Methamphetamine exposure increases cardiac microvascular permeability by activating the VEGF-PI3K-Akt-eNOS signaling pathway, reversed by Bevacizumab.

Methamphetamine (METH) is an illicit amphetamine-like psychostimulant that is commonly abused. However, the modulation of METH-induced cardiac microvascular permeability is still not completely known. Previously, we discovered that the vascular endothelial growth factor (VEGF) regulated the cardiotoxicity produced by METH.

System analysis of in LUAD and LUSC: The expression, prognosis, gene regulation network, and regulation targets.

Background: Fragile histidine triad () is a strong tumor suppressor gene, and cells deficient in are prone to acquiring cancer-promoting mutations. Due to its location, deletions within are common in cancer. Over 50% of cancers show loss of expression.

System analysis of in renal cell carcinoma: The expression, prognosis, gene regulation network and regulation targets.

Background: VEGFA is one of the most important regulators of angiogenesis and plays a crucial role in cancer angiogenesis and progression. Recent studies have highlighted a relationship between expression and renal cell carcinoma occurrence. However, the expression level, gene regulation network, prognostic value, and target prediction of in renal cell carcinoma remain unclear.