C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression.

Objective: Multi-organ failure frequently complicates sepsis, with lungs being the primary target. T helper (Th) cell activation and phenotypic imbalance among them contribute significantly to sepsis-associated lung injury. Additionally, the complement system could regulate the polarized phenotype of T lymphocytes.

RETRACTION: Transcriptional Regulation of βsecretase-1 by 12/15-Lipoxygenase Results in Enhanced Amyloidogenesis and Cognitive Impairments.

J. Chu , J.-M.

Facilitators and barriers of alcohol goals for Latinx men hospitalized with alcohol use disorder seen by an Addiction Consult Team.

Introduction: Latinx individuals are disproportionately affected by alcohol use disorder (AUD). Understanding Latinx individuals' barriers and facilitators to reach AUD-related goals can help implement culturally and linguistically concordant interventions to improve alcohol-related outcomes.

Methods: We conducted semi-structured qualitative interviews with Latinx, Spanish-speaking men with AUD within 20 weeks of hospital discharge who were seen by an addiction consult team during hospitalization in an urban, safety-net hospital in San Francisco.

Modified 'Xingnao Kaiqiao' acupuncture technique shortens the recovery time of comatose patients.

Background: This study was conducted to analyse the therapeutic effect of the modified 'Xingnao Kaiqiao' acupuncture technique in the recovery of comatose patients, as well as the clinical factors that may influence recovery from coma.

Methods: Diagnostic and therapeutic data from 166 patients in a coma due to neurological diseases were retrospectively collected. Eighty-seven comatose patients received conventional treatment, and 79 patients received conventional treatment + the modified 'Xingnao Kaiqiao' acupuncture technique.

The Novel Role of GDI2: A Mini-Review.

GDP Dissociation Inhibitor 2 (GDI2) plays a crucial role in maintaining cellular homeostasis by regulating Rab GTPases involved in vesicular transport. This review highlights the importance of GDI2 in various biological processes, particularly embryonic development, apoptosis regulation, cancer, and immune responses. GDI2's essential function in embryonic development is evidenced by the embryonic lethality observed in GDI2 knockout mice.

Investigation of boiler energy consumption in the gas refinery units using RSM ANN and Aspen HYSYS.

In order to lower total energy consumption, this study focuses on optimizing energy use in refinery boilers. Using Aspen HYSYS simulations and modeling approaches like Artificial Neural Networks (ANNs) and Response Surface Methodology (RSM), data from 579 days of boiler operation was gathered and examined. Radial Basis Function (RBF) and Multi-Layer Perceptron (MLP) techniques were used in the ANN modeling.

Prevalence of food allergy and its association with atopic dermatitis in Iran: Results from the PERSIAN birth cohort.

Background: The incidence of food allergy (FA) has been increasing worldwide, causing growing concern on a global scale.

Objective: This birth cohort study analyzes the incidence of reported FA and other atopic comorbidities in children from birth to age 2 years who were living in 4 urban and semiurban areas in Iran.

Methods: Children were followed from birth until age 24 months, with follow-up questionnaires administered through parent or guardian interviews conducted when the children were aged 2, 4, 6, 12, and 24 months.

The impact of mutations on the clinical outcome and immune response following immunotherapy for pancreatic cancer.

Background: Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second leading cause of cancer-related death by 2030. This is driven by a high case-fatality rate with most patients even with radiologically localized PDAC at diagnosis ultimately relapsing with metastatic disease. mutations present in 90% to 95% of PDAC drive these poor statistics through its role in driving cellular growth, inhibition of apoptosis, and immunosuppression.

Iris: A Next Generation Digital Pathology Rendering Engine.

Digital pathology is a tool of rapidly evolving importance within the discipline of pathology. Whole slide imaging promises numerous advantages; however, adoption is limited by challenges in ease of use and speed of high-quality image rendering relative to the simplicity and visual quality of glass slides. Herein, we introduce Iris, a new high-performance digital pathology rendering system.

Prevalence of immunological aberrations and 22q11.2 deletion in children with conotruncal anomalies: A cross-sectional study.

Introduction: 22q11.2 deletion is associated with conotruncal anomalies and immunological aberrations. Given the common embryonic origin of conotruncus and thymus, conotruncal anomalies may be associated with immunological aberrations irrespective of 22q11.

Early and midterm results of Cook Formula stent in children with right heart disease: A single-center experience.

Background: Branch pulmonary artery (PA) stenosis must be addressed early to prevent right ventricular scarring and establish lung blood flow. Balloon-mounted stents are more useful in managing right ventricular outflow tract (RVOT) obstruction and PA stenosis.

Materials And Methods: We studied the clinical and angiographic data of children with congenital heart disease who underwent stenting for RVOT obstruction and branch PA stenosis using the Formula stent (Cook Medical, Limerick, Ireland) between 2018 and 2024 in a tertiary pediatric cardiac center in southern India.

The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis.

Background: Knee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.

Objective: Describe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.

