Exposure to pesticides and pediatric Wilms' tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary.

Background: There are hereditary types of nephroblastoma or Wilms' tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms' tumor.

Methods: A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms' tumor occurrence in children rigorously.