4 results match your criteria: "1 King's College Circle Room 2374[Affiliation]"
Effect of handrail height and age on the timing and speed of reach-to-grasp balance reactions during slope descent.
Appl Ergon
November 2019
Toronto Rehabilitation Institute - University Health Network, 13-000, 550 University Avenue, Toronto, ON, M5G 2A2, Canada; Department of Occupational Science and Occupational Therapy, University of Toronto, 500 University Avenue - Room 160, Toronto, ON, M5G 1V7, Canada; Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W8, Canada.
We investigated the effect of handrail height on the timing and speed of reach-to-grasp balance reactions during slope descent, in fourteen younger and thirteen older adults. Participants walked along an 8° slope mounted to a robotic platform. Platform perturbations evoked reach-to-grasp reactions.
View Article and Find Full Text PDFUse of handrails for balance and stability: Characterizing loading profiles in younger adults.
Appl Ergon
April 2019
iDAPT Centre for Rehabilitation Research, Toronto Rehabilitation Institute - University Health Network, 13-000, 550 University Avenue, Toronto, Ontario, M5G 2A2, Canada; Rehabilitation Sciences Institute, University of Toronto, 500 University Avenue - Room 160, Toronto, Ontario, M5G 1V7, Canada; Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, Ontario, M5S 2W8, Canada; Department of Occupational Science and Occupational Therapy, University of Toronto, 500 University Avenue - Room 160, Toronto, Ontario, M5G 1V7, Canada.
Well-designed handrails significantly enhance balance recovery, by allowing users to apply high forces to the rail and stabilize their center of mass. However, data on user-applied handrail forces during balance recovery are limited. We characterized the peak forces that 50 young adults applied to a handrail during forward and backward falling motions; quantified effects of handrail height (34, 38, 42 inches) and position prior to balance loss (standing beside the rail with or without hand contact, or facing the handrail with two-handed contact); and examined the relationship between handrail forces and individual mass.
View Article and Find Full Text PDFGenomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases.
Ann Clin Transl Neurol
December 2016
Objectives: We assessed the current genetic evidence for the involvement of various cell types and tissue types in the etiology of neurodegenerative diseases, especially in relation to the neuroinflammatory hypothesis of neurodegenerative diseases.
Methods: We obtained large-scale genome-wide association study (GWAS) summary statistics from Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). We used multiple sclerosis (MS), an autoimmune disease of the central nervous system, as a positive control.
Differential effects of cannabis dependence on cortical inhibition in patients with schizophrenia and non-psychiatric controls.
Brain Stimul
September 2017
Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto M5T 1R8, ON, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 250 College Street, Toronto M5T 1R8, ON, Canada; Temerty Centre for Therapeutic Brain Intervention, CAMH, 1001 Queen Street West, Toronto M6J 1H4 ON, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King's College Circle Room 2374, Toronto M5S 1A8, ON, Canada. Electronic address:
Background: Cannabis is the most commonly used illicit substance among patients with schizophrenia. Cannabis exacerbates psychotic symptoms and leads to poor functional outcomes. Dysfunctional cortical inhibition has been implicated in the pathophysiology of schizophrenia; however, the effects of cannabis on this mechanism have been relatively unexamined.
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