Anatomy, Biomechanics, and Pathogenesis of the Lesser Toes Deformities.

Deformities of the lesser toes are a prevalent condition faced by orthopedic surgeons. An imbalance between the extensor and flexor muscles might cause these deformities, affecting the metatarsophalangeal joint (MTPJ) and interphalangeal joint (IPJ). Therefore, a thorough understanding of the anatomy, biomechanics of the MTPJ, the surrounding structures, and the pathogenesis of lesser toe deformities is crucial for ensuring the correct diagnosis and treatment of the deformities.

Nurse prescription start-up in a Spanish health organization: Nurses' preparedness and 6-month results.

Introduction: Nurse prescribing is well consolidated in many countries. In Spain, recent legislation has allowed nurse to prescribe under specific conditions, but the implementation process is complex.

Objectives: First, to describe nurses' knowledge and expectations of nurse prescribing in a health institution in Spain.

Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.

Aims: To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF).

Methods And Results: A prospective, double-blind, placebo-controlled trial, including patients with AHF randomized to receive HCTZ or placebo in addition to an intravenous furosemide regimen. The coprimary endpoints were changes in body weight and patient-reported dyspnoea 72 h after randomization.

A Predictive Model and Risk Factors for Case Fatality of COVID-19.

This study aimed to create an individualized analysis model of the risk of intensive care unit (ICU) admission or death for coronavirus disease 2019 (COVID-19) patients as a tool for the rapid clinical management of hospitalized patients in order to achieve a resilience of medical resources. This is an observational, analytical, retrospective cohort study with longitudinal follow-up. Data were collected from the medical records of 3489 patients diagnosed with COVID-19 using RT-qPCR in the period of highest community transmission recorded in Europe to date: February-June 2020.

Open flap versus flapless placement of dental implants. A randomized controlled pilot trial.

The aim of this study was to compare the immediate postoperative period of participants rehabilitated with dental implants placed with a conventional technique or with a minimally invasive technique, without a mucoperiosteal flap elevation (flapless). Participants who needed implant placement were divided into two groups: one group was operated using a mucoperiosteal flap elevation (G_A), and the other with a flapless surgical technique (G_B). Objective clinical parameters including oral hygiene, mouth opening, inflammation (facial perimeter), surgical time and analgesic consumption, as well as subjective parameters of pain and degree of satisfaction with the procedure, were evaluated.

Autogenous teeth used for bone grafting: A systematic review.

Background: Recently, bone graft materials using permanent teeth have come to light, and clinical and histological outcomes of this material have been confirmed by some studies. The aim of this systematic review was to evaluate the reliability of the autogenous tooth bone graft material applied to alveolar ridge augmentation procedures.

Material And Methods: A systematic review of literature was conducted analyzing articles published between 2007 and 2017.

Taxane-Induced Peripheral Neurotoxicity.

Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells.

Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer.

Background And Aims: The prognostic value of the degree of apoptosis in colorectal cancer is controversial. This study evaluates the putative clinical usefulness of measuring caspase-3 activity as a prognostic factor in colonic cancer patients receiving 5-fluoracil adjuvant chemotherapy.

Materials And Methods: We evaluated caspase-3-like protease activity in tumours and in normal colon tissue.