4 results match your criteria: "1 Division of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia PA.[Affiliation]"
Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations.
J Am Heart Assoc
August 2024
Department of Epidemiology and Biostatistics School of Public Health, Imperial College London London United Kingdom.
Article Synopsis
- This study investigates the relationship between plasma proteins and stroke risk specifically in South Asian individuals, utilizing genetic data from the UK Biobank and stroke data from the GIGASTROKE consortium.
- Using advanced statistical methods, researchers identified a potential causal link between the glycoprotein GP6 levels and the likelihood of cardioembolic stroke, showing an odds ratio indicating a significant increase in risk.
- Findings suggest that GP6 may not have the same effect on stroke risk in European populations, highlighting the importance of genetic ancestry in biomedical research.
Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis.
J Am Heart Assoc
July 2024
Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom.
Article Synopsis
- - Early age at menarche (AAM) may lead to higher carotid artery intima-media thickness (cIMT), which is a sign of early vascular disease, and understanding this relationship could improve prevention and treatment strategies for cardiovascular issues.
- - The study explored how AAM affects various cardiometabolic risk factors like body mass index (BMI) and blood pressure, using genetic analyses to determine these connections.
- - Results indicated that AAM was negatively linked to cIMT and positively linked to cholesterol levels, with BMI and systolic blood pressure identified as partial mediators in this association.
Background: Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.
Methods And Results: The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study).
Background Heterogeneity in the underlying processes that contribute to heart failure with preserved ejection fraction ( HF p EF ) is increasingly recognized. Diabetes mellitus is a frequent comorbidity in HF p EF , but its impact on left ventricular and arterial structure and function in HF p EF is unknown. Methods and Results We assessed the impact of diabetes mellitus on left ventricular cellular and interstitial hypertrophy (assessed with cardiac magnetic resonance imaging, including T1 mapping pregadolinium and postgadolinium administration), arterial stiffness (assessed with arterial tonometry), and pulsatile arterial hemodynamics (assessed with in-office pressure-flow analyses and 24-hour ambulatory monitoring) among 53 subjects with HF p EF (32 diabetic and 21 nondiabetic subjects).
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