2 results match your criteria: "1 National Institute of Biomedical Genomics[Affiliation]"
Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.
Tumour Biol
May 2017
1 National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Article Synopsis
- Epigenetic changes in both HPV and host cellular genomes play a significant role in cervical cancer development by affecting methylation patterns and gene expressions.
- The study found that cervical cancer samples showed higher methylation in specific immunostimulatory regions of the HPV16 genes compared to non-cancerous samples, with HPV16 integration linked to different methylation levels.
- The research indicates that TLR9 expression increases with cervical cancer severity, while DNA methyltransferase genes (DNMT1, DNMT3A, DNMT3B) exhibit varying levels of expression, suggesting that both viral and host cellular methylation are crucial in the pathogenesis of cervical cancer.
Roles for Transcription Factors Sp1, NF-κB, IRF3, and IRF7 in Expression of the Human IFNL4 Gene.
Viral Immunol
October 2016
2 Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India .
The expression of a biologically active human IFNλ4 depends on the presence of a frameshift deletion polymorphism within the first exon of the interferon lambda 4 (IFNL4) gene. In this report, we use the lung carcinoma-derived cell line, A549, which is genetically viable to express a functional IFNλ4, to address transcriptional requirements of the IFNL4 gene. We show that the GC-rich DNA-binding transcription factor (TF) specificity protein 1 (Sp1) is recruited to the IFNL4 promoter and has a role in induction of gene expression upon stimulation with viral RNA mimic poly(I:C).
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