Evaluation of an intervention package developed to reduce pre-registration nursing student attrition rates: A mixed method study.

Background: Higher educational institutions strive to recruit and retain student nurses into pre-registration programmes to support a sustainable nursing workforce. Attrition rates for student nurses are high and escalating, with around one in three nursing students in the United Kingdom failing to complete their degree programmes. Risk factors for student attrition include the attributes students bring to their study environment, as well as their behaviours and academic outputs.

The impact of speaker accent on discourse processing: A frequency investigation.

Previous studies indicate differences in native and foreign speech processing (Lev-Ari, 2018), with mixed evidence for differences between dialectal and foreign accent processing (Adank, Evans, Stuart-Smith, & Scott, 2009; Floccia et al., 2006, 2009; Girard, Floccia, & Goslin, 2008). Two theories have been proposed: The Perceptual Distance Hypothesis suggests that dialectal accent processing is an attenuated version of foreign accent processing (Clarke & Garrett, 2004), while the Different Processes Hypothesis argues that foreign and dialectal accents are processed via distinct mechanisms (Floccia, Butler, Girard, & Goslin, 2009).

Guideline-Directed Medical Therapy After Hospitalization for Acute Heart Failure: Insights From the CONNECT-HF.

Background: Significant gap remains in the implementation of guideline-directed medical therapy (GDMT) in patients with heart failure after a hospitalization. We aimed to evaluate the use and titration of GDMT at discharge and over a 12-month period after hospital discharge and to identify factors associated with GDMT use and titration.

Methods And Results: The CONNECT-HF (Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure) trial evaluated the effect of a hospital and postdischarge quality improvement intervention in participants with heart failure with reduced ejection fraction.

Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers.

Objectives: Vitamin D has a role in the innate immunity against pathogens and is also involved in mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research is limited on the association between VDD and COVID-19 symptom prevalence and duration. The study aimed to determine whether VDD is a risk factor for the presence and extended duration of COVID-19 symptoms.

Environmental tobacco smoke exposure in a multi-city cohort of children with asthma: Analyzing true exposure and the validity of caregiver survey.

Introduction: The avoidance of asthma triggers, like tobacco smoke, facilitates asthma management. Reliance upon caregiver report of their child's environmental tobacco smoke (ETS) exposure may result in information bias and impaired asthma management. This analysis aimed to characterize the chronicity of ETS exposure, assess the validity of caregiver report of ETS exposure, and investigate the relationship between ETS exposure and asthma attack.

Incidence of atrial fibrillation in patients with an insertable cardiac monitor and symptomatic heart failure.

Aims: We aim to evaluate the incidence of atrial fibrillation (AF) in a large real-world cohort of patients implanted with an insertable cardiac monitor (ICM) who had a clinical history of symptomatic heart failure (HF) with reduced or preserved left ventricular ejection fraction (LVEF).

Methods: Patients with an ICM and a history of HF events were identified from the Optum® de-identified Electronic Health Record dataset merged with an ICM device dataset collected during 2007-2021. All ICM-detected AF episodes that were available with ≥30-s of ECG at onset were adjudicated using artificial intelligence (AI model).

Challenges of Faith Community Nursing in a Midwestern Healthcare System.

Faith community nurses are positioned to play a vital role in addressing whole person health in multiple settings. A steady decline of nurses completing faith community nurse (FCN) training in a midwestern healthcare system sparked the system's hospital leadership to re-evaluate the FCN training and outreach program. To inform future education programs, an online needs assessment survey was deployed to FCNs.

Serum levels of total bile acids are associated with an increased risk of HCC in patients with cirrhosis.

Background: Previous studies have reported higher circulating bile acid levels in patients with HCC compared to healthy controls. However, the association between prediagnostic bile acid levels and HCC risk among patients with cirrhosis is unclear.

Methods: We measured total BA (TBA) concentration in serum samples collected from a prospective cohort of patients with cirrhosis who were followed until the development of HCC, death, or last study date.

Preoperative Biofluid Biomarkers for Predicting Postoperative Neurocognitive Disorders in Older Adults: A Systematic Review.

Preoperative biofluid biomarkers reflecting pathophysiological, neuronal injury, and inflammation as well as those for Alzheimer's disease (AD) may be valuable tools for the risk stratification of perioperative neurocognitive disorders (PNDs) in older adults. We summarized current evidence relating these preoperative biomarkers to PND beyond 7 days, in older surgical participants aged ≥60 years. Studies that evaluated the association of preoperative biomarkers with cognitive decline as an outcome, beyond 7 days, were identified through searches of 6 databases and 3 trial registries to 17 January 2024.

The power of lived experience in optimizing US policymakers' engagement with substance use research: A series of rapid-cycle randomized controlled trials.

Background: Research can inform policies on substance use/substance use disorders (SU/SUDs), yet there is limited experimental investigation into strategies for optimizing policymakers' engagement with SU/SUD research. This study tested the use of narratives to boost policymakers' research engagement.

