1 results match your criteria: "1Buck Institute for Research on Aging[Affiliation]"
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
NPJ Aging Mech Dis
October 2019
1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400 USA.
Article Synopsis
- Aging leads to a decline in physiological functions across all organisms, but environmental factors like diet can influence this process.
- The compound nordihydroguaiaretic acid (NDGA) has been shown to increase lifespan in both flies and mice, although its exact mechanism of action is not well understood.
- Research reveals that NDGA inhibits the p300 epigenetic regulator, blocking its acetyltransferase activity and promoting autophagy, which helps explain how NDGA may contribute to increased longevity.