Bench-Stable 2-Halopyridinium Ketene Hemiaminals as Reagents for the Synthesis of 2-Aminopyridine Derivatives.

2-Chloro-1-(1-ethoxyvinyl)pyridinium triflate and several other bench-stable -(1-alkoxyvinyl) 2-halopyridinium triflates have been developed as reagents for the synthesis of valuable 2-aminopyridine scaffolds via unusually mild SAr substitutions with amine nucleophiles. Advantages of this approach include an operationally simple mix-and-stir procedure at room temperature or mild heat and ambient atmosphere and without the need for transition metal catalysts, coupling reagents, or high-boiling solvents. The stable -(1-ethoxyvinyl) moiety serves as a dual SAr-activating group and pyridine -protecting group that can be cleaved under thermal, acidic, or oxidative conditions.

Do social media use and patient satisfaction scores correlate with online award recognition among hip and knee arthroplasty specialists?

Introduction: The physician-patient interaction now begins before patients arrive in the office. Online ratings, social media profiles, and online award status are all components of physician online reputation which contributes to the patient's initial impressions. Therefore, it is important to understand the interplay of these factors and determine if there is a consistent trend indicating the value of this information.

Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda.

The zinc-finger protein Zelda (Zld) is a key activator of zygotic transcription in early Drosophila embryos. Here, we study Zld-dependent regulation of the seven-striped pattern of the pair-rule gene even-skipped (eve). Individual stripes are regulated by discrete enhancers that respond to broadly distributed activators; stripe boundaries are formed by localized repressors encoded by the gap genes.

A Case of Fungemia Caused by Postoperative Chronic Lumbar Intervertebral Disc Infection.

Postoperative surgical site infection is one of the serious postoperative complications of spine surgery, especially fungal infections. Late-stage surgical site fungal infections often lack typical clinical symptoms and have a variable clinical presentation. In this case, the patient was a senior patient with usually only tolerable pain and discomfort, which was detected 2 years after the first surgery.

COVID-19 bereavement, depressive symptoms, and binge drinking.

The COVID-19 pandemic has caused the death of over half a million Americans, leaving in its wake widespread grief and despair. Using national survey data (n ​= ​1998) and a treatment-weighting strategy, this study examines how COVID-19 bereavement associates with depressive symptoms and binge drinking. After adjustment for non-random exposure to COVID-19 bereavement, I find that respondents who have lost someone close to them to the virus report greater depressive symptomology and more frequent binge drinking.

Synthesis of Bench-Stable Quaternized Ketene ,-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis.

-Quaternized ketene ,-acetals are typically an unstable, transient class of compounds most commonly observed as reactive intermediates. In this report, we describe a general synthetic approach to a variety of bench-stable -quaternized ketene ,-acetals via treatment of pyridine or aniline bases with acetylenic ethers and an appropriate Brønsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate). The resulting pyridinium and anilinium salts can be used as reagents or synthetic intermediates in multiple reaction types.

Mosquito blood-feeding patterns and nesting behavior of American crows, an amplifying host of West Nile virus.

Background: Although American crows are a key indicator species for West Nile virus (WNV) and mount among the highest viremias reported for any host, the importance of crows in the WNV transmission cycle has been called into question because of their consistent underrepresentation in studies of Culex blood meal sources. Here, we test the hypothesis that this apparent underrepresentation could be due, in part, to underrepresentation of crow nesting habitat from mosquito sampling designs. Specifically, we examine how the likelihood of a crow blood meal changes with distance to and timing of active crow nests in a Davis, California, population.

The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease.

Epilepsy not-otherwise-specified (ENOS) is one of the most common causes of chronic disorders impacting human health, with complex multifactorial etiology and clinical presentation. Understanding the metabolic processes associated with the disorder may aid in the discovery of preventive and therapeutic measures. Post-mortem brain samples were harvested from the frontal cortex (BA8/46) of people diagnosed with ENOS cases ( = 15) and age- and sex-matched control subjects ( = 15).

Parting ways: Sex-based differences in premedical attrition.

Despite women's greater propensity to enter college aspiring to careers in medicine, they are less likely than men to persist in these ambitions. Past research suggests that students' experiences in coursework strongly influence their decision to continue along or depart from the premedical track, yet it remains unclear whether women and men have differential experiences in coursework that contribute to sex-based disparities in premedical attrition. To gain insight into whether and how premeds' experiences in coursework contribute to gendered patterns of attrition, this study employs a mixed methods design that combines longitudinal survey data collected from premedical students at a large state university with in-depth interview data collected from a subset of respondents.

