1 results match your criteria: "1385 Center Avenue[Affiliation]"
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Nat Struct Mol Biol
October 2008
Department of Biochemistry and Molecular Biology, Colorado State University, 1870 Campus Delivery, 1385 Center Avenue, Fort Collins, Colorado 80523-1870, USA.
Article Synopsis
- Histone methylation plays a crucial role in regulating chromatin function by influencing the chromatin structure and creating specific binding sites for proteins.
- Researchers studied the crystal structures of nucleosomes with methylated histones to understand how these modifications affect chromatin folding.
- Specifically, dimethylation of histone H3 at lysine 79 changes the nucleosome's immediate surface, while trimethylation of H4 at lysine 20 impacts the arrangement of nucleosome arrays at a higher level.