5 results match your criteria: "12487Anhui University[Affiliation]"
Electrically Evoked Auditory Brainstem Responses in Children Fitted with Hearing Aids Prior to Cochlear Implantation.
Trends Hear
January 2023
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
This study investigates the effect of hearing aid use on the peripheral auditory pathways in children with sensorineural hearing loss prior to cochlear implantation, as revealed by the electrically evoked auditory brainstem response (EABR). Forty children with hearing aids were recruited. Half of them had normal inner ear structures and the other half had inner ear malformations (IEMs).
View Article and Find Full Text PDFCarrier-free prodrug nanoparticles based on lonidamine and cisplatin for synergistic treatment of breast cancer.
J Biomater Appl
October 2022
Engineering Research Center for Biomedical Materials, School of Life Science, Anhui Key Laboratory of Modern Biomanufacturing, 12487Anhui University, P. R. China.
Herein, we combined a derivative of cisplatin (CP) and the chemosensitizer lonidamine (LND) to design an amphiphilic prodrug, in which the ratio of LND to cisplatin was fixed at 2:1. Diaminedichlorodihydroxyplatinum (DH-CP) is a hydrophilic cisplatin derivative. Due to its appropriate amphiphilicity, this prodrug could self-assemble into stable nanoparticles (denoted as LNP-NPs).
View Article and Find Full Text PDFClinical Target Volume Auto-Segmentation of Esophageal Cancer for Radiotherapy After Radical Surgery Based on Deep Learning.
Technol Cancer Res Treat
February 2022
College of Computer Science and Technology, 12487Anhui University, Hefei, Anhui, China.
Article Synopsis
- Radiotherapy is crucial for controlling esophageal cancer recurrence post-surgery, with clinical target volume (CTV) segmentation being a vital but time-consuming step in treatment planning.
- The study presents a deep dilated convolutional U-network that automates CTV segmentation, combining benefits of dilated convolution and U-net to enhance speed, accuracy, and reduce information loss.
- Results showed an overall mean Dice similarity coefficient of 86.7% and a segmentation time of about 25 seconds per patient, making it a promising tool for improving efficiency and consistency in clinical practice.
Self-assembled 5-fluorouracil-cinnamaldehyde nanodrugs for greatly improved chemotherapy in vivo.
J Biomater Appl
October 2021
School of Life Science, 12487Anhui University, Hefei, China.
The preferred cancer treatment is to achieve a high therapeutic effect as well as reduce side effects. In this study, we developed carrier-free nano drugs based on 5-fluorouracil (5FU) and cinnamaldehyde (CA) to meet the above goals. Two model drugs were spliced by acetal linkage and ester bond, which could self-assemble into nano drug particles (5FU-CA NPs) with a size of ∼170 nm.
View Article and Find Full Text PDFChemosensitizing micelles self-assembled from amphiphilic TPGS-indomethacin twin drug for significantly synergetic multidrug resistance reversal.
J Biomater Appl
March 2021
Engineering Research Center for Biomedical Materials, School of Life Science, Anhui Key Laboratory of Modern Biomanufacturing, 12487Anhui University, Hefei, China *Equal contributors.
Vitamin E d-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS) and indomethacin (IDM) can reverse multidrug resistance (MDR) via inhibiting P-glycoprotein (P-gp) and multidrug resistance associated protein 1 (MRP1) respectively, but their drawbacks in physicochemical properties limit their clinical application. To overcome these defects and enhance MDR reversal, the amphiphilic TPGS-IDM twin drug was successfully synthesized via esterification, and could self-assemble into free and paclitaxel-loaded (PTX-loaded) micelles. The micelles exhibited lower CMC values (5.
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