Orofacial cleft research in Nigeria: a bibliometric analysis.

Orofacial cleft (OC) is a group of heterogeneous congenital abnormalities affecting the orofacial region. All over the world, several studies have been conducted on OC. This study aims to analyze OC research outputs in Nigeria.

Effect of a simulated patient cases software on the clinical competence of medical students during pediatric clerkship.

Simulation in medical education improves clinical competence. The Diagnostic Clinical Reasoning Program (DxR), a web-based simulated patient cases software, augments students' clinical skills in a virtual hospital setting. In the Arabian Gulf University, Bahrain, it is used to train medical students before they begin the clinical clerkship.

Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder - A link and an influence of DHEA?

Background: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders.

Methods: To investigate the impact of cortisol levels on within-session habituation of distress - a measure of success of exposure therapy - in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention.

Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone.

Background: Currently, there are no standardized guidelines for graft allocation in heart transplants (HTxs), particularly when considering organs from marginal donors and donors after cardiocirculatory arrest. This complexity highlights the need for an effective risk analysis tool for primary graft dysfunction (PGD), a severe complication in HTx. Existing score systems for predicting PGD lack superior predictive capability and are often too complex for routine clinical use.

Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives.

Coronary microvascular dysfunction (CMD) comprises a wide spectrum of structural and/or functional abnormalities of coronary microcirculation that can lead to myocardial ischemia. Emerging evidence has indicated that CMD is a relevant cause of morbidity and mortality and is associated with a high risk of major adverse cardiovascular events (MACEs) and heart failure with preserved ejection fraction as well as poor quality of life. This review aims to elucidate briefly the pathogenesis and diagnostic modalities of CMD and to shed light on contemporary evidence on the prognostic impact of CMD.

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudden cardiac death (SCD), making it a primary indication for heart transplantation. With advancements in modern medicine, several novel techniques for evaluating myocardial involvement and disease severity from diverse perspectives have been developed.

Laparoscopic Excision of a Large Intra-abdominal Cystic Lymphangioma in a Six-Month-Old Infant.

Lymphatic malformation is a rare vascular anomaly caused by abnormal lymphatic system development during embryogenesis. Intra-abdominal lymphatic malformations are uncommon in children, and surgical excision is considered the gold standard for treatment. However, few reports of minimally invasive laparoscopic approaches have been documented.

Recurrent Bacteremia in the Setting of Pseudomonas Endocarditis of the Tricuspid Valve and Indwelling Medical Devices.

This case report presents a complex and challenging scenario of recurrent () bacteremia and tricuspid valve endocarditis in a 77-year-old male patient with multiple comorbidities and indwelling medical devices. The patient's medical history was significant for T4 paraplegia, neurogenic bladder requiring a chronic indwelling suprapubic catheter, heart block status post-permanent pacemaker placement, type 2 diabetes mellitus, chronic kidney disease, and chronic sacral wounds. The case highlights the difficulties in managing antibiotic-resistant infections, particularly in patients with implantable devices and chronic wounds.

Transcutaneous Electrical Nerve Stimulation and Aerobic Exercise for Alcohol-Related Peripheral Neuropathy: A Case Report.

Alcohol use disorders can cause peripheral and central neurological disorders with symptoms such as pain, numbness, paresthesia, and dysesthesia, often impairing walking ability. However, effective treatments for alcohol-related peripheral neuropathy are yet to be identified. This case report highlights the successful use of dysesthesia-matched transcutaneous electrical nerve stimulation (DM-TENS) and aerobic exercise in a 53-year-old woman with alcohol-related peripheral neuropathy who presented with severe pain and walking difficulties.

Tracheal Pleomorphic Adenoma With Severe Airway Obstruction.

Pleomorphic adenoma of the trachea is a rare benign tumor, often challenging to diagnose due to nonspecific symptoms. We report a case of a 72-year-old female with a 10-year history of presumed bronchial asthma, presenting with persistent dyspnea. Preoperative assessment for breast cancer surgery revealed severe obstructive ventilatory impairment.

Antimicrobial Resistance Patterns of Clinically Isolated Strains of Acinetobacter baumannii in a Tertiary Care Hospital in Libya.

Objective:   accounts for a notable percentage of hospital-acquired infections. The widespread resistance to multiple antibiotic classes complicates treatment efforts. This study aims to find out the pattern of susceptibility of multidrug-resistant  (MDRAB) isolated from clinical specimens to antibiotics recommended for testing and use for and to determine a local guide at Tripoli University Hospital (TUH), Tripoli, Libya for the empirical antibiotic treatment of MDRAB based on the susceptibility pattern identified.

Acute Pancreatitis in Pregnancy and Puerperium: Assessing Maternal and Fetal Impact, Etiologies, and Clinical Outcomes at a Tertiary Care Hospital in Pakistan.

Introduction The association of acute pancreatitis with adverse obstetric outcomes remains subject to great controversy. Outcomes are affected by the standard of care available, and hence, will be better in developed countries than in underdeveloped countries like Pakistan. Therefore, this study aimed to understand the clinical characteristics and treatment of acute pancreatitis in pregnancy (APIP) and its associated maternal and neonatal outcomes in a tertiary care hospital in Pakistan.

Propranolol as a Novel Therapeutic Approach for Post-Stroke Anxiety: A Clinical Review and Future Directions.

Stroke remains a leading cause of death globally, with survivors facing both physical and psychological challenges. While acute stroke treatment has improved, many patients develop post-stroke anxiety (PSA), particularly generalized anxiety disorder. PSA represents a significant clinical challenge as most stroke survivors suffer from it.

