Amplifying Research: The Potential for Podcasts to Boost Journal Article Exposure.

Background Podcasts have become an increasingly popular method of communicating information in medicine, including in radiology. However, the effect of podcasts on the reach of journal articles remains unclear. Purpose To evaluate the influence of podcasts on the performance metrics, including downloads, citations, and Altmetric Attention Score (AAS), of articles.

Paralytic ileus in the neonate as a rare complication of maternal methadone treatment-a case report.

Narcotic bowel syndrome is defined as worsening abdominal bloating and cramping with chronic opiate use, leading to paralytic ileus. This syndrome is common yet underreported in adults. However, there is no current evidence of such conditions in the newborn after exposure to high doses of opiates.

The physiopathology of osteoarthritis: Paleopathological implications of non-articular lesions from a modern surgical sample.

Objectives: This research focused on osteoarthritis (OA) lesions on modern patients to 1) identify consistently observed lesions not included within current paleopathological measures of OA, 2) assess the correspondence of bone and cartilage lesions with clinical OA diagnostic criteria, and 3) discuss the correspondence of bone lesions with sources of pain reported in clinical literature.

Materials: Tibial plateaus from 62 patients undergoing total knee replacement surgery due to OA were examined.

Methods: Plateaus were scored for several non-standard OA criteria, including non-articular and X-ray visible lesions and pre-maceration cartilage lesions, as well as articular surface criteria standard in paleopathology.

Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer.

Overexpression of insulin growth factor receptor type 1 (IGF-1R) is observed in many cancers. Antibody drug conjugates (ADCs) with PEGylated maytansine (PEG-DM1) show promise in vitro. We developed PEG-DM1 ADCs with low and high drug to antibody ratios (DAR) using an anti-IGF-1R antibody cixutumumab (IMC-A12).

Importance of prompt diagnosis in pediatric epilepsy outcomes.

Purpose: Recognition of childhood epilepsy has improved worldwide. Children with epilepsy require immediate healthcare evaluation and monitoring. The interval between the onset of the first seizures and pediatric neurology assessment may influence the epilepsy outcome at follow-up assessments.

Generative adversarial network in medical imaging: A review.

Generative adversarial networks have gained a lot of attention in the computer vision community due to their capability of data generation without explicitly modelling the probability density function. The adversarial loss brought by the discriminator provides a clever way of incorporating unlabeled samples into training and imposing higher order consistency. This has proven to be useful in many cases, such as domain adaptation, data augmentation, and image-to-image translation.

Tuberculosis in Canada and the United States: a review of trends from 1953 to 2015.

Objectives: To explore tuberculosis (TB) incidence in Canada and the United States from 1953 to 2015. In the most recent decade, the US incidence was lower than that of Canada. Since both countries are high income and have low TB incidence with similar TB surveillance programs, we hypothesized that rates should be similar.

Mental Health and Affect Regulation Impairment in Fetal Alcohol Spectrum Disorder (FASD): Results from the Canadian National FASD Database.

Aims: Individuals with fetal alcohol spectrum disorder (FASD) frequently have challenges with regulating emotional arousal, or affect regulation (AR), and experience high rates of mental health disorders. This study examined children and adults with FASD to investigate the relationship between AR impairment and several mental health problems and diagnoses.

Methods: Data from the Canadian national FASD database was used for analysis.

The in vitro antibacterial activity of the anthelmintic drug oxyclozanide against common small animal bacterial pathogens.

Background: Repurposing existing drugs is one approach to address the growing concerns of multi-drug resistant bacterial pathogens in veterinary medicine. Oxyclozanide is in the anthelmintic drug class salicylanilide, which has been used primarily as a treatment and preventative for Fasciola hepatica in ruminants. The antimicrobial activity of oxyclozanide has been studied in human medicine; its activity against common small animal bacterial pathogens such as Staphylococcus pseudintermedius has yet to be determined.

Iron quantification in Parkinson's disease using an age-based threshold on susceptibility maps: The advantage of local versus entire structure iron content measurements.

Background: Elevated brain iron has been observed in Idiopathic Parkinson's disease (IPD) within the deep gray matter. Using quantitative susceptibility mapping (QSM) and a thresholded high-iron region, we quantified iron content in the midbrain of patients with Parkinson's disease as a function of age.

Methods: We used MRI to scan 24 IPD patients at 3-Tesla.

Ketamine-based anesthesia improves electroconvulsive therapy outcomes: a randomized-controlled study.

