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Preventing phagocytosis takes more than a sweet disposition.
Cell Host Microbe
March 2011
Department of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University of Wisconsin, Madison, WI 53706, USA; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University of Wisconsin, Madison, WI 53706, USA. Electronic address:
While a polysaccharide capsule is known to be important for preventing phagocytosis of the human pathogen Cryptococcus neoformans, other antiphagocytic pathways have been generally elusive. Now, a capsule-independent pathway has been identified that prevents macrophages from ingesting the fungus, contributing to evasion of the host immune response.
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