Imaging Features of Radiofrequency Ablation with Heat-Deployed Liposomal Doxorubicin in Hepatic Tumors.

Introduction: The imaging features of unresectable hepatic malignancies in patients who underwent radiofrequency ablation (RFA) in combination with lyso-thermosensitive liposomal doxorubicin (LTLD) were determined.

Materials And Methods: A phase I dose escalation study combining RFA with LTLD was performed with peri- and post- procedural CT and MRI. Imaging features were analyzed and measured in terms of ablative zone size and surrounding penumbra size.

Prostate biopsy for the interventional radiologist.

Prostate biopsies are usually performed by urologists in the office setting using transrectal ultrasound (US) guidance. The current standard of care involves obtaining 10-14 cores from different anatomic sections. Biopsies are usually not directed into a specific lesion because most prostate cancers are not visible on transrectal US.

High precision semi-automated vertebral height measurement using computed tomography: A phantom study.

The measurement of vertebral heights is necessary for the evaluation of many disorders affecting the spine. High precision is particularly important for longitudinal studies where subtle changes are to be detected. Computed tomography (CT) is the modality of choice for high precision studies.

Precision of syndesmophyte volume measurement for ankylosing spondylitis: a phantom study using high resolution CT.

Ankylosing Spondylitis is a disease characterized by abnormal bone structures (syndesmophytes) growing at intervertebral disk spaces (IDS). The growth of syndesmophytes is typically monitored by visual inspection of radiographs. The limitations inherent to the modality (2D projection of a 3D object) and rater (qualitative human judgment) entail a possibly important loss in sensitivity.

Linear measurement of polyps in CT colonography using level sets on 3D surfaces.

CT colonography has emerged as a minimally invasive alternative to optical colonoscopy for the screening of polyps which are the precursors to colon cancer. Accurate polyp measurement is crucial as the size of a polyp is considered an indication of its potential for malignancy. We present a novel method for the automatic measurement of polyps.

Subvoxel precise skeletons of volumetric data based on fast marching methods.

The accurate calculation of the skeleton of an object is a problem not satisfactorily solved by existing approaches. Most algorithms require a significant amount of user interaction and use a voxel grid to compute discrete and often coarse approximations of this representation of the data. We present a novel, automatic algorithm for computing subvoxel precise skeletons of volumetric data based on subvoxel precise distance fields.

Automated seed placement for colon segmentation in computed tomography colonography.

Rationale And Objective: To present an algorithm to automatically locate seeds for colon segmentation in computed tomography colonography (CTC).

Materials And Methods: The algorithm automatically locates two points (seeds) inside the colon lumen. Because of their high distention and fixed anatomic position, we focus on the cecum and rectum for automatic seed placement.

Angiographic findings in tumoral calcinosis.

Tumor calcinosis is uncommon, typically manifesting as paraarticular, extracapsular soft tissue deposits containing amorphous calcium phosphate and calcium carbonate, with associated hydroxyapatite crystal. CT and MRI are the primary diagnostic radiological tools evaluating these lesions. Primary treatment is early surgical excision with wide margins, as there is a high recurrence rate.

Combined vascular targeted imaging and therapy: a paradigm for personalized treatment.

In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios.