[Tumor necrosis factor in the ejaculate as an indicator of reduced fertility].

Introduction: Pro-inflammatory cytokine - tumor necrosis factor-alpha (TNF) is one of the components of the seminal plasma proteome; its meaning has not been definitively revealed. A comparative analysis of the concentration of this protein in the blood serum and in the ejaculate and changes in its level in the semen of men with infertility is f scientific interest.

The Purpose Of The Study: determination of TNF- level in the blood serum and seminal plasma of healthy men and patients with reduced fertility.

[Thyroid cartilage fracture following sneezing as a cause of spontaneous pneumomediastinum].

Objective: To evaluate the possible etiological factors of spontaneous pneumomediastinum and to describe a case that was unusual in its etiology: a thyroid cartilage fracture as a result of sneezing.

Material And Methods: Six patients (four male, two female, aged 16-82 years) were hospitalized with spontaneous pneumomediastinum diagnosed with a chest X-ray in five patients and 100% with computed tomography. Treatment was symptomatic.

[Expert judgement of face profile].

Objective: The aim of the study is to determinate the values of the parameters of the face profile that ensure the harmony of the architectonics of the facial composition, taking into account sexual dimorphism.

Material And Methods: 22 independent orthodontists were invited as experts (11 men, average age is 36.8±1.

[Treatment approach to patients with distal malocclusion complicated by temporomandibular joint pain-dysfunction syndrome].

Objective: Research is effective sequencing of measures for orthodontic treatment active period and unfavorable course of retention period predictors in patients with distal malocclusion, complicated by temporomandibular joint pain-dysfunction syndrome.

Material And Methods: The retrospective study consists of 102 case reports of patients from 18 to 37 (average age is 26.75±3.

[Comparative characterization of the linear dimensions of the pubic symphysis in women in the first period of adulthood, elderly age and old age according to computed tomography data.].

The paper is based on the results of a CT study of 71 women with normal pelvic dimensions without pelvic bone or pelvic organ pathology who underwent the study in 2022-2023. All subjects consented to the study, which was performed according to the indications. The CT study consisted of determining the width, height, and thickness of the pubic symphysis in 3D reconstruction mode.

[Principles of complex dental caries treatment in children].

Unlabelled: The aim of the research is implementation, approbation and clinical efficiency estimation of treatment schemes of dental caries in children with different dental caries activity.

Materials And Methods: The study included 239 children aged 3 to 15 years (mean age 7.1±1.

[Evaluation of the dynamics of prosthetic dental care provided to patients with the complete absence of teeth in the Perm district].

Background: Currently, one third of the world's population aged 65-74 years has partially or completely missing teeth. In our country, the data of epidemiological studies are scattered.

Objective: The aim of the study is assessment of the dynamics of the volume of orthopedic care provided to patients with complete absence of teeth in the Perm Region.

Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation.

The protein glycodelin (PP14, PAEP) is associated with pregnancy and exhibits pronounced immunotropic properties. We studied the effect of glycodelin on the cytokine profile of blood serum during transplantation a suspension of allogeneic red bone marrow cells to Wistar rats. Recombinant glycodelin was administered to the animals 4 times (14 μg each time).

Comparative Content of Neuron-Specific Enolase in Human Blood Serum and Seminal Plasma.

We studied the content of neuron-specific enolase (NSE) in 69 paired samples of blood serum and seminal plasma from men with azoospermia (n=11) and oligoastenozoospermia (n=10) and from men with fertile ejaculate (n=48). NSE concentration was determined by ELISA (Vector-Best kit). The median concentration and the interquartile range of the NSE content in seminal plasma were 65.

Lactoferrin of oral fluid is normal and in Alzheimer's disease: laboratory and diagnostic aspects (review of literature).

The article discusses the clinical value of determining the lactoferrin protein in oral fluid - one of the representatives of the saliva proteome. The review is based on the analysis of modern literature, including systematic reviews, the results of multicenter prospective studies, review and original articles by leading experts in this field, presented in the databases PubMed, Scopus, CyberLeninka. The problems of the preanalytical stage, methods for determining lactoferrin are highlighted and information about its content in mixed saliva according to various authors is provided.

Express detection of Escherichia coli and bacteria of the Escherichia coli group at the oral cavity.

Currently, in the diagnosis of diseases, a decisive place is given to laboratory methods, which should be informative, relatively simple to perform and rapid. The article describes the approbation of a method for rapid detection of Escherichia coli and bacteria of Escherichia coli group in the oral cavity. Research involved 44 volunteers, who were sampled from the oral cavity, followed by incubation in Koda's medium.