Background: Major depressive disorder (MDD) is a common and debilitating condition that can be challenging to treat. Electroconvulsive therapy (ECT) is currently the therapeutic gold standard for treatment-resistant MDD. We tested our hypothesis that ketamine-based anesthesia for ECT results in superior improvement in treatment-resistant MDD outcomes compared with propofol-based anesthesia.

Enrolling children with acute lymphoblastic leukaemia on a clinical trial improves event-free survival: a population-based study.

Background: The objectives of this study were to describe the impact of trial enrollment at diagnosis on event-free and overall survival in paediatric acute lymphoblastic leukaemic (ALL) using a population-based approach.

Methods: We conducted a retrospective cohort study that included children newly diagnosed with ALL between 1 and 14 years of age. The data source was the Cancer in Young People in Canada (CYP-C) national paediatric cancer population-based database.

Thyroid Nodule Classification in Ultrasound Images by Fine-Tuning Deep Convolutional Neural Network.

With many thyroid nodules being incidentally detected, it is important to identify as many malignant nodules as possible while excluding those that are highly likely to be benign from fine needle aspiration (FNA) biopsies or surgeries. This paper presents a computer-aided diagnosis (CAD) system for classifying thyroid nodules in ultrasound images. We use deep learning approach to extract features from thyroid ultrasound images.

Anesthesiology Resident Wellness Program at the University of Saskatchewan: concept and development.

Purpose: We describe the need for an anesthesiology resident wellness program (ARWP) and the challenges associated with its development and implementation. We also present the results of a preliminary program evaluation.

Methods: We conducted a needs assessment of Canadian anesthesiology residency programs for a formal ARWP.

Anesthesiology Resident Wellness Program at the University of Saskatchewan: curriculum content and delivery.

Resident and physician health are increasingly recognized by the Royal College of Physicians and Surgeons of Canada and its CanMEDS framework as integral to residency training in Canada. Resident stress, burnout, and depression also have implications for patient care. Although curricula have been advocated to promote resident wellness and resilience, no such published curricula exist to guide programs in addressing these needs.

A Qualitative Evaluation of Program Budgeting and Marginal Analysis in a Canadian Pediatric Tertiary Care Institution.

Background: Hospitals in Canada are being asked by governments to improve efficiency and do more with fewer resources. Healthcare decision makers are thus driven to find better ways to manage budgets and deliver on their mission. Formal processes of priority setting and resource allocation (PSRA) are one means to this end.

Incidence of CT Contrast Agent-Induced Nephropathy: Toward a More Accurate Estimation.

Objective: Acute kidney injury is common among hospitalized patients and likely leads to inflated reports of the incidence of CT contrast agent-induced nephropathy as a cause of acute kidney injury. For a more accurate estimation, we compared the incidence of acute kidney injury immediately after contrast agent administration and a few days afterward in the same population. We also controlled for a creatinine level increase starting before and continuing after CT, which may be incorrectly associated with the scan itself.

Bacterial contamination of ultrasound probes at a tertiary referral university medical center.

Objective: The purpose of this study was to assess the adequacy of our institution's ultrasound probe-disinfecting protocols, determine compliance with the guidelines, and then implement changes if needed.

Materials And Methods: We first assessed the prevalence of bacterial contamination (and thus the potential for bacterial transmission) by swabbing all ultrasound probes (n = 31) in the radiology department and culturing the samples. Next, in conditions simulating the typical work environment, we determined the efficacy of our probe-disinfecting protocols by seeding probes with 10(4)-10(9) CFU/mL of methicillin-resistant Staphylococcus aureus (MRSA), disinfecting the seeded probes with 0.

Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension.

Background: Angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs) are widely prescribed for primary hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg). However, while ACE inhibitors have been shown to reduce mortality and morbidity in placebo-controlled trials, ARBs have not. Therefore, a comparison of the efficacies of these two drug classes in primary hypertension for preventing total mortality and cardiovascular events is important.

Stimulating thoracic epidural placement via a lumbar approach causes significant spinal cord damage in a porcine model.

Background: Continuous thoracic epidural analgesia is a valuable and common technique for analgesia but involves risk to the spinal cord. There is significant pediatric experience safely placing thoracic epidurals via a caudal approach. The use of a stimulating catheter offers the advantage of real-time confirmation of appropriate catheter placement.

Tracheal palpation to assess endotracheal tube depth: an exploratory study.

Purpose: Correct placement of the endotracheal tube (ETT) occurs when the distal tip is in mid-trachea. This study compares two techniques used to place the ETT at the correct depth during intubation: tracheal palpation vs placement at a fixed depth at the patient's teeth.

Methods: With approval of the Research Ethics Board, we recruited American Society of Anesthesiologists physical status I-II patients scheduled for elective surgery with tracheal intubation.