Friend or frenemy? Experiential homophily and educational track attrition among premedical students.

Support from experientially similar others-individuals who have been through the same life transition or faced a similar set of stressful circumstances-has been shown to be effective for coping with issues ranging from chronic illness to bereavement. Less research has examined how networks comprised of experientially similar others may shape academic outcomes. Using longitudinal egocentric network data collected from early career premedical students at a large research university (n = 268), results indicate that greater experiential homophily in premeds' networks are associated with a lower likelihood of departing from the premedical career track at the end of the academic year.

Subjective social status and premedical students' attitudes towards medical school.

Although students from lower socioeconomic backgrounds are more likely to depart from the medical education pipeline, little is known about how premedical students' social origins influence the adversities they face, the resources they possess, or the internal struggles they confront in deciding whether or not to pursue a career in medicine. Using original data collected from premedical students at a flagship state university in the Midwest (N = 364), this study explores how subjective social status shapes students' reservations about medical school attendance and their perceptions of external pressure to pursue a career in medicine. Status-based discrepancies in financial strains, social capital, and interpersonal stressors-and the degree to which variation across these measures mediates status differences in medical school outlook-are also explored.

Climate effects on late-season flight times of Massachusetts butterflies.

Although the responses of living organisms to climate change are being widely investigated, little attention has been given to such effects late in the growing season. We studied the late-season flight times of 20 species of butterflies in a geographically limited region, the state of Massachusetts in the USA, by examining change in dates of flight over a 22-year period and in response to average monthly temperature and precipitation. By analyzing the last 10% of each year's observations reported by observers of the Massachusetts Butterfly Club, we found that seven species remain in flight significantly later into the fall than they did two decades earlier, while two species show reduced late-season flight.

Engineering the biological conversion of methanol to specialty chemicals in Escherichia coli.

Methanol is an attractive substrate for biological production of chemicals and fuels. Engineering methylotrophic Escherichia coli as a platform organism for converting methanol to metabolites is desirable. Prior efforts to engineer methylotrophic E.

Root development and structure in seedlings of Ginkgo biloba.

Premise Of The Study: The popular, highly recognizable, well-known gymnosperm, Ginkgo biloba, was studied to document selected developmental features, which are little known in its primary root system from root tips to cotyledonary node following seed germination.

Methods: Using seedlings grown in soil, vermiculite, or a mixture, we examined sections at various distances from the root cap to capture a developmental sequence of anatomical structures by using standard brightfield, epifluorescence, and confocal microscopic techniques.

Key Results: The vascular cylinder is usually a diarch stele, although modified diarchy and triarchy are found.

The roles of gender and temporal distance in the recall of dissonant self-related memories.

This study examined strategies employed to support a positive self-image in the face of dissonant self-related memories, especially focusing on the role of gender. Participants (N=498) were recruited online and identified a self-descriptive trait. They then reported a memory of a time when they did or did not act according to that trait.

A low cost multi-level sampling device for synchronous aseptic collection of environmental water samples.

We describe a simple device for the aseptic collection of environmental water samples at high spatial resolution to depths of 50m. To demonstrate the utility of this technique we present geochemical and archaeal community data from samples collected throughout the water column of a stratified lake.

Urothelial differentiation of human amniotic fluid stem cells by urothelium specific conditioned medium.

Human amniotic fluid stem cells (HAFSCs) have a high proliferative capacity and a good differentiation potential, and may thus be suitable for regenerative medicine. To date, urothelial differentiation mechanisms of HAFSCs are poorly understood. We have investigated the urothelial differentiation potential of HAFSCs so that they can be therapeutically applied to cure defective diseases of bladder.

Does suppressing the thought of a self-relevant stigma affect interpersonal interaction?

In the current study, we examined the effects of women's suppressing negative gender stereotypes while interacting with a male confederate. Compared with control participants, those who suppressed negative thoughts about women's ability experienced less self-confidence, lower self-esteem, and were more nonverbally submissive during the interaction, particularly if they were high in stigma consciousness (Pinel, 1999). These findings illustrate the negative intra- and interpersonal consequences of stigma suppression.

Deeper processing at target selection increases the magnitude of negative priming.

Do deeper levels of processing produce equivalent priming effects at all stages of task performance? In Experiment 1, we varied the level of processing factorially across two task stages--target selection and response selection. Each stage required perceptual (e.g.