[Urological complications of N.A. Nekrasovs disease].

to study the medical history of N.A. Nekrasov and to determine the nature of his urological disease.

[Morphological differences of the fallopian tube ampoule in young and old age.].

The work is based on a morphological study of ampoules of the fallopian tubes of 130 young and senile women who gave birth. Macrometric, histological, immunohistochemical and micrometric methods of investigation were applied. The regularities of age-related morphological variability of the fallopian tube ampoule are revealed, which are manifested in a decrease in the parameters of their length, as well as external diameters in the middle of the ampoule and at the places of transition of the isthmus into the ampoule and ampoule into the funnel from young age to old age.

[Key dental challenges during COVID-19 pandemic: oral health monitoring in patients with chronic oral mucosal diseases].

Objective: To develop an effective system of an interactive dynamic telemonitoring of oral health in patients with oral lichen planus (LP) during the COVID-19 pandemic.

Material And Methods: The observational longitudinal prospective cohort study (follow-up for 12 months) involved 53 patients (19 men and 34 women aged 49-65 years) with various forms of LP in persistent remission. During the entire observation period dentists carried out telemonitoring (through a Telegram group) of oral health of patients with LP registering the preservation/coming out from remission, as well as the causes of exacerbation of LP.

Readiness of clinical laboratory diagnostics and cardiologists to implement the recommendations of the fourth universal definition of myocardial infarction.

This study describes the problems of the implementation of the fourth universal definition of myocardial infarction in the medical institutions of four cities: Volgograd (with Volzhsky), Yekaterinburg, Perm, Ufa, and districts of the Volgograd region. The multicenter study was conducted in the form of a questionnaire of specialists in cardiology and laboratory services. After a survey of cardiac specialists, it was found that a third of them did not see the benefits of the hs-cTn test recommended for the diagnosis of myocardial infarction, and almost half of the specialists surveyed believed that myoglobin was a necessary test for detecting myocardial infarction.

[Quality of life of obese preschoolers].

The prevalence of obesity in childhood and adolescence tends to increase, and its presence is associated with a change in the quality of life (QOL). Nevertheless, the question of the influence of obesity on the QОL of Russian children in preschool years remains unexplored, while this age refers to the period of obesity manifestation. Purpose of the study - to examine the quality of life of preschool children with obesity and determine the optimal methods of disease preventing.

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»).

Aim      To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods  The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients' privacy (data of nasal and throat smears; antibody titer; typical CT imaging features).

[Effectiveness of treatment of elderly patients with traumatic brain injury complicated by subdural hematoma.].

The work is based on the results of a retrospective analysis of the medical records of 56 patients with traumatic brain injury complicated by acute subdural hematoma with a volume of 60-100 cm3. The patients were divided into 2 groups according to their age: the 1st group included 29 patients aged 22-29 years, the 2nd group consisted of 27 patients aged 61-69 years. The degree of impaired consciousness in the victims at admission to the clinic was evaluated on the Glasgow scale, the effectiveness of the treatment at discharge from the hospital was performed on the Rankin scale, assessing the degree of independence and disability.

[Comparative evaluation of the microstructure of combined samples made on the basis of acrylic plastic].

The Relevance Of The Study: Is dictated by the insufficient strength of the bases of removable plate prostheses made of acrylic plastic masses. The literature data confirm the high prevalence of strips of removable plate prostheses made of acrylic plastics, regardless of the complexity of the clinical situation, but in great dependence on the time of use of prostheses. The search for new approaches to reduce the risks of structural failures, regardless of the operating time, led to the emergence of a metal mesh and a composite frame.

[Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study].

Aim: To evaluate the analgesic effect, efficacy and tolerability of phenazopyridine in combination with fosfomycin for the treatment of acute uncomplicated cystitis in working-age female.

Material And Methods: A total of 152 women with acute uncomplicated cystitis were included in multicenter, randomized, open-label study which were carried out in 5 polyclinics of the Perm Territory. All the patients were divided into 2 groups of 76 people each, depending on the treatment.

Morphological and Immunohistochemical Features of the Heart under the Effect of Hydrogen Sulfide Balneotherapy.

The effects of hydrogen sulfide baths and sulfide-silt mud applications on the abdominal wall were studied in outbred white rats. Heart preparations stained with hematoxylin and eosin were analyzed and the mean numbers of cells expressing Ki-67, Nkx-2.5, and mesenchymal stem cell markers were determined.