Design: Observational prospective study.

Moving Beyond the Device: Key Lessons in Creating a Positive Patient Experience for a Remote Foot Health Program.

The burden of diabetic foot ulcers is largely underappreciated, even by the healthcare community. Living with advanced, complex chronic diseases can be challenging for the patient and often requires additional time and resource utilization by the provider. The use of novel technology within medicine should be focused on fostering excellent experiences, thereby promoting satisfaction and ultimately, quality care.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

A comparative analysis of dengue, chikungunya, and Zika manifestations in a pediatric cohort over 18 years.

Background: Dengue, chikungunya, and Zika are mosquito-borne diseases of major human concern. Differential diagnosis is complicated in children and adolescents by their overlapping clinical features (signs, symptoms, and complete blood count results). Few studies have directly compared the three diseases.

De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa.

The U4 small nuclear RNA (snRNA) forms a duplex with the U6 snRNA and, together with U5 and ~30 proteins, is part of the U4/U6.U5 tri-snRNP complex, located at the core of the major spliceosome. Recently, recurrent variants in the U4 RNA, transcribed from the gene, and in at least two other genes were discovered to cause neurodevelopmental disorder.

Longitudinal Measures of Cardiovascular Risk Factors Are Associated with Subfertility in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Introduction: Previous reports have noted associations between subfertility in women and increased risk of cardiovascular disease (CVD) events in later life. However, reports conflict regarding the associations between subfertility and CVD risk factors. Using data from a population-based cohort of Black and White women, we examined the association between longitudinal assessments of CVD risk factors and subfertility.

Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis.

Importance: Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographical regions is necessary for informed public health recommendations and healthcare delivery.

Objective: The primary objective of this systematic review is to evaluate the global prevalence of long COVID and its subtypes and symptoms in individuals with confirmed COVID-19 diagnosis, while the secondary objective is to assess risk factors for long COVID in the same population.

Data Sources: Studies on long COVID published from July 5, 2021, to May 29, 2024, searched from PubMed, Embase, and Web of Science were used for this systematic review.

Preparation and Characterization of the MMT@FeO@Ag Nanocomposite for Catalytic Degradation of Methyl Yellow: Reaction Parameters and Mechanism Based on the Artificial Neuron Network.

The montmorillonite@iron oxide@silver (MMT@FeO@Ag) nanocomposite, which is recyclable and exhibits high catalytic activity, was evaluated for the degradation of methyl yellow (MY), a carcinogenic azo dye. For this purpose, MMT@FeO was first synthesized via the coprecipitation method and then Ag was doped to MMT@FeO via the chemical reduction method. MMT, MMT@FeO, and MMT@FeO@Ag were characterized by various techniques including scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometer, and thermal gravimetric analysis.

Predicting Water Saturation in a Greek Oilfield with the Power of Artificial Neural Networks.

Water saturation plays a vital role in calculating the volume of hydrocarbon in reservoirs and defining the net pay. It is also essential for designing the well completion. Innacurate water saturation calculation can lead to poor decision-making, significantly affecting the reservoir's development and production, potentially resulting in reduced hydrocarbon oil recovery.

Pancreatic Fistula and Intraabdominal Fluid Collections after Distal Pancreatectomy: Incidence, Implications, and Natural History.

Objective: To investigate the incidence and management of pancreatic fistula and fluid collections (FC) after distal pancreatectomy (DP).

Summary Background Data: Pancreatic fistula and FC are common after DP. The relationship between pancreatic fistula, FC, and surgical drain placement remains unclear.

Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study.

Objective: This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).

Background: Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.

Methods: This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023.

Normothermic Liver Machine Perfusion At a Large European Center -Real World Outcomes Following 238 Applications.

Objective: To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic liver machine perfusion (NLMP) and compare to LT after static cold storage (SCS).

Background: NLMP is emerging as a clinical routine in LT as has recently received renewed attention, however outcomes outside of clinical trials are lacking.

Methods: All adult LT between February 2018 and January 2023 were included.

Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study.

Objective: This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) with acute pancreatitis (AP) on the severity and prognosis of patients, screen the risk factors of HFRS with AP, and establish a nomogram model.

Methods: Data were collected from HFRS patients at the First Affiliated Hospital of Dali University and Dali Prefecture People's Hospital (2013-2023). Patients were divided into HFRS with AP ( = 34) and HFRS without AP groups ( = 356).

Access to healthcare: waiting time until the surgical procedure.

Background: Understanding the determinants that limit the population's access to surgical care in health services is highly relevant in order to provide data to support political interventions.

Objective: This study aimed to evaluate the time between diagnosis and elective surgery in adult patients with the longest waiting lists in Brazil; identify the determinants that interfere with access to the health service to perform surgery; and analyze the quality of life after the indicative diagnosis of surgical intervention.

Methods: A cross-sectional study was conducted with adult patients treated at three hospitals in the Southeast, North and South regions of Brazil, from October 2020 to October 2022.