Combination Inhaled Corticosteroid and Short-acting Beta2 Agonist (ICS-SABA) Use for Older Adults With Asthma.

The first combination inhaled corticosteroid and short-acting beta₂ agonist (ICS-SABA) was approved by the Food and Drug Administration (FDA) in 2023 for as-needed treatment or prevention of bronchoconstriction and to reduce the risk of asthma exacerbations in patients 18 years of age and older. The recently approved product contains an ICS-albuterol combination. The 2024 Global Initiative for Asthma (GINA) guidelines recommend as-needed ICS-formoterol as the preferred asthma reliever therapy; however, a GINA alternative recommendation is the use of ICS whenever an as-needed (SABA) is used.

High-Cost Hospitalizations Among Elderly Patients With Cancer.

Purpose: Health care costs are driven by a small proportion of patients, and it is important to identify their characteristics to effectively manage their health care needs. We examined characteristics associated with high-cost inpatient visits of elderly patients with cancer using a national sample.

Methods: We identified 574,367 inpatient visits of individuals age 65 years or older with a cancer diagnosis using the 2014 National Inpatient Sample data, an all-payer sample of inpatient stays in the United States.

Cyclophosphamide Use in Multiple Sclerosis: Levels Detected in Human Milk.

Background: Multiple sclerosis (MS) is a chronic autoimmune inflammatory neurological disease of the central nervous system. It is the most common immune-mediated disorder, affecting >2 million people worldwide. Cyclophosphamide is an alkylating agent commonly used to treat both malignancies and immune-mediated inflammatory nonmalignant processes.

Social Justice and Environmental Justice Is an Easy Blend For Us: You Can't Have One Without the Other-An Interview With CEEJ.

Reverend James Black and his daughter, Joi Black-Tate, are key members of the Center for Environmental and Economic Justice team that served as a community hub for risk dissemination and clinical cohort management during the Gulf Coast Health Alliance: Health risks related to the Macondo Spill effort to characterize risk from the Deepwater Horizon well explosion and crude oil spill. In this interview, Reverend James Black and Ms. Black-Tate discuss how their community in Biloxi, Mississippi, was impacted by the Deepwater Horizon oil spill and connect this catastrophe to their previous experiences with collaborative Environmental Protection Agency projects measuring dioxin in "Back Bay Biloxi" and toxic chemical seepage from the Keesler Air Force Base.

Always on the Edge of the Next Big Storm, the Next Big Spill, Always Vulnerable: An Interview With Bayou Interfaith Shared Community Organizing.

In this interview, Sharon and David Gauthe of Bayou Interfaith Shared Community Organizing (Thibodaux, Louisiana) document their personal experiences with adverse health outcomes that seem connected with oil spill exposures and explain their community organizing model based on interfaith collaboration and informed by the methodology and practice values of social work. They also comment on their conceptual framework of the entire Gulf Coast as a regional environmental justice zone, for which they received a Guardian of the Gulf Award by the U.S.

The Vietnamese Community Members Who Were Part of GC-HARMS Are More Aware of Their Health, Environmental Impacts on Their Health, and How They Can Have Better Health: An Interview With Dustin Nguyen.

In this interview, Mr. Nguyen, Gulf Coast Health Alliance: Health risks related to the Macondo Spill Vietnamese community project hub manager (D'Iberville, Mississippi), describes his community's cultural and financial difficulties finding adequate avenues for healthcare and wellness information before the Deepwater Horizon oil spill. He comments extensively on how the project's clinical component in tandem with the Affordable Care Act promoted transformational changes in access to healthcare for his community and comments on generational shifts within the community in terms of language marginalization, its relationship to the pace of acculturation, and the allure of commercial fishing as a livelihood and a career.

Studying the Human Health and Ecological Impacts of the Deepwater Horizon Oil Spill Disaster (Part 2): Introduction to This Special Issue of New Solutions.

This introduction to the special issue continues an examination of the Gulf Coast Health Alliance: Health Risks Related to the Macondo Spill (GC-HARMS) project that began in New Solutions 28:3. GC-HARMS was part of a National Institute of Environmental Health Sciences-funded Gulf-wide consortium that created regional community-university research partnerships addressing health impacts from the oil spill exposures. Findings from this program enhanced regional preparedness and reinforced existing disaster-response networks.

