18 results match your criteria: "12485Anhui Medical University[Affiliation]"
Technol Cancer Res Treat
January 2023
74639Beijing Chaoyang Hospital of Capital Medical University, Beijing, China.
Lymph node downstaging and the achievement of total-pCR (ypT0/is ypN0) after neoadjuvant therapy are of great importance in HER-2 positive breast cancer. We aim to provide an overall review of neoadjuvant regimens for lymph node downstaging and to indirectly compare the total-pCR by various neoadjuvant regimens with network meta-analysis in HER2-positive patients according to their clinical lymph node status. Five English databases were searched comprehensively and systematically for relevant RCTs and case-control studies.
View Article and Find Full Text PDFKnee Osteoarthritis (KOA), is the most common joint disease worldwide. The pathogenesis of KOA is complex and electroacupuncture (EA) is an effective therapy for KOA, but the mechanism remains unclear. In this study, we aim to investigate the potential therapeutic effect of EA on the rat model of KOA induced by monosodium iodoacetate (MIA) and its relationship with NLRP3 inflammasome by immunohistochemistry and western blot.
View Article and Find Full Text PDFLupus
February 2023
School of Nursing, 12485Anhui Medical University, Hefei, Anhui, China.
Background: Self-disclosure may enhance positive illness perceptions, whereas patients with systemic lupus erythematosus (SLE) always facing negative illness perceptions due to multiple reasons, so elucidation of factors affecting self-disclosure may facilitate the development of quality of life.
Methods: A total of 161 hospitalized patients with SLE were recruited. Scales on demographic and clinical characteristics, self-disclosure, psychosocial status (e.
Lupus
December 2022
Department of Epidemiology and Biostatistics, School of Public Health, 12485Anhui Medical University, Hefei, China.
Objective: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients.
Methods: Initially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case-control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL.
Int J Biol Markers
September 2022
12485Anhui Medical University, Hefei, China.
Background: ) participates in tumor resistance by playing the function of homologous recombination repair(HRR). However, the role of in non-small cell lung cancer (NSCLC) is still unclear. This study aims to understand the expression of in NSCLC and preliminarily explore its relationship with cisplatin resistance.
View Article and Find Full Text PDFToxicol Ind Health
May 2022
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
The mechanism of kidney injury in occupational medicamentosa-like dermatitis due to trichloroethylene exposure is not well understood. This study aimed to investigate the role of endothelin-1 (ET-1)/vascular endothelial-derived growth factor-A (VEGF-A) in trichloroethylene (TCE)-induced renal injury. Forty BALB/c female mice were used in this study to build the TCE-sensitization mouse model.
View Article and Find Full Text PDFJ Interpers Violence
January 2023
Department of Maternal, Child and Adolescent Health, School of Public Health, 12485Anhui Medical University, Hefei, China.
A history of child sexual abuse (CSA) is associated with a variety of psychological issues and conduct disorders in adolescents. However, little is known about the association between CSA and its characteristics and murderous behaviors in young adults. The purpose of this study was to examine this relationship and explore the mediating effect of psychological adjustment (PA).
View Article and Find Full Text PDFJ Int Med Res
March 2022
Department of Vascular Surgery, 117555Beijing Hospital, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Graduate School of Peking Union Medical College, Beijing, P.R. China.
Objective: Atherosclerosis (AS) is a life-threatening disease in aging populations worldwide. However, the molecular and gene regulation mechanisms of AS are still unclear. This study aimed to identify gene expression differences between atheroma plaques and normal tissues in humans.
View Article and Find Full Text PDFInt J Biol Markers
March 2022
Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, PR China.
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which play critical roles in cancer progression and metastasis. In recent years, many researchers have been studying the relationship between MMP9 and breast cancer. However, it still remains indecisive.
View Article and Find Full Text PDFHum Exp Toxicol
December 2021
Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, School of Pharmacy, 12485Anhui Medical University, Hefei, China.
Triptolide (TP), the main active compound extracted from medicine- (TWHF). It has anti-tumor and immunomodulatory properties. Our study aimed to investigate the mechanisms of hepatotoxicity treated with TP as well as their relationship with the NF-κB (p65) signal pathway; and to assess TP-induced hepatotoxicity after CYP2E1 modulation by the known inhibitor, clomethiazole, and the known inducer, pyrazole.
