3 results match your criteria: "1 Center for Pulmonary Imaging Research[Affiliation]"

Rationale: Bronchopulmonary dysplasia (BPD) is a serious neonatal pulmonary condition associated with premature birth, but the underlying parenchymal disease and trajectory are poorly characterized. The current National Institute of Child Health and Human Development (NICHD)/NHLBI definition of BPD severity is based on degree of prematurity and extent of oxygen requirement. However, no clear link exists between initial diagnosis and clinical outcomes.

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Rationale: Recent advancements that have been made in magnetic resonance imaging (MRI) improve our ability to assess pulmonary structure and function in patients with cystic fibrosis (CF). A nonionizing imaging modality that can be used as a serial monitoring tool throughout life can positively affect patient care and outcomes.

Objectives: To compare an ultrashort echo-time MRI method with computed tomography (CT) as a biomarker of lung structure abnormalities in young children with early CF lung disease.

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Article Synopsis
  • The study focuses on using MRI to detect and quantify lung structural abnormalities in premature infants, particularly those with bronchopulmonary dysplasia (BPD).
  • MRI findings show that infants with BPD exhibit a significantly larger volume of high-signal lung tissue compared to both full-term infants and premature infants without BPD.
  • The results suggest that MRI could be a valuable tool for diagnosing and characterizing the severity of BPD in neonates, potentially leading to more personalized treatment approaches.
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