Three More Voices Papers for This Special Issue of New Solutions-Environmental Justice in the U.S. Gulf Coast Region.

The U.S. states along the northern shores of the Gulf of Mexico have often been described as America's Energy Colony.

Implications of the GC-HARMS Fishermen's Citizen Science Network: Issues Raised, Lessons Learned, and Next Steps for the Network and Citizen Science.

This paper is intended to complement our extended documentation and analysis of the activities of the Gulf Coast Health Alliance: Health Risks related to the Macondo Spill project Community Outreach and Dissemination Core entitled, "Building and maintaining a citizen science network with fishermen and fishing communities after the Deepwater Horizon oil disaster using a Community-Based Participatory Research (CBPR) approach." We discuss nuances of CBPR practice, including trust-building, clarification of stakeholder expectations, balancing timelines and agendas, cultural fluency, and the importance of regional history-political-economic context, regulatory practices, and cultural life-ways-in creating social dynamics that overarch and underpin the entire process. We examine the unique role of knowledge-making hybrid structures like the project's Fishermen's citizen science network and compare/contrast this structure with other models of participatory science or deliberation.

Building and Maintaining a Citizen Science Network With Fishermen and Fishing Communities Post Deepwater Horizon Oil Disaster Using a CBPR Approach.

When the Deepwater Horizon oil rig blew out in 2010, the immediate threats to productive deep water and estuarial fisheries and the region's fishing and energy economies were obvious. Less immediately obvious, but equally unsettling, were risks to human health posed by potential damage to the regional food web. This paper describes grassroots and regional efforts by the Gulf Coast Health Alliance: health risks related to the Macondo Spill Fishermen's Citizen Science Network project.

"Losing Your Land You Feel Like You're Losing Your Identity, Like You're Experiencing Slow Death": An Interview With Chief Thomas Dardar-Houma Nation.

The Houma Nation was a major community hub for the Citizen Science Network seafood sampling conducted as part of the Gulf Coast Health Alliance: Health Risks Related to the Macondo Spill (GC-HARMS) research project. They also managed a clinical cohort to facilitate wellness checkups and collection of biological samples during the project. In this interview, Thomas Dardar, Principal Chief of the Houma Nation, outlines the historical and evolving changes-cultural as well as geophysical-that the Houma Nation must address in an uncharted era of climate-related impacts on weather patterns, sea levels, and sustainable land uses.

Studying the Human Health and Ecological Impacts of the Deep Water Horizon Oil Spill Disaster: Introduction to This Special Issue of New Solutions.

Gulf Coast Health Alliance: Health Risks Related to the Macondo Spill (GC-HARMS) began in 2011 as a component project of the National Institute of Environmental Health Sciences' (NIEHS) Deep Water Horizon (DWH) Research Consortia program. This Gulf-wide consortium created regional community-university research partnerships focused on addressing health impacts resulting from oil spill exposures. Findings from this trans-National Institutes of Health program have helped enhance and refine community disaster preparedness and reinforced local-regional disaster response networks.

"Keep Working for Environmental Justice No Matter How Bleak Things Look. Don't Give Up. Don't Just Go Away": An Interview With Wilma Subra.

MacArthur prize-winning community scientist, Wilma Subra participated in the research of the Gulf Coast Health Alliance: Health Risks Related to the Macondo Spill project. Ms. Subra chronicles the arc of her career as a public health advocate who has informed communities nationwide of active and potential health risks.

"I Remember the Mental Chaos While They Tried To Seal the Well and Clean Up the Oil Spill - How Much Fear and Uncertainty Everyone Felt": An interview with Marylee and Michael Orr, Louisiana Environmental Action Network.

In this interview, Marylee Orr and her son, Michael Orr, of the Louisiana Environmental Action Network (Baton Rouge, LA) recall the massive trauma among fishing families (including those whose boats were used in the clean-up effort) caused by the Deep Water Horizon spill, the state and federal closures of fishing grounds, and the moratorium on oil exploration and production activity during the clean-up efforts. They recount the history of their organization's vision and growth, their role in regional environmental justice efforts, and outline how they developed an approach to rapid response community empowerment based on colearning, respect, consensus, and action-a vision that parallels the work of Paulo Freire and the practice values of community-based participatory research. They discuss the collaborative seafood sampling site map and toxicology primer they built and archived as a key community partner of the Gulf Coast Health Alliance: Health Risks Related to the Macondo Spill Project.

