LncRNA colorectal neoplasia differentially expressed exacerbates the impairments in learning and memory induced by isoflurane.

Background: This observation aimed to investigate the effect of colorectal neoplasia differentially expressed (CRNDE) targeted miR-212-5p on cognitive impairment induced by isoflurane (ISO) anesthesia in rats.

Methods: The cognitive function of rats was measured by Morris water maze test. QRT-PCR detection of CRNDE and miR-212-5p expression levels in rats in each group.

Crack detection for concrete bridges with imaged based deep learning.

Within the framework of intelligent bridge detection, a number of crack detection methods based on image processing techniques have been implemented. In this study, a combined novel approach with deep learning of a single shot multibox detector (SSD) and the eight neighborhood algorithm is proposed and applied to bridge crack image identification to provide an automatic method for crack detection. First, a large number of concrete crack images collected from the site were segmented and preprocessed for the establishment of a crack image dataset.

Effect of LncRNA OIP5-AS1/microRNA-186-5p on isoflurane-induced cognitive dysfunction in aged rats.

Background: Post-operative recognition dysfunction (POCD) is a kind of central nervous system complication that appears after operative anesthesia. Recent studies on the mechanism of long non-coding RNA (lncRNA) in neurodegenerative diseases are abundant.

Aims: The study aimed to explore the expression pattern and role of lncRNA OIP5-AS1 in POCD and to investigate its underlying mechanism in old rats.

Integrating model explanations and hybrid priors into deep stacked networks for the "safe zone" prediction of acetabular cup.

Background: Existing state-of-the-art "safe zone" prediction methods are statistics-based methods, image-matching techniques, and machine learning methods. Yet, those methods bring a tension between accuracy and interpretability.

Purpose: To explore the model explanations and estimator consensus for "safe zone" prediction.

Ankle joint pressure change before and after subtalar joint arthrodesis in varus and valgus malalignment of the tibia.

The compensation mechanism of subtalar joint in ankle with varus or valgus deformity is controversial and not well established. This biomechanical study aims to investigate how subtalar joint arthrodesis will affect the ankle joint pressure in varus and valgus malalignment of the tibia. Eight fresh-frozen human cadaver legs were tested in this study.

Research on Modeling and Simulation of Fuel Cell Bus Power System Based on Forward-Backward energy flow balance method.

The modeling and simulation research of fuel cell buses' power system is an important part of accelerating the process of industrialization. This paper firstly analyzes the advantages and disadvantages of different topologies of power systems to determine the optimal configuration, then conducts the parameter matching study of the power system, derives and determines the main vehicle dynamics parameters and the total power demand of the power system, and further completes the parameter matching of the drive motor, gear ratio and power supply, as well as the design of the fuel cell stack. On the Matlab/Simulink platform, the forward-backward energy flow balance method is used to establish a fuel cell power system model divided into power calculation modules and power shunt modules.

Research on innovative plug-in hybrid electric vehicle comprehensive energy consumption evaluation method based on statistic energy consumption.

The plug-in hybrid electric vehicle not only has the advantages of low emissions from electric vehicles, but also takes advantage of the high specific energy and high specific power of petroleum fuels, which can significantly improve the emissions and fuel economy of traditional vehicles. Studying its comprehensive energy consumption evaluation method is an important part of analyzing the economics of plug-in hybrid electric vehicles. This paper first puts forward the concept of statistical energy consumption and then proposes an innovative calculation method of plug-in hybrid electric vehicle energy consumption based on statistical energy consumption by referring to and analyzing the energy consumption test regulations of the United States, the European Union, and China.

A duodenal ampullary tumor with malignant transformation of papillary polyps: a case report and literature review.

Periampullary carcinoma refers to a malignant tumor within 2 cm of the duodenal ampulla. Primary ampullary carcinoma is very rare, accounting for only 0.2% of malignant gastrointestinal tumors.

Cerebral Hemodynamic Responses to the Difficulty Level of Ambulatory Tasks in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis.

. Ambulatory tasks are the important components of balance training which effectively improve postural stability and functional activities in persons with Parkinson's disease (PD). The difficulty level of an ambulatory task is usually set in the form of attention, direction, speed, or amplitude requirement.

Impact of corrected sinus node recovery time in predicting recurrence in patients with paroxysmal atrial fibrillation.

Objective: Atrial fibrillation (AF) and sinus node dysfunction (SND) have common underlying pathophysiological mechanisms. As an index of SND, corrected sinus node recovery time (CSNRT) may also reflect atrial function. The aim of the present study was to determine whether CSNRT predicts AF recurrence in patients undergoing AF ablation.

Benefits of Indirect Contact With Nature on the Physiopsychological Well-Being of Elderly People.

Objectives: Exposure to nature or to green space has positive mental health benefits. Closing of parks and green spaces during the COVID-19 pandemic has reduced options for mental health and well-being benefits and could have a greater impact on vulnerable populations, especially the elderly. The present study, therefore, explores the physiopsychological impacts of indirect contact with nature, using forest imagery, on the brain activity and autonomic nervous systems of elderly people.

Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice.

The present study was aimed to evaluate the chemopreventive potential of galangin against benzo(a)pyrene (BaP)-induced stomach carcinogenesis in Swiss albino mice. Stomach cancer was induced in experimental mice using BaP oral administration. The mice were treated with galangin (10 mg/kg b.

Noise in Maternity Wards: A Research on Its Contributors and Sources.

Aims: This research aimed to investigate the major user behavior patterns of noise sources in healthcare environments and summarize such information as evidence that can inform the design of maternity wards for indoor noise control and patients' well-being.

Methods: Field investigations were conducted to identify users' behaviors as the major contributors of noises in the maternity wards of a typical hospital. A control experiment was set to test the feasibility of a noise control system that consisted of smart bracelets, mobile terminals, and monitors.

Power and Promise of Next-Generation Sequencing in Liquid Biopsies and Cancer Control.

Traditional methods of cancer treatment are usually based on the morphological and histological diagnosis of tumors, and they are not optimized according to the specific situation. Precision medicine adjusts the existing treatment regimen based on the patient's genomic information to make it most suitable for patients. Detection of genetic mutations in tumors is the basis of precise cancer medicine.

New Therapeutic Options for Advanced Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC), one of the most common lethal diseases in the world, has a 5-year survival rate of only 7%. Hepatocellular carcinoma has no symptoms in the early stage but obvious symptoms in the late stage, leading to delayed diagnosis and reduced treatment efficacy. In recent years, as the scope of HCC research has increased in depth, the clinical development and application of molecular targeted drugs and immunotherapy drugs have brought new breakthroughs in HCC treatment.

Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?

Background: Walk-up buildings are common in China today since they were almost the only type of residential buildings constructed from the 1950s to the 1990s.

Objectives: This study examined how a vertical mobility obstacle, that is, mandatory stair climbing in walk-up residential buildings, may impact whether seniors go outdoors.

Methods: We collected and examined 1,608 valid data records from 64 Chinese senior participants in Shanghai wearing Fitbit HR wristbands that tracked their mobility and physical activity for 31 consecutive days.