Increased numbers of nonattached osteoclasts after long-term zoledronic acid therapy in mice.

Osteoclasts are key players in the maintenance of bone, which is an endocrine target and organ. Bisphosphonates, used for the management of metastatic bone diseases and osteoporosis, suppress osteoclasts. However, the impact of continuously suppressed osteoclasts is unknown.

Guided tissue regeneration: a decision-making model.

Background: Guided tissue regeneration (GTR) has the potential to promote periodontal regeneration, which is one of the goals of periodontal surgery. While many successful reports of periodontal regeneration using barrier membranes exist in the literature, considerable heterogeneity of GTR outcomes is more typical of current reports. The reasons for this variability are numerous, but could be attributed to differences in surgical skills and case selection.

Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry.

Cilia at the node generate a leftward fluid flow that breaks left-right symmetry. However, the molecular mechanisms that regulate ciliogenesis at the node are largely unknown. Here, we show that the epiblast-specific deletion of the gene encoding the BMP type 1 receptor (Acvr1) compromised development of nodal cilia, which results in defects in leftward fluid flow and, thus, abnormalities in left-right patterning.

Mentoring of dental and dental hygiene faculty: a case study.

Given the predicted shortages of dental faculty in the United States, it is important to retain faculty members. Mentoring could play a crucial role in this context. The objectives of this case study were to explore how a six-year mentoring program in the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry changed faculty members' perceptions of support from colleagues and their mentoring expectations.

Patients with special needs: dental students' educational experiences, attitudes, and behavior.

Accreditation standards require U.S. dental schools to prepare their graduates for the diagnosis of treatment needs of patients with special health care needs (SHCN).

The current status of cone beam computed tomography imaging in orthodontics.

Cone beam CT (CBCT) has become an increasingly important source of three dimensional (3D) volumetric data in clinical orthodontics since its introduction into dentistry in 1998. The purpose of this manuscript is to highlight the current understanding of, and evidence for, the clinical use of CBCT in orthodontics, and to review the findings to answer clinically relevant questions. Currently available information from studies using CBCT can be organized into five broad categories: 1, the assessment of CBCT technology; 2, its use in craniofacial morphometric analyses; 3, incidental and missed findings; 4, analysis of treatment outcomes; and 5, efficacy of CBCT in diagnosis and treatment planning.

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche.

Objective: Previously, we reported that annexin-2 (anxa2) plays an important role in hematopoietic stem cell (HSC) localization to the endosteal/osteoblastic marrow niche. This study explored the role that annexin-2 plays in presenting stromal cell-derived factor-1 (or CXCL12) to HSCs.

Materials And Methods: Competitive long-term bone marrow transplant assays were used to determine if HSC engraftment is altered in annexin-2-deficient animals.

Salivary glucose levels are unable to predict oral candidiasis or monitor diabetes.

Article Title And Bibliographic Information: Salivary glucose levels and oral candidal carriage in type II diabetics. Sashikumar R, Kannan R. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109(5):706-11.

Dental education about patients with special needs: a survey of U.S. and Canadian dental schools.

The objectives of this study were to explore how U.S. and Canadian dental schools educate students about special needs patients and which challenges and intentions for curricular changes they perceive.

Cross-sectional analysis of the mandibular lingual concavity using cone beam computed tomography.

Objectives: To study the prevalence and the degree of lingual concavity in the edentulous first molar region from cone beam computed tomography (CBCT) scans of the mandibles.

Material And Methods: Qualified cross-sectional images in mandibular first molar edentulous region taken from CBCT were selected. The mandible morphology 2 mm above the inferior alveolar canal (IAC) was classified into the convex (C), parallel (P) and undercut (U) type, based on the presence of lingual concavity and the shape of alveolar ridge.

Mechanisms of growth cone repulsion.

Research conducted in the last century suggested that chemoattractants guide cells or their processes to appropriate locations during development. Today, we know that many of the molecules involved in cellular guidance can act as chemorepellents that prevent migration into inappropriate territories. Here, we review some of the early seminal experiments and our current understanding of the underlying molecular mechanisms.

Creation of a scholars program in dental leadership (SPDL) for dental and dental hygiene students.

There is a great need for leaders in the dental profession. As technological advances make our world smaller and our lives faster and more complex, we as a profession face challenges and opportunities that are evolving. Many of the changes in the scope and mode of practice will require new and different approaches.

Sandwich bone augmentation for predictable horizontal bone augmentation.

