Increased In Vivo Thrombin Generation in Patients with Localized Non-Small Cell Lung Cancer Unfit for Surgery.

Patients with lung cancer face a substantially increased risk of thromboembolic disease. Patients with localized non-small cell lung cancer (NSCLC) who are unfit for surgery due to age or comorbidity have additional thrombotic risk factors. Thus, we aimed to investigate markers of primary and secondary hemostasis, since this could assist in treatment decisions.

Adapting to the Sound of Music - Development of Music Discrimination Skills in Recently Implanted CI Users.

Cochlear implants (CIs) are optimized for speech perception but poor in conveying musical sound features such as pitch, melody, and timbre. Here, we investigated the early development of discrimination of musical sound features after cochlear implantation. Nine recently implanted CI users (CIre) were tested shortly after switch-on (T1) and approximately 3 months later (T2), using a musical multifeature mismatch negativity (MMN) paradigm, presenting four deviant features (intensity, pitch, timbre, and rhythm), and a three-alternative forced-choice behavioral test.

Examining the synergies and tradeoffs of net-zero climate protection with the Sustainable Development Goals.

This article discusses and illuminates the synergies and jeopardies or tradeoffs that exist between the 17 Sustainable Development Goals (SDGs) and net-zero or future climate protection options such as greenhouse gas removal (GGR) technologies and solar radiation management (SRM) deployment approaches, respectively. Through a large-scale expert-interview exercise (N = 125), the study finds firstly that numerous synergies and tradeoffs exist between GGR, SRM, and the SDGs. More specifically, we reveal that GGR deployment could enhance the attainment of 16 of the 17 SDGs, but this comes with possible tradeoffs with 12 of the SDGs.

Occlusion Pressure of the Thoracic Duct in Fontan Patients With Lymphatic Failure: Does Dilatation Challenge Contractility?

Background: The Fontan circulation challenges the lymphatic system. Increasing production of lymphatic fluid and impeding lymphatic return, increased venous pressure may cause lymphatic dilatation and decrease lymphatic contractility. In-vitro studies have reported a lymphatic diameter-tension curve, with increasing passive stretch affecting the intrinsic contractile properties of each thoracic duct segment.

The Sonic Meanings of the Life and Death of My Disabled Brother: Listening as a Method for Qualitative Research.

Long neglected listening is an underdeveloped element in western epistemology in general and in qualitative research in particular. However, recent developments in philosophy, sound art, anthropology, and qualitative research open promising pathways for mastering listening as a method and metaphor of inquiry also in health research, where understanding multiple layers of emotionally challenging experiences is crucial, yet often elusive. Through a sonic analysis of autobiographical data about life, death, and my disabled brother, I will try to demonstrate how paying attention to listening and sounds in research can add evolving layers of meaning to the data gathering and analyzing processes.

Incidence, prevalence and regional distribution of systemic sclerosis and related interstitial lung Disease: A nationwide retrospective cohort study.

Objective: To investigate incidence and prevalence of Systemic Sclerosis (SSc) and association with interstitial lung disease (SSc-ILD) in a nationwide population-based study.

Methods: Patients with an incident diagnosis of SSc in 2000-2016 were identified in the Danish National Patient Registry and categorised based on diagnosis of ILD. Incidence- and prevalence proportions were calculated based on the annual population estimates.

Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation.

Systemic inflammation affects cognitive functions and increases the risk of dementia. This phenomenon is thought to be mediated in part by cytokines that promote neuronal survival, but the continuous exposure to which may lead to neurodegeneration. The effects of systemic inflammation on cerebral blood vessels, and their provision of adequate oxygen to support critical brain parenchymal cell functions, remains unclear.

Impact of diabetes on long-term all-cause re-hospitalization after revascularization with percutaneous coronary intervention.

Purpose: The purpose of the study was to investigate the incidence, cause and probability of re-hospitalization within 30 and 365 days after percutaneous coronary intervention (PCI) in patients with diabetes.

