12 results match your criteria: "10255 Science Center Drive[Affiliation]"
Int J Syst Evol Microbiol
June 2023
Native Microbials, 10255 Science Center Drive Suite C2, San Diego, CA 92121, USA.
Int J Syst Evol Microbiol
March 2023
Native Microbials, 10255 Science Center Drive Suite C2, San Diego, CA 92121, USA.
This study presents MP1D12 (=NRRL B-67553=NCTC 14480), an isolate from the ruminal content of an Angus steer fed a high grain diet. Phenotypic and genotypic traits of the isolate were explored. MP1D12 was found to be a strictly anaerobic, catalase-negative, oxidase-negative, coccoid bacterium that frequently grows in chains.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
August 2021
Native Microbials, 10255 Science Center Drive, San Diego, CA 92121, USA.
This study describes JE7A12 (=ATCC TSD-225=NCTC 14479), an isolate from the ruminal content of a dairy cow. Phenotypic and genotypic traits of the isolate were explored. JE7A12 was found to be a strictly anaerobic, catalase-negative, oxidase-negative, coccoid bacterium that grows in chains.
View Article and Find Full Text PDFSci Adv
June 2016
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607-7061, USA.
Time-gated Förster resonance energy transfer (FRET) using the unique material combination of long-lifetime terbium complexes (Tb) and semiconductor quantum dots (QDs) provides many advantages for highly sensitive and multiplexed biosensing. Although time-gated detection can efficiently suppress sample autofluorescence and background fluorescence from directly excited FRET acceptors, Tb-to-QD FRET has rarely been exploited for biomolecular imaging. We demonstrate Tb-to-QD time-gated FRET nanoassemblies that can be applied for intra- and extracellular imaging.
View Article and Find Full Text PDFImmunity
August 2014
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Coreceptor CD4 and CD8αβ double-negative (DN) TCRαβ(+) intraepithelial T cells, although numerous, have been greatly overlooked and their contribution to the immune response is not known. Here we used T cell receptor (TCR) sequencing of single cells combined with retrogenic expression of TCRs to study the fate and the major histocompatibility complex (MHC) restriction of DN TCRαβ(+) intraepithelial T cells. The data show that commitment of thymic precursors to the DN TCRαβ(+) lineage is imprinted by their TCR specificity.
View Article and Find Full Text PDFSensors (Basel)
July 2012
eBioscience, Inc., 10255 Science Center Drive, San Diego, CA 92121, USA.
Advances in spectral deconvolution technologies are rapidly enabling researchers to replace or enhance traditional epifluorescence microscopes with instruments capable of detecting numerous markers simultaneously in a multiplexed fashion. While significantly expediting sample throughput and elucidating sample information, this technology is limited by the spectral width of common fluorescence reporters. Semiconductor nanocrystals (NC's) are very bright, narrow band fluorescence emitters with great potential for multiplexed fluorescence detection, however the availability of NC's with facile attachment chemistries to targeting molecules has been a severe limitation to the advancement of NC technology in applications such as immunocytochemistry and immunohistochemistry.
View Article and Find Full Text PDFACS Nano
July 2011
eBioscience, Inc., 10255 Science Center Drive, San Diego, California 92121, USA.
Bioorg Med Chem Lett
May 2006
Ligand Pharmaceuticals Inc., 10255 Science Center Drive, San Diego, CA 92121, USA.
A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.
View Article and Find Full Text PDFChem Biol
May 1999
Department of Medicinal Chemistry, Ligand Pharmaceuticals, Inc. 10255 Science Center Drive, San Diego, CA 92121, USA.
Background: The secosteroid 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) acts through the vitamin D receptor (VDR) to elicit many activities that make it a promising drug candidate for the treatment of a number of diseases, including cancer and psoriasis. Clinical use of 1,25(OH)2D3 has been limited by hypercalcemia elicited by pharmacologically effective doses. We hypothesized that structurally distinct, nonsecosteroidal mimics of 1,25(OH)2D3 might have different activity profiles from vitamin D analogs, and set out to discover such compounds by screening small-molecule libraries.
View Article and Find Full Text PDFJ Med Chem
February 1999
Departments of Medicinal Chemistry, Retinoid Research, and New Leads Discovery, Ligand Pharmaceuticals, Incorporated, 10255 Science Center Drive, San Diego, California 92121, USA.
A novel series of oxime ligands has been synthesized that displays potent, specific activation of the retinoid X receptors (RXRs). The oximes of 3-substituted (tetramethyltetrahydronaphthyl)carbonylbenzoic acids are readily available by condensation with hydroxyl- or methoxylamine; alkylation of the hydroxyl oxime provides a variety of analogues. Oximes and variously substituted oxime derivatives demonstrate high binding affinity for the RXRs and specific RXR activation and, hence, are called rexinoids.
View Article and Find Full Text PDFNucleic Acids Res
June 1998
Ligand Pharmaceuticals Inc., 10255 Science Center Drive, San Diego, CA 92121, USA.
Hepatocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor in the regulation of energy metabolism. In order to gain greater understanding of the binding and activation requirements of HNF-4, we performed genetic analysis of the apoCIII promoter, a promoter that has previously been shown to be highly sensitive to HNF-4-induced transcription. We identified two elements within the apoCIII promoter that bind HNF-4, either of which are sufficient to confer promoter induction in response to HNF-4.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
May 1997
Departments of Orphan Nuclear Receptor and Retinoid Research, Ligand Pharmaceuticals, 10255 Science Center Drive, San Diego, CA 92121, USA.
Steroidogenic factor 1 (SF-1), an orphan member of the intracellular receptor superfamily, plays an essential role in the development and function of multiple endocrine organs. It is expressed in all steroidogenic tissues where it regulates the P450 steroidogenic genes to generate physiologically active steroids. Although many of the functions of SF-1 in vivo have been defined, an unresolved question is whether a ligand modulates its transcriptional activity.
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