FATIGUE IN PATIENTS WITH LONG COVID.

Purpose of the study - to characterize the metabolomic profile in patients with fatigue developing within the Long COVID, during dynamic observation. 24 patients diagnosed with U09.9 "Condition after COVID-19 unspecified" were included in a prospective study.

SCIENCE-BASED APPROACH TO THE EXPERIMENTAL DEVELOPMENT OF A BIODEGRADABLE CHITOSAN BASED CARRIER.

The aim of the study was to develop a science-based approach to the development of a carrier of a pharmaceutical substance using the modification of chitosan. Studies were carried out to determine the upper limit of acidity - ascorbic and acetic to obtain salt forms of chitosan, the choice of modification of chitosan and the experimental development of a method for obtaining its solid salt form. A scientifically based approach to research has made it possible to develop a technology for obtaining a water-soluble biodegradable carrier based on salt forms of chitosan.

EFFECT OF SMOKING STEAM COCKTAILS ON THE HARD TISSUES OF THE ORAL CAVITY.

The aim of the research was to study the impact of smoking steam cocktails on dental status. The study of dental status was carried out by means of a questionnaire, a detailed survey and a clinical examination of patients. The questionnaire was used to determine the level of evaluation of motivation to quit smoking.

[NON-SURGICAL ASPECTS OF THYROID SURGERY].

The level of calcium in the blood serum, voice function, thyroid status and quality of life of patients up to 1 year after removal of the thyroid gland were studied. Thyroidectomy is an operation associated with a high risk of postoperative hypocalcemia with clinical manifestations (19.6%), which is transient in 15.

TRANSFORMING GROWTH FACTOR AND ARTERIAL STIFFNESS IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION.

The aim of our study was to identify the relationship between TGF-β1, arterial stiffness, and target organ damage in patients with uncontrolled arterial hypertension (UAH). The study included 140 patients with hypertension: 30 people with uncontrolled hypertension (UAH), 80 people with controlled hypertension (CAH) and 30 people in the control group. All patients underwent determination of arterial stiffness using cardio-ankle vascular index (CAVI) and TGF-β1 level.

A STUDY OF THE PREVALENCE OF NON-CARIOUS DENTAL LESIONS RELATED TO PRODUCTION FACTORS IN RESIDENTS OF THE CITY OF PENZA.

The aim of the study was to study the current problems of non-carious dental lesions in residents of Penza, depending on the influence of production factors. In the structure of non-carious lesions, there is a large group of diseases (and injuries) of the hard tissues of the teeth (enamel, dentin, cement), which have their various clinical manifestations, the occurrence and development of which is not directly related to the microbial factor, unlike carious lesions. Such diseases are enamel and dentin hypoplasia, fluorosis, wedge-shaped defect, etc.

PECULIARITIES OF ACID PRODUCTION AND PATHOGENESIS OF PYLORIC AND PREPYLORIC GASTRIC ULCER COMPLICATIONS.

The purpose of the study was to identify the pathogenesis features of prepiloric and pyloric ulcers and to establish the cause of resistance to conservative therapy and the tendency to complicated course of type III ulcers according to H.D. Johnson.

[EVALUATION OF DYNAMIC TELOMERE LENGTH SHORTENING OF LYMPHOCYTES IN IMMUNOCOMPROMISED CHILDREN WITH CHRONIC DISEASES OF THE RESPIRATORY].

Nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (DL), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. The conducted study has shown the shortening of telomere lymphocytes in children with CDRT seropositive for mixed-herpes viral infections (herpes simplex virus, virus, Epstein-Barr virus and cytomegalovirus in various combinations) and for bacterial co-infections - Chlamydia trachomatis and (or) Mycoplasma pneumoniae. The use of regression analysis and attribute analysis (in percent) made possible to neutralize age-groups differences of seropositive and seronegative children.

[Proton Transfer Reaction Mass Spectrometry of Exhaled Breath in Diagnostics of Heart Failure].

Exhaled breath analysis is one of directions in the search for novel biomarkers of chronic heart failure (CHF). According.

Toxic and Immunomodulatory Properties of an Iron(II) Coordination Complex of Isoleucyltryptophan Dipeptide.

Results from toxicological and pharmacological studies of the iron(II) coordination complex of the immunoactive dipeptide isoleucyltryptophan (timofer) were presented. It was established that timofer was practically nontoxic and exhibited high immunostimulatory activity when combined with viral and bacterial vaccines.