Method: Between January 2010 and September 2014, 2763 patients with diabetes were treated with PCI at two Hospitals in Western Denmark. Reasons for readmission within 30 and 365 days were identified.

Improved pregnancy outcomes in systemic lupus erythematosus: A retrospective study of pregnancies from a single centre in Denmark from 2010-2020 compared with the period 1990-2010.

Objectives: Over the past decades new international guidelines recommend that pregnant Systemic lupus erythematosus (SLE) patients are monitored closely in a multi-professional team throughout pregnancy. The importance of low disease activity before pregnancy and continued treatment during pregnancy has been established. However, there is still a high risk of adverse pregnancy outcome (APO).

Colorectal cancer mortality after randomized implementation of FIT-based screening - a nationwide cohort study.

Objective: Evidence of reduction in colorectal cancer (CRC) mortality following CRC screening based on the faecal immunochemical test (FIT) is insufficient. This study aimed to analyse if CRC mortality was reduced after implementing FIT-based screening.

Setting: The Danish national CRC screening programme.

Is the Femoral-Epiphyseal Acetabular Roof (FEAR) index associated with hip pain in patients with hip dysplasia?

Background: Micro instability of the hip joint has been suggested to cause pain in patients with hip dysplasia. Recently, the Femoral-Epiphyseal Acetabular Roof (FEAR) index has been developed to evaluate hip instability in patients with dysplasia.

Purpose: To investigate associations between the FEAR index and patient-reported outcomes before and six months after periacetabular osteotomy (PAO).

Effectiveness of a bandage to prevent re-dislocation after total hip arthroplasty in patients with a previous hip dislocation. A randomized controlled trial with 12-week follow-up.

Objective: To investigate if using a hip bandage is more effective than standard care in the prevention of total hip arthroplasty re-dislocation in patients with a previous total hip arthroplasty dislocation.

Design: randomized controlled trial.

Setting: Holstebro Regional Hospital and Viborg Regional Hospital.

The Hopkins Symptom Checklist (SCL-90-R): A Patient-Reported Outcome Measure in Parkinson's Disease.

: This is the first study applying Clinimetric Patient-Reported Outcome Measures (CLIPROM) criteria to evaluate the construct validity, sensitivity, and clinical utility of the SCL-90-R in patients with Parkinson's disease (PD). : A Rasch analysis was conducted using a sample of 488 PD outpatients. Testing for dimensionality revealed that less than 5% of -tests were significant, indicating that the SCL-90-R subscales entailed the property of construct validity.

Does group-based cognitive therapy improve functional ability, pain, catastrophic thoughts and quality of life in patients with persistent low back pain and psychological risk factors? A randomised controlled trial in a secondary care setting.

Objective: To investigate the effects of a group-based cognitive behavioural intervention for patients with persistent low back pain (LBP) and psychological risk factors referred to secondary care.

Design: A randomised controlled trial.

Setting: Silkeborg Regional Hospital, Denmark.

Intention and Monitoring Influence the Content of Memory Reports.

Objectives: While voluntary memories are intended and expected, involuntary memories are retrieved with no intention and are usually unexpected (when one is not waiting for a memory). The present study investigates the effects of retrieval intentionality () and monitoring processes () on the characteristics of autobiographical memories.

Methods: To this end, by applying mixed-method analysis of memory descriptions (i.

The contribution of professions to the governance of integrated care: Towards a conceptual framework based on case studies from Denmark.

Objective: Good governance of integrated care is key to better health care, but we know little about how professions can help make this happen. Our aim is to introduce a conceptual framework to analyse how professions contribute to the governance of integrated care, and to apply the framework to a secondary analysis of selected case studies from Denmark.

Methods: We developed a framework, which identified the , and of the contribution professions make to the governance of integrated care.

Diagnostic performance of MRI and endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy: a systematic review of the literature.