A Case of Lepromatous Leprosy Presenting With Multiple Morphologies in Philadelphia.

Leprosy is an uncommon chronic mycobacterial infection in the United States caused by . There are two major forms of the infection, lepromatous leprosy and tuberculoid leprosy, with borderline forms of each. Leprosy is even more uncommon in the Northeastern United States and can present with various symptoms and skin findings, including erythematous or hypopigmented patches or plaques with accompanying hypoesthesia or anesthesia, anhidrosis, or alopecia.

Factors Associated With the Severity of Diabetic Ketoacidosis on Admission in Pediatric Intensive Care: A Retrospective Study.

Background Diabetic ketoacidosis (DKA) is one of the leading causes of morbidity and mortality in children with diabetes, often requiring intensive care unit management. This study aimed to identify factors associated with the severity of DKA in infants and children hospitalized in pediatric intensive care. Methodology This retrospective, monocentric, descriptive, analytical study included infants and children aged one month to 17 years who presented with DKA meeting the International Society for Pediatric and Adolescent Diabetes 2022 criteria.

Robot-Assisted Laparoscopic Resection With the Transanal Approach for Massive Rectal Gastrointestinal Stromal Tumor: A Case Report.

Rectal gastrointestinal stromal tumors (GISTs) are often asymptomatic and may be detected as giant tumors. This may require highly invasive surgery for radical resection. Here, we describe a 74-year-old man with a locally advanced non-metastatic GIST in the right anterolateral wall of the lower rectum.

Correlation of Dental and Periodontal Status With HIV Presence and Initial CD4 Counts: An Albanian Prospective Observational Study.

Background Different pathologies are encountered more often in human immunodeficiency virus (HIV)-infected patients, such as bacterial, fungal, viral infection, and neoplastic diseases. Recently, studies have shown that HIV-infected individuals have poorer oral health outcomes, worse dentition, and aggressive forms of periodontitis. This study aims to investigate the dental and periodontal status of HIV-infected patients, the correlation between CD4+ level and the CD4 percentage with dentition, and periodontal status.

Factors Associated With Rebleeding and Early Mortality Following Transcatheter Arterial Embolization for Spontaneous Muscle Hematoma: A Single-Center Experience Including the Period of the Coronavirus Disease Pandemic.

Objectives We aim to investigate factors associated with rebleeding and mortality within one month of transcatheter arterial embolization (TAE) for spontaneous muscle hematoma (SMH) and the impact of the novel coronavirus disease 2019 (COVID-19). Methods This retrospective analysis included 33 patients who underwent TAE for SMH at a single center between 2012 and 2022. After 2020, eight of these patients had the COVID-19 infection.

Mechanical Thrombectomy in Africa: A Challenging Future.

Mechanical thrombectomy (MT) has revolutionized the management of proximal large vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS), improving long-term outcomes compared to standard treatments. However, despite its success in high-income countries, the widespread implementation of MT in Africa remains limited. With Africa experiencing one of the highest stroke burdens globally, this study examines the barriers impeding the adoption of MT in the region.

Combined Proteasome and Autophagy Inhibition in Relapsed/Refractory Multiple Myeloma-A Phase I Trial of Hydroxychloroquine, Carfilzomib, and Dexamethasone.

Multiple myeloma is characterized by malignant cells which produce high amounts of monoclonal immunoglobulin. Myeloma cells are, therefore, dependent on effective protein degradation. Proteasomal protein degradation is targeted by proteasome inhibitors in routine care.

The long-term risk of immune-related conditions in survivors of diffuse large B-cell lymphoma: A Danish nationwide registry study.

Background: There is limited knowledge of the long-term effects on the immune system after treatment for diffuse large B-cell lymphoma (DLBCL).

Methods: This study included DLBCL patients from the Danish Lymphoma Registry who obtained complete remission (CR) after (R)-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone)-like immunochemotherapy. Each R CHOP-like treated patient was matched to five comparators from the Danish background population and furthermore compared to R CHOP-like treated patients.

A novel TERT variant associated with a telomere biology disorder and challenges in variant classification.

Telomere biology disorders (TBDs) are inherited conditions associated with multisystem manifestations. We describe clinical and functional characterisation of a novel TERT variant. Whole-genome sequencing was performed along with single length analysis ().

Uptake of the first to fifth doses of coronavirus disease 2019 vaccine in individuals with chronic lymphocytic leukaemia: A nationwide cohort study in Sweden.

Objectives: Patients with chronic lymphocytic leukaemia (CLL) have an increased risk of severe coronavirus disease 2019 (COVID-19) as well as impaired responses to COVID-19 vaccination, which may be overcome by repeated booster vaccinations. Our objective was to explore the uptake of the COVID-19 vaccine in this population since records of this are scarce.

Methods: In this nationwide cohort study, we used multiple population-based health and sociodemographic registries to study COVID-19 vaccine uptake in individuals with CLL in Sweden, from 27 December 2020 to 28 February 2023.

HLA-matched related peripheral blood stem cell and bone marrow transplantation with RIC regimens yield comparable outcomes for adult AML.

Introduction: Understanding differences in clinical outcomes between PBSCT and BMT is important, and this study compared outcomes of HLA-matched related PBSCT and BMT using reduced-intensity conditioning (RIC) in adult acute myeloid leukemia (AML) patients.

Methods: Data from 402 patients who underwent either PBSCT ( = 294) or BMT ( = 108) between 2000 and 2022 were analyzed using the Japanese nationwide registry database. The primary endpoint was overall survival (OS), and secondary endpoints included disease-free survival (DFS), non-relapse mortality (NRM), and GVHD.