View Article and Find Full Text PDFJ Int Med Res
October 2021
Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Objective: To evaluate the prevalence of type 2 diabetes mellitus (T2DM) with chronic kidney disease (DM-CKD) and identify the associated factors in patients attending primary hospitals in Anhui Province, China.
Methods: A multi-stage sampling method was used to collect the demographic information, general clinical data, and details of the kidney disease of patients in 2019 through a questionnaire survey, physical examination, and laboratory examination.
Results: A total of 1067 patients with T2DM were studied, of whom 345 had chronic kidney disease (CKD; 32.
J Interpers Violence
November 2022
Department of Maternal, Child & Adolescent Health, School of Public Health, 12485Anhui Medical University, Hefei, China.
Investigations have found maternal adverse childhood experiences (ACEs) cause an intergenerational danger to their children's health. However, no study has investigated the effects of maternal ACEs on behavioral problems of preschool children in China and gender differences on these effects. This paper aims to investigate the role of maternal ACEs on behavioral problems of preschool children in China and explore gender differences as related to these behavioral problems.
View Article and Find Full Text PDFHum Exp Toxicol
December 2021
Experimental Teaching and Learning Center, 12485Anhui Medical University, Hefei, China.
Resveratrol has been reported as an ideal medicine in the treatment of colorectal cancer. Meanwhile, cadmium could affect the occurrence and development of tumors in various ways. Epithelial-mesenchymal transition is a major progress regulated with colorectal cancer (CRC).
View Article and Find Full Text PDFLupus
October 2021
Department of Epidemiology and Biostatistics, School of Public Health, 12485Anhui Medical University, Hefei, China.
Hum Exp Toxicol
July 2021
Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, School of Pharmacy, 12485Anhui Medical University, Hefei, China.
Liver cancer is a malignant cancer with great harmfulness. Fenofibrate is a peroxisome proliferation activated receptor (PPARα) agonist widely used in the treatment of dyslipidemia. Previous studies have shown that fenofibrate may promote cell proliferation, but the underlying mechanism has not been fully characterized.
View Article and Find Full Text PDFCell Transplant
December 2021
Department of Orthodontics, Stomatologic Hospital & College, 12485Anhui Medical University, Key Lab of Oral Diseases Research of Anhui Province, Hefei, P. R. China.
The lack of vasculogenesis often hampers the survivability and integration of newly engineered tissue grafts within the host. Autologous endothelial cells (ECs) are an ideal cell source for neovascularization, but they are limited by their scarcity, lack of proliferative capacity, and donor site morbidity upon isolation. The objective of this study was to determine whether differentiation of human dental pulp stem cells (DPSCs) into the endothelial lineage can be enhanced by recombinant ETV2 overexpression.
View Article and Find Full Text PDFJ Int Med Res
November 2020
Department of Neurology, The Affiliated Hefei Hospital of 12485Anhui Medical University, Hefei, Anhui, P.R. China.
Anton's syndrome is a rare neuropsychiatric syndrome that is characterized by cortical blindness and anosognosia with visual confabulation, but without global cognitive impairment. We herein report a rare case of Anton's syndrome as a presentation of Trousseau syndrome involving the bilateral optic radiation. The patient had been diagnosed with gallbladder cancer 2 months previously, and he was admitted to the hospital with confusion and quadriplegia.
View Article and Find Full Text PDFTechnol Cancer Res Treat
November 2021
Department of Otorhinolaryngology, Head and Neck Surgery, 36639The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
The objective of this study was to investigate the between autophagy activity and local immune response in hypopharyngeal squamous cell carcinoma (HSCC). Herein, we observed the expression of autophagy marker microtubule-associated protein light chain 3B (MAP1LC3B), CD8 cytotoxic T lymphocytes (CTLs), CD39 (regulatory T cells Tregs) and CD163 (tumor-associated macrophages TAMs) in HSCC, and determined the prognostic roles of CD8/CD39 and CD8/CD163 in patients with HSCC. The expression of light chain 3B (LC3B) and CD8/CD39 was found to be significantly lower in HSCC tissues than in adjacent non-tumor mucosa tissue samples; LC3B expression was positively correlated with the infiltration rate of CD8/CD39 in HSCC.
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