4 results match your criteria: "Рeoples' Friendship University of Russia (RUDN University)[Affiliation]"
Advances in synthesis of novel annulated azecines and their unique pharmacological properties.
Eur J Med Chem
December 2024
Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy. Electronic address:
Article Synopsis
- * The complexity in synthesizing these benzazecine structures has limited their study in organic and medicinal chemistry, despite their promising pharmacological activities.
- * This review highlights recent advancements in the synthetic methods for arene-fused azecine derivatives and their potential as versatile drug scaffolds, particularly for developing treatments for mental disorders, cancer, and neurodegenerative diseases.
Traveling across Life Sciences with Acetophenone-A Simple Ketone That Has Special Multipurpose Missions.
Molecules
January 2023
Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, Cl. 9 # Cra 27, A.A., Bucaramanga 680006, Colombia.
Each metabolite, regardless of its molecular simplicity or complexity, has a mission or function in the organism biosynthesizing it. In this review, the biological, allelochemical, and chemical properties of acetophenone, as a metabolite involved in multiple interactions with various (mi-cro)organisms, are discussed. Further, the details of its biogenesis and chemical synthesis are provided, and the possibility of its application in different areas of life sciences, i.
View Article and Find Full Text PDFCo-limitation towards lower latitudes shapes global forest diversity gradients.
Nat Ecol Evol
October 2022
Centre for Invasion Biology, Department of Mathematical Sciences, Stellenbosch University, Matieland, South Africa.
Article Synopsis
- The latitudinal diversity gradient (LDG) reflects a global trend showing that species richness typically increases towards the tropics, but understanding its causes has been challenging due to insufficient data.
- A new high-resolution map of local tree species richness was created using extensive global forest inventory data and local biophysical factors, analyzing around 1.3 million sample plots.
- Findings indicate that annual mean temperature is a significant predictor of tree species richness, aligning with the metabolic theory of biodiversity, but additional local factors also play a crucial role, especially in tropical regions.
Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data.
Nat Biotechnol
February 2021
Department of Surgery and Cancer, Imperial College London, South Kensington Campus, London, UK.
We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas chromatography-mass spectrometry (GC-MS) data. We then designed workflows to enable the community to store, process, share, annotate, compare and perform molecular networking of GC-MS data within the Global Natural Product Social (GNPS) Molecular Networking analysis platform. MSHub/GNPS performs auto-deconvolution of compound fragmentation patterns via unsupervised non-negative matrix factorization and quantifies the reproducibility of fragmentation patterns across samples.
View Article and Find Full Text PDF