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LncRNA RHPN1-AS1 Promotes Cell Proliferation, Migration and Invasion Through Targeting miR-7-5p and Activating PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma.
Technol Cancer Res Treat
November 2021
117842Weihai Municipal Hospital of Dalian Medical University, Weihai, Shandong, People's Republic of China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious form of liver cancer with high mortality rates, and lncRNAs like RHPN1-AS1 have been linked to its progression.
- This study found that RHPN1-AS1 is increased in HCC tissues and that higher levels are associated with worse disease features, while miR-7-5p is decreased.
- Experimentally, silencing RHPN1-AS1 reduced HCC cell growth and spread, revealing that it promotes HCC by targeting miR-7-5p and activating the PI3K/AKT/mTOR signaling pathway.