Feasibility Study Using Propensity Score Matching Methods for the Pseudo-Common Person Equating Requirement.

We tested if a propensity score (PS) matching method supports the unidimensionality assumption of the Rasch model which is critical to link similar rehabilitation instruments. We obtained 1,013 respondents from the 2009 Hispanic Established Populations for Epidemiologic Studies of the Elderly Frailty study. We used a unidimensional item pool of 10 SF-36 physical function and nine activities of daily living items.

Influence of Type II Diabetes and High Depressive Symptoms on the Likelihood for Developing Activities of Daily Living (ADL) Disability and Mortality in Older Puerto Ricans.

Objective: To examine the development of activities of daily living (ADL) disability and mortality according to diabetes and high depressive symptoms among Puerto Rican adults aged 60 and older.

Method: Data came from Wave I and Wave II of the Puerto Rican Elderly: Health Conditions Study ( n = 3,419). Logistic regression was used.

Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus.

Background The abnormal biological activity of cytokines plays an important role in the pathophysiology of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Several studies have highlighted the association of vitamin D and certain pro-inflammatory cytokines with disease activity in SLE. However, there are limited data on the association of vitamin D and antiphospholipid antibodies (aPL) with various proinflammatory biomarkers in these patients and their relative impact on clinical outcomes.

The Role of Education in the Relationship Between Age of Migration to the United States and Risk of Cognitive Impairment Among Older Mexican Americans.

Prior research indicates age of migration is associated with cognitive health outcomes among older Mexican Americans; however, factors that explain this relationship are unclear. This study used eight waves from the Hispanic Established Populations for the Epidemiologic Study of the Elderly to examine the role of education in the risk for cognitive impairment (CI) by nativity, age of migration, and gender. Foreign-born women had a higher risk for CI than U.

Functional Changes after Recombinant Human Growth Hormone Replacement in Patients with Chronic Traumatic Brain Injury and Abnormal Growth Hormone Secretion.

We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a moderate-to-severe traumatic brain injury (TBI) with abnormal growth hormone (GH) secretion. Fifteen individuals who sustained a TBI at least 12 months prior to study enrollment were identified as having abnormal GH secretion by glucagon stimulation testing (maximum GH response less than 8 ng/mL). Peak cardiorespiratory capacity, body composition, and muscle force testing were assessed at baseline and one year after rhGH replacement.

Exerting Capacity.

Patient safety has been at the forefront of nursing research since the release of the Institute of Medicine's report estimating the number of preventable adverse events in hospital settings; yet no research to date has incorporated the perspectives of bedside nurses using classical grounded theory (CGT) methodology. This CGT study explored the perceptions of bedside registered nurses regarding patient safety in adult acute care hospitals. Data analysis used three techniques unique to CGT-the constant comparative method, coding, and memoing-to explore the values, realities, and beliefs of bedside nurses about patient safety.

Increased Risk of Death for Patients on the Waitlist for Liver Transplant Residing at Greater Distance From Specialized Liver Transplant Centers in the United States.

Background: We have previously shown that patients listed for orthotopic liver transplantation (OLT) in United Network for Organ Sharing Region 4 (Texas and Oklahoma) have higher waitlist mortality rates when residing more than 30 miles from specialized liver transplant centers (LTC). Considering that findings might only be exclusive for this region with its peculiarities in terms of having the highest land surface extensions, lowest population densities, and largest rural populations. We investigated the entire OLT patient population in the United States to assess if our previous regional findings are nationally validated and if a rural, micropolitan, or metropolitan residence location affects outcome of waitlisted OLT patients in the nation.

Arthritis and Risk of Cognitive and Functional Impairment in Older Mexican Adults.

Objective: This study investigated the risk of cognitive and functional impairment in older Mexicans diagnosed with arthritis. Participants included 2,681 Mexicans, aged ≥60 years, enrolled in the Mexican Health and Aging Study cohort.

Method: Participants were categorized into arthritis and no arthritis exposure groups.