Unstable States and the Biologization of Mental Illness.

We critically examine how biological narratives of mental illness mediate relations between personal experiences and socio-structural conditions of distress in crisis contexts. Using three case studies of contemporary crises in Russia, the Republic of Cameroon, and Bangladesh, we showcase the ways in which biological meanings of mental illness carry political and structural significance as authorities employ "biologization" for political ends. In Russia, biologization is strategically useful to authorities seeking to control a populace, as chronic "conditions" can be "treated" indefinitely.

The right to health for socioeconomically disadvantaged TB patients in South Korea: An AAAQ framework analysis.

Tuberculosis, a disease of poverty, continues to disproportionately affect socioeconomically disadvantaged populations worldwide. This is particularly concerning given the recent resurgence of TB following the COVID-19 pandemic. In South Korea, despite substantial socioeconomic development, TB remains a prominent problem, ranking as the leading infectious killer in the country.

Single-cell RNA-Seq data have prevalent blood contamination but can be rescued by Originator, a computational tool separating single-cell RNA-Seq by genetic and contextual information.

Single-cell RNA sequencing (scRNA-Seq) data from complex human tissues have prevalent blood cell contamination during the sample preparation process. They may also comprise cells of different genetic makeups. These issues demand rigorous preprocessing and filtering prior to the downstream functional analysis, to avoid biased conclusions due to cell types not of interest.

Cosmic ray feedback in galaxies and galaxy clusters: A pedagogical introduction and a topical review of the acceleration, transport, observables, and dynamical impact of cosmic rays.

Understanding the physical mechanisms that control galaxy formation is a fundamental challenge in contemporary astrophysics. Recent advances in the field of astrophysical feedback strongly suggest that cosmic rays (CRs) may be crucially important for our understanding of cosmological galaxy formation and evolution. The appealing features of CRs are their relatively long cooling times and relatively strong dynamical coupling to the gas.

Fast rotating blue stragglers prefer loose clusters.

Blue stragglers are anomalously luminous core hydrogen-burning stars formed through mass-transfer in binary/triple systems and stellar collisions. Their physical and evolutionary properties are largely unknown and unconstrained. Here we analyze 320 high-resolution spectra of blue stragglers collected in eight galactic globular clusters with different structural characteristics and show evidence that the fraction of fast rotating blue stragglers (with rotational velocities larger than 40 km/s) increases for decreasing central density of the host system.

Identifiability and inference of phylogenetic birth-death models.

Recent theoretical work on phylogenetic birth-death models offers differing viewpoints on whether they can be estimated using lineage-through-time data. Louca and Pennell (2020) showed that the class of models with continuously differentiable rate functions is nonidentifiable: any such model is consistent with an infinite collection of alternative models, which are statistically indistinguishable regardless of how much data are collected. Legried and Terhorst (2022) qualified this grave result by showing that identifiability is restored if only piecewise constant rate functions are considered.

Separating and reintegrating latent variables to improve classification of genomic data.

Genomic data sets contain the effects of various unobserved biological variables in addition to the variable of primary interest. These latent variables often affect a large number of features (e.g.

Protocol - Evaluating the Effect of ACA Medicaid Expansion on Mortality During the COVID-19 Pandemic Using County-level Matching.

States are able to choose whether to expand Medicaid as part of the Affordable Care Act (ACA); thus it is of interest to understand the impact of this policy choice. In this protocol, we outline a study on the impact of Medicaid expansion as part of the ACA on mortality during the COVID-19 pandemic in the United States. County-level matching using full, optimal matching with a propensity score model is used to estimate causal effects in this observational study.

Pattern of bone marrow lipid composition measures along the vertebral column: A descriptive study of adolescents with idiopathic scoliosis.

Background: There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism during growth independent of the amount of bone marrow adipose tissue. The goal of this study was to characterize the pattern of lipid composition index measures from the thoracic to lumbar spine (T11-L4) among a sample of adolescents with idiopathic scoliosis (AIS) undergoing routine orthopedic surgical care for scoliosis correction.

Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery.

Background: Lipidomics, a branch of metabolomics, is an attractive technique to characterize bone marrow lipid composition, which may be associated with skeletal acquisition and homeostasis. However, the reliability of lipidomics-derived lipid composition of the bone marrow is unknown, especially for pediatric populations with bone fragility. The purpose of this study was to evaluate the intersite reliability and standard error of measurement (SEM) of vertebral bone marrow lipid composition at the thoracic (T11/T12) and lumbar (L1/L2) spine determined by targeted lipidomics among children with varying degrees of bone fragility undergoing routine orthopedic surgery.

Running out? Rethinking resource depletion.

Since the 1970s, environmentalists have warned that overconsumption, especially of minerals and fossil fuels, will lead to resource depletion. But there are compelling reasons to question the assertion that we are running out. On the one hand, new technologies and discoveries have increased the supply of petroleum and natural gas.

The earliest domestic cat on the Silk Road.

