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The role of cytokine mRNA stability in the pathogenesis of autoimmune disease.
Autoimmun Rev
May 2006
Laboratory of Immunology, The National Eye Institute, The National Institutes of Health, Bldg. 10, Rm. 10N112, 10 Center Dr. MSC-1857, Bethesda, MD 20892, USA.
Inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2, tumor-necrosis factor (TNF)-alpha and IL-17 play an important role in the pathogenesis of cell-mediated autoimmune diseases. Cytokine gene expression is tightly regulated at the post-transcriptional level. Cytokine mRNA decay is dependent not only upon cis-elements in the RNA but also upon trans-acting factors such as the RNA binding proteins TTP, HuR, AUF-1, Nucleolin and YB-1.
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