Background: The diagnostic performance of magnetic resonance imaging (MRI) modalities and/or endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy (nCRT) is unclear.

Purpose: To summarize existing evidence on the diagnostic performance of diffusion-weighted MRI, perfusion-weighted MRI, T2-weighted MR tumor regression grade, and/or endoscopy for assessing complete tumor response after nCRT.

Material And Methods: MEDLINE and Embase databases were searched.

"Humanizing intensive care: A scoping review (HumanIC)".

Significant scientific and technological advances in intensive care have been made. However, patients in the intensive care unit may experience discomfort, loss of control, and surreal experiences. This has generated relevant debates about how to humanize the intensive care units and whether humanization is necessary at all.

Latent Classes of Bidirectional Face-to-Face and Cyber Intimate Partner Violence Among Lesbian, Gay, and Bisexual Emerging Adults: The Role of Minority Stressors.

The rates of intimate partner violence have been found to be higher among lesbian, gay, and bisexual (LGB) individuals when compared with heterosexual populations. However, lesser is known about the impact of specific minority stressors experienced by LGB populations on their face-to-face intimate partner violence (IPV) and cyber IPV experiences. Using a three-step latent class approach, the present study investigated (i) the latent classes of self-reported types of face-to-face IPV and cyber IPV perpetration and victimization and (ii) their associations with LGB distal and proximal minority stressors (i.

Comparing Rape Myth Acceptance Among Police Trainees and Medical Students: A Preliminary Danish Validation of the Updated Illinois Rape Myth Acceptance Scale.

Identifying rape myths among criminal justice and medical professionals is central to preventing secondary victimization. We present the first preliminary Danish validation of McMahon and Farmer's updated Illinois Rape Myth Acceptance scale using samples of police and medical trainees. Exploratory and confirmatory factor analyses result in a 14-item, four-factor measure that demonstrates acceptable model fit, satisfactory convergent and discriminant validity, and good internal consistency.

Patients' and Nurses' Experiences of All Single-Room Hospital Accommodation: A Scoping Review.

Aim And Objective: To identify, examine, and map literature on the experiences of single-room hospital accommodation, exploring what is known about how single-room accommodation in hospitals is viewed by patients and nurses.

Background: Worldwide, hospital design is changing to mainly single-room accommodation. However, there is little literature exploring patients' and nurses' experiences of single-room designs.

Ethical dilemmas embedded in performing fieldwork with nurses in the ICU.

Background: Background: In general, qualitative research design often involves merging together various data collection strategies, and researcher's may need to be prepared to spend longer periods in the field to pursue data collection opportunities that were not foreseen. Furthermore, nurse researchers performing qualitative research among patients and their relatives often experience unforeseen ethical dilemmas.

Aim: This paper aimed to explore aspects of ethical dilemmas related to qualitative nursing research among patients and their relatives in the intensive care unit (ICU).

Incorporation of a Poly-ε-Caprolactone Scaffold in a ;Circular Stapled End-To-End Small Intestine Anastomosis Does Not Have Any Adverse Effects Within 30 days: A Study in Piglets.

Background Incorporation of a poly-ε-caprolactone (PCL) scaffold in circular stapled anastomoses has been shown to increase the anastomotic tensile strength on postoperative day (POD) 5 in a pig model. The aim of this study was to investigate the effects of incorporation of a PCL scaffold in a circular stapled end-to-end small intestine anastomosis, with stricture formation and anastomotic histology as primary outcomes in a 30-day observation period. Methods A total of 15 piglets were included.

Social Frailty and Depression Among Older Adults in Ghana: Insights from the WHO SAGE Surveys.

In this study, we examine the association between social frailty and depression among older adults in Ghana over time. We employed longitudinal data analysis to examine the association between social frailty, socioeconomic status and depression using data from the WHO-SAGE survey. Our descriptive and cross-tabulation analyses show that the prevalence of depression and social frailty among older adults decreased considerably in 2014/2015 compared to 2007/2008.