There is much evidence in the literature to support the success and predictability of guided bone regeneration. Multiple techniques have been introduced using various types of membranes and bone grafting materials. The clinician is now faced with having to select the most predictable guided bone regeneration technique put forth within this extensive literature.

Effectiveness of gloves and infection control in dentistry: student and provider perspectives.

The objectives of this study were to explore dental and dental hygiene students', graduate students', and dental professionals' preferences for certain types of gloves and the reasons for these preferences (Aim 1), as well as determining their knowledge, attitudes, and behavior concerning the use of dental gloves as a means of barrier protection (Aim 2). Data were collected from 198 dental and forty-six dental hygiene students, thirty-five graduate students, and seventy-nine dental professionals (twenty-eight dentists and fifty-one dental hygienists in private practice). The subjects responded to a self-administered anonymous survey.

Orthodontists' and orthodontic residents' education in treating underserved patients: effects on professional attitudes and behavior.

The U.S. surgeon general's report on oral health in 2000 stressed the importance of providing dental care for underserved patient groups.

Ability of dental students to deliver oxygen in a medical emergency.

This study was conducted to evaluate the ability of dental students to administer emergency oxygen to a patient during a simulated emergency. Forty third-year (D3) and fourth-year (D4) dental students were recruited and asked to demonstrate their ability in managing a simulated angina attack. Students were tested on their knowledge related to emergency medical protocols, the time taken to obtain oxygen, and operation of the oxygen equipment.

High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc.

Objectives: Diffusion tensor imaging (DTI) is an MRI modality for characterizing the property, microstructural organization and function in tissues such as the brain and spinal cord. Prior to this investigation, DTI had not been adapted for studies of the temporomandibular joint (TMJ) disc. Objectives were to test the feasibility of DTI to evaluate the porcine TMJ disc and to use DTI to observe differences in magnitude of anisotropy of water diffusion between TMJ disc regions.

Dental hygiene education about patients with special needs: a survey of U.S. programs.

The objective of this study was to explore how dental hygiene programs in the United States educate their students about treating patients with special needs. Data were collected from 102 U.S.

MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells.

Previous studies have demonstrated an inverse relationship between constitutive or stimulated collagenase expression and osteoblastic phenotype of osteogenic cells. However, the direct effects of cell-secreted collagenases on osteoblastic differentiation, and the precise contributions of the key collagenolytic MMPs, MMP-1 and -13 to the modulation of specific osteoblastic markers have not been elucidated. Early passage osteogenic human periodontal ligament (PDL) cells were exposed to exogenous collagenase-1 in the presence and absence of dexamethasone.

ABC sinus augmentation classification.

Edentulism in the posterior maxilla can present with compounding variables that make it a difficult region to restore with implants. Pneumatization of the sinus floor is typically accounted for during surgical treatment planning, but other factors such as horizontal ridge deficiency and vertical defects may be overlooked. This report reviews the different classifications used to treat the posterior maxilla and introduces a new system that incorporates all factors critical for implant success.

Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone.

Therapeutic radiation is commonly used in the treatment of squamous cell carcinoma of the oral cavity and pharynx. Despite the proven efficacy of this form of anticancer therapy, high-dose radiation treatment is invariably associated with numerous unwanted side effects. This is particularly true for bone, in which radiation treatment often leads to osteoradionecrosis.

CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12.

Stromal derived factor-1 (SDF-1 or CXCL12) expressed by osteoblasts and endothelial cells, and its receptors CXCR4 and CXCR7/RDC1 are key molecular determinants in prostate cancer (PCa) metastasis. What drives PCa cells into the extravascular marrow space(s) once they make contact with the blood vessel endothelium, however remains unclear. Here, we evaluated whether degradation of CXCL12 facilitates PCa cell entry into the marrow cavity by locally lowering CXCL12 levels intravascularly.

Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche.

Crosstalk between hematopoietic stem cells (HSCs) and the cells comprising the niche is critical for maintaining stem cell activities. Yet little evidence supports the concept that HSCs regulate development of the niche. Here, the ability of HSCs to directly regulate endosteal development was examined.

Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers.

Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as "redefining" dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long-term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.

Cell surface expression of stem cell antigen-1 (Sca-1) distinguishes osteo-, chondro-, and adipoprogenitors in fetal mouse calvaria.

The flat bones of the skull (calvaria) develop by balanced cell proliferation and differentiation in the calvarial sutures and the bone tips. As the brain grows and the calvaria expand, cells within the sutures must remain undifferentiated to maintain suture patency, but osteoprogenitors also need to be recruited into the osteogenic fronts. The exact identity of calvarial osteoprogenitors is currently not known.