason scores (Gs); apparent diffusion coefficient (ADC) and Gs; to define mean ADC values for each Gleason grade as well. To determine compliance of MRI data in preoperative prostate cancer grading with gold standard-morphological data. 203 consecutive patients suspected for prostate cancer (Pc) on multiparametric MRI, who underwent subsequent preoperative TRUS or MRI/Ultrasound fusion guided biopsies were included to this study prospectively.

SOCIO-ECONOMIC FEATURES OF SEXUALLY TRANSMITTED INFECTIONS AMONG MSM IN GEORGIA.

The aim of our study was to investigate correlation between socio-Economic conditions and prevalence of Sexually Transmitted Infections among gay individuals (men who have sex with men, MSM) in Georgia. The study was conducted in 5 main cities in different regions of Georgia (Tbilisi, Batumi, Kutaisi, Zugdidi, and Telavi). During 2015-2019, social workers, LGBT community and non-governmental organizations (NGOs), conducted screening of MSM for STI, which was achieved by disseminating required information through electronic and print media, resulting in maximum involvement of MSM in screening programs for STI disseminating.

HOMOCYSTEINE LEVEL IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME WITH AND WITHOUT INSULIN RESISTANCE.

Until recent period, hyperinsulinemia and hyperandrogenism were thought to be involved in the pathogenesis of polycystic ovary syndrome (PCOS), however, in recent years several studies reported that hyperhomocysteinemia, which may be associated with insulin resistance, plays important role in the pathogenesis of PCOS. Therefore, hyperhomocysteinemia (HHcy) can be considered as one of the newly identified characteristics of PCOS. The aim of the study was to evaluate homocysteine (Hcy) levels in patients with PCOS with and without insulin resistance.

[GENOMIC VARIABILITY DURING PREGNANCY TRIMESTERS].

The article presents data on the genome status of pregnant women in different trimesters of pregnancy, during the normal course of pregnancy. The variability of ribosomal cystone activation as well as the variability of genome stability (frequencies of chromosomal aberrations and fragile sites) in different trimesters of pregnancy have been studied to detect genome-specific functional variability for each trimester.It was found that the level of genome stability determined by the frequency of chromosomal structural disorders and fragile sites in all three trimesters of pregnancy did not differ significantly from similar rates for non-pregnant healthy women.

ATTACHMENT OF CHRONIC LYMPHOCYTIC LEUKAEMIA CELLS BY AUTOLOGOUS POLYMORPHONUCLEAR NEUTROPHILS MEDIATED BY BISPECIFIC ANTI-CD19/CD64 ANTIBODY.

Chronic lymphocytic leukemia (CLL) is the most common adult leukaemia in the US and in Europe, including Georgia. CLL presents with clonal expansion and accumulation of CD5+CD19+CD23+ cells in peripheral lymphoid organs and tissues and in bone marrow. The disease remains incurable, albeit there are new molecular and immunotherapy methods currently available, which, in conjunction with chemotherapy, lead to the "precision therapy" approach.

CHANGES IN ARTERIOLE REACTIVITY TO NORADRENALINE UNDER CONDITIONS OF HYPERHOMOCYSTEINEMIA.

The aim of the research was the experimental study of one of the possible mechanisms performing contractile activity of arterioles in hyperhomocysteinemic animals. Moderate hyperhomocysteinemia was induced in male rats (120-160 g., n=12) by adding L-methionine to the drinking water during 4 weeks.

MODULATION OF ANTITUMOR IMMUNE RESPONSE IN MOUSE PROSTATE CANCER MODEL.

Aim of study - prostate cancer is second most common cancer in men worldwide, and fifth leading cause of death from cancer in men (6.6% of the total men deaths). Unfortunately, once cancer spreads outside of prostate, it becomes incurable.

SUCCESSFUL REPAIR OF IATROGENIC URETERAL INJURY IN A PATIENT WITH ECTOPIC CROSSED AND FUSED RIGHT KIDNEY BY URETEROURETEROSTOMY.

Congenital renal malformations are the most common congenital malformations in humans, the most common being horseshoe kidney with joined lower poles present in up to 0.25% of general population. To the contrary renal fusions with ectopia are amongst the rare malformations affecting 1 in 2000 examined cadavers.

Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line.

Chronic Lymphocytic Leukemia (CLL) presents with clonal expansion and accumulation of CD5+CD19+CD23+ cells in peripheral lymphoid organs and tissues and in bone marrow. CLL is supposedly driven by exogenous and/or endogenous (auto)antigen(s) and there is increasing evidence that CLL cells receive microenvironmental signals which support their growth, survival and expansion in vivo. We have previously shown that powerful signals are received by CLL cells through CD180 orphan toll-like receptor.