We present the earliest evidence for domestic cat (Felis catus L., 1758) from Kazakhstan, found as a well preserved skeleton with extensive osteological pathologies dating to 775-940 cal CE from the early medieval city of Dzhankent, Kazakhstan. This urban settlement was located on the intersection of the northern Silk Road route which linked the cities of Khorezm in the south to the trading settlements in the Volga region to the north and was known in the tenth century CE as the capital of the nomad Oghuz.

Social relationships and caregiving behavior between recently orphaned chimpanzee siblings.

When their mothers die, chimpanzees often adopt younger vulnerable siblings who survive with their care. This phenomenon has been widely reported, but few studies provide details regarding how sibling relationships change immediately following the deaths of their mothers. A disease outbreak that killed several females at Ngogo in Kibale National Park, Uganda, furnished an opportunity to document how maternal death influenced the social relationships of siblings.

Selection for longer limbs in mice increases bone stiffness and brittleness, but does not alter bending strength.

The ability of a bone to withstand loads depends on its structural and material properties. These tend to differ among species with different modes of locomotion, reflecting their unique loading patterns. The evolution of derived limb morphologies, such as the long limbs associated with jumping, may compromise overall bone strength.

EDGE EXCHANGEABLE MODELS FOR INTERACTION NETWORKS.

Many modern network datasets arise from processes of interactions in a population, such as phone calls, email exchanges, co-authorships, and professional collaborations. In such interaction networks, the edges comprise the fundamental statistical units, making a framework for edge-labeled networks more appropriate for statistical analysis. In this context we initiate the study of and explore its basic statistical properties.

Structure of photodissociation fronts in star-forming regions revealed by observations of high-J CO emission lines with Herschel.

Context: In bright photodissociation regions (PDRs) associated to massive star formation, the presence of dense "clumps" that are immersed in a less dense interclump medium is often proposed to explain the difficulty of models to account for the observed gas emission in high-excitation lines.

Aims: We aim at presenting a comprehensive view of the modeling of the CO rotational ladder in PDRs, including the high-J lines that trace warm molecular gas at PDR interfaces.

Methods: We observed the CO and CO ladders in two prototypical PDRs, the Orion Bar and NGC 7023 NW using the instruments onboard .

Age trajectories of musculoskeletal morbidities in adults with cerebral palsy.

Background: Individuals with cerebral palsy (CP) are at an increased risk for age-related morbidities due to functional impairments, maladapted growth, and altered body composition. While musculoskeletal (MSK) deficits are present in children, little is understood about MSK morbidity throughout the lifespan in those with CP. The purpose of this study was to examine the age-related trajectories of MSK morbidity and multimorbidity throughout adulthood in those with CP.

Complex signatures of natural selection at GYPA.

The human MN blood group antigens are isoforms of glycophorin A (GPA) encoded by the gene, GYPA, and are the most abundant erythrocyte sialoglycoproteins. The distribution of MN antigens has been widely studied in human populations yet the evolutionary and/or demographic factors affecting population variation remain elusive. While the primary function of GPA is yet to be discovered, it serves as the major binding site for the 175-kD erythrocyte-binding antigen (EB-175) of the malarial parasite, Plasmodium falciparum, a major selective pressure in recent human history.

Adolescent male chimpanzees do not form a dominance hierarchy with their peers.

Dominance hierarchies are a prominent feature of the lives of many primate species. These hierarchies have important fitness consequences, as high rank is often positively correlated with reproduction. Although adult male chimpanzees strive for status to gain fitness benefits, the development of dominance relationships is not well understood.

No evidence for contagious yawning in lemurs.

Among some haplorhine primates, including humans, relaxed yawns spread contagiously. Such contagious yawning has been linked to social bonds and empathy in some species. However, no studies have investigated contagious yawning in strepsirhines.

EXPLORING THE ORIGINS OF DEUTERIUM ENRICHMENTS IN SOLAR NEBULAR ORGANICS.

Deuterium-to-hydrogen (D/H) enrichments in molecular species provide clues about their original formation environment. The organic materials in primitive solar system bodies generally have higher D/H ratios and show greater D/H variation when compared to D/H in solar system water. We propose this difference arises at least in part due to (1) the availability of additional chemical fractionation pathways for organics beyond that for water, and (2) the higher volatility of key carbon reservoirs compared to oxygen.

On the degrees of freedom of reduced-rank estimators in multivariate regression.

We study the effective degrees of freedom of a general class of reduced-rank estimators for multivariate regression in the framework of Stein's unbiased risk estimation. A finite-sample exact unbiased estimator is derived that admits a closed-form expression in terms of the thresholded singular values of the least-squares solution and hence is readily computable. The results continue to hold in the high-dimensional setting where both the predictor and the response dimensions may be larger than the sample size.

Modeling the community-level effects of male incarceration on the sexual partnerships of men and women.

Men who have been incarcerated experience substantial changes in their sexual behavior after release from jail and prison, and high rates of incarceration may change sexual relationship patterns at a community level. Few studies, however, address how rates of incarceration affect community patterns of sexual behavior, and the implications of those patterns for HIV and STD risk. We describe a "proof of principle" computational model that tests whether rates of male incarceration could, in part, explain observed population-level differences in patterns of sexual behavior between communities with high rates of incarceration and those without.