2 results match your criteria: "1 Department of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY.[Affiliation]"
Article Synopsis
- - The study explored how early life stress from maternal separation and early weaning (MSEW) impacts blood pressure in obese male mice, focusing on the role of the renin-angiotensin-aldosterone system.
- - Both control and MSEW mice on a high-fat diet showed similar increases in angiotensinogen levels, but there was no activation of the renin-angiotensin system in their fat or kidneys.
- - Despite a reduction in blood pressure after treating with an angiotensin-converting enzyme inhibitor, MSEW mice still experienced heightened sympathetic tone, indicating that other mechanisms beyond angiotensin II contribute to their elevated blood pressure.
Background Obesity-associated chronic inflammation has been known to contribute to atherosclerosis development, but the underlying mechanisms remain elusive. Recent studies have revealed novel functions of IKK β (inhibitor of NF -κB [nuclear factor κB] kinase β), a key coordinator of inflammation through activation of NF -κB, in atherosclerosis and adipose tissue development. However, it is not clear whether IKK β signaling in adipocytes can also affect atherogenesis.
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