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Androgenic anabolic steroid abuse and the cardiovascular system.
Handb Exp Pharmacol
February 2010
Chief Physician/Senior Cardiologist, Oslo University Hospital - Aker, Trondheimsveien 235, 0514-Oslo University Hospital, Oslo, Norway.
Article Synopsis
- Abuse of anabolic androgenic steroids (AAS) is associated with serious cardiovascular issues, including acute myocardial infarction and other significant conditions like left ventricular hypertrophy and sudden cardiac death.
- Research indicates that AAS can cause structural and functional changes in the heart, including altered diastolic function, increased heart chamber sizes, and mildly elevated blood pressure that may have limited clinical significance.
- AAS also disrupt lipid metabolism by increasing bad cholesterol (LDL) and decreasing good cholesterol (HDL), raising the risk of coronary artery disease among users.