Methods: In five rapid-cycle randomized controlled trials, SU/SUD research fact sheets were emailed to US legislative policymakers.

Safety and efficacy of sertraline in depression among adults undergoing dialysis: a systematic review and meta-analysis.

Background: Depression is prevalent among patients with end-stage renal disease (ESRD) undergoing dialysis, with significant implications for their quality of life and treatment compliance. Traditional treatments for depression, including various therapies and pharmacological interventions, have limitations due to their adverse effects. Sertraline, a selective serotonin re-uptake inhibitor (SSRI), offers a promising alternative, but its efficacy and safety in this population require thorough evaluation.

Safety and immunogenicity of CD40.HIVRI.Env, a dendritic cell-based HIV vaccine, in healthy HIV-uninfected adults: a first-in-human randomized, placebo-controlled, dose-escalation study (ANRS VRI06).

Background: Current HIV prophylactic vaccines evaluate HIV Env as purified proteins. CD40.HIVRI.

Between cultures and traditions: a qualitative investigation of sexual and reproductive health experiences of immigrant adolescents in Canada.

Immigrant adolescents in Canada face challenges accessing accurate sexual and reproductive health (SRH) information and services. Many challenges stem from taboos associated with SRH, cultural and religious restrictions, and social beliefs regarding the unnecessity of SRH education for adolescents. We explored the SRH experiences of immigrant adolescents in the context of their cultural and religious perspectives.

Housing Instability and Outcomes Among Patients With Access-Sensitive Surgical Conditions.

Introduction: Housing instability is a significant contributor to poor health but remains understudied among surgical patients. We evaluated the association between housing instability and rates of unplanned surgical procedures, as well as resultant health and financial outcomes, for patients with access-sensitive conditions.

Methods: Using the Healthcare Cost and Utilization Project National Inpatient Sample, we identified patients who underwent one of four selected procedures for access-sensitive surgical conditions (abdominal aortic aneurysm repair, colectomy, incisional hernia repair, and lower extremity bypass).

Expanded distribution and a new genus for rock-inhabiting sea pens (Cnidaria, Anthozoa, Octocorallia, Pennatuloidea).

Sea pens (Superfamily Pennatuloidea) are a specialized group of octocorals that evolved to live embedded in a soft-sedimented seafloor using their peduncles as anchors. Rock-inhabiting sea pens ("rock pens") were first described in 2011; their peduncle is modified into a suction cup-like structure that allows them to attach onto the surface of hard substrates, an adaptation previously unknown in sea pens. There are currently four species that have been identified as rock pens based on their peduncular morphology: three of these are in the genus Anthoptilum (Anthoptilidae), and one in the genus Calibelemnon (Scleroptilidae).

Review of Nychia marshalli in the Western Palaearctic, with new records and distributional notes (Hemiptera: Heteroptera: Notonectidae).

The backswimmer Nychia marshalli (Scott, 1872) (Hemiptera: Heteroptera: Notonectidae) is reported for the first time from Italy on the island of Sardinia. A new record of N. marshalli from Corsica (the first from the eastern coast) is provided and the distribution of the species in the Western Palearctic region is summarized.

History and historical DNA: Identity of Chelodina intergularis Fry, 1915 and type localities of C. intergularis and C. rugosa Ogilby, 1890.

Based on the phylogenetic placement of a near-complete mitogenome sequence of the holotype of Chelodina intergularis Fry, 1915 generated with hDNA approaches, we present evidence for the synonymy of this nominal species with Chelodina rugosa Ogilby, 1890. The type specimens of both taxa are housed in the Australian Museum, Sydney. Scrutinizing historical records, we conclude that the type locality of both taxa is most likely the vicinity of Somerset, at the northern extremity of Cape York Peninsula, Queensland, Australia.

Clinical and biochemical abnormalities in a feline model of GM2 activator deficiency.

Though it has no catalytic activity toward GM2 ganglioside, the GM2 activator protein (GM2A) is essential for ganglioside hydrolysis by facilitating the action of lysosomal ß-N-acetylhexosaminidase. GM2A deficiency results in death in early childhood due to rapid central nervous system deterioration similar to the related GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease. This manuscript further characterizes a feline model of GM2A deficiency with a focus on clinical and biochemical parameters that may be useful as benchmarks for translational therapeutic research.

Clinical benefits of modifying the evening light environment in an acute psychiatric unit: A single-centre, two-arm, parallel-group, pragmatic effectiveness randomised controlled trial.

Background: The impact of light exposure on mental health is increasingly recognised. Modifying inpatient evening light exposure may be a low-intensity intervention for mental disorders, but few randomised controlled trials (RCTs) exist. We report a large-scale pragmatic effectiveness RCT exploring whether individuals with acute psychiatric illnesses experience additional benefits from admission to an inpatient ward where changes in the evening light exposure are integrated into the therapeutic environment.