Increased SCUBE-1 levels in the aqueous humour of patients with pseudoexfoliation syndrome.

Clinical Relevance: Pseudoexfoliation syndrome (PXS) is a common age-related disorder associated with glaucoma and cataract. Despite its clinical importance, the pathogenesis of PXS is not yet fully understood.

Background: To evaluate levels of SCUBE-1 (signal peptide, CUB domain, and epidermal growth factor-like domain containing protein 1) in the serum and aqueous humour of patients with PXS in comparison with non-PXS controls.

Evaluation of double-balloon enteroscopy in the management of type 1 small bowel vascular lesions (angioectasia): a retrospective cohort study.

Background: Small-bowel angioectasia is commonly diagnosed and managed using double-balloon enteroscopy; however, rebleeding rates can vary significantly. This study aimed to identify and evaluate the clinical predictors of rebleeding in patients with small-bowel angioectasia.

Methods: This retrospective study focused on adult patients who underwent endoscopic management for small bowel vascular lesions (SBVLs).

Experiences of first-time fathers in the transition to parenting: A qualitative study.

Problem: Despite cultural or individual differences, fathers have difficulty finding a role in the parenting process, they feel inadequate in baby care and they think they are excluded by health personnel.

Background: Little is known about how first-time fathers perceive their experiences, needs, and fatherhood roles during their transition to parenthood.

Objective: This study was conducted to understand the experiences, needs and fatherhood roles of first-time fathers in the transition to parenthood.

Endoscopic butterfly cartilage myringoplasty: our long term results.

Background: Myringoplasty is one of the treatments used for perforated tympanic membrane.

Aim/objective: We aimed to evaluate the long-term anatomical and functional outcomes of patients who underwent endoscopic inlay butterfly cartilage myringoplasty.

Material And Methods: We retrospectively analyzed 74 patients who had undergone endoscopic butterfly cartilage myringoplasty were followed for at least five years.

Creation of a Tibia Extension Model With a Perforated Ilizarov Ring System: An Experimental Study in Rats.

Distraction osteogenesis is a valuable clinical technique used to address length discrepancies in long bone deformities. This procedure involves performing an osteotomy at an appropriate site in the bone and correcting the deformity through an extension system. This research aims to investigate the efficacy of a newly developed device for use in rat tibias and to provide an alternative to existing devices used in animal experiments.

Comparison of Stump Closure Methods in Laparoscopic Appendectomy: Hem-o-Lok Clip and Laparoscopic Titanium Clip.

Background: Appendectomy for acute appendicitis is the most common acute abdominal surgery. Open and laparoscopic appendectomy surgeries are performed with different techniques. Laparoscopic appendectomy has become a widespread method due to its advantages.

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps.

Objective: Inflammatory processes play a role in the etiopathogenesis of chronic rhinosinusitis. Many gene polymorphisms have been associated with inflammation. In this study, we aimed to examine the relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and chronic rhinosinusitis.

The relationship between HPV-Associated LSIL and HSIL lesions and overactive bladder in postmenopausal women.

Objective: This study aims to investigate the relationship between HPV-associated LSIL and HSIL lesions and overactive bladder (OAB) symptoms in postmenopausal women, highlighting the role of severe histopathological lesions.

Materials And Methods: A retrospective analysis was conducted on postmenopausal women aged 40-65 years who presented at Istanbul Bakırköy Sadi Konuk Training and Research Hospital between January 2021 and March 2023. The study included HPV-positive patients with low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL), as well as HPV-negative controls.

Investigation of corneal topographic and ocular surface parameters in ocular rosacea based on skin subtypes.

Objective: To compare the corneal topographic parameters and ocular surface parameters of ocular rosacea (OR) patients across skin subtypes of the disease and healthy controls.

Methods: This prospective study included 180 eyes of 90 OR patients and 60 eyes of 30 healthy controls. Among the OR patients, 30 had phymatous (60 eyes), 30 had erythematotelangiectatic (60 eyes) and 30 had papulopustular skin types (60 eyes).

Recovery of Myocardial Functions After Kidney Transplantation in Patients with Heart Failure Due to Uremic Cardiomyopathy.

Objective: Although left ventricular hypertrophy frequently accompanies end-stage renal disease, heart failure (HF) with reduced ejection fraction (EF) is also observed in a subset of patients. In those patients kidney transplantation (KT) is generally avoided due to an increased risk of mortality in addition to the risks associated with HF. This prospective study was designed to follow patients with HF who were being prepared for KT.

Comparative Evaluation of Chatbot Responses on Coronary Artery Disease.

Objective: Coronary artery disease (CAD) is the leading cause of morbidity and mortality globally. The growing interest in natural language processing chatbots (NLPCs) has driven their inevitable widespread adoption in healthcare. The purpose of this study was to evaluate the accuracy and reproducibility of responses provided by NLPCs, such as ChatGPT, Gemini, and Bing, to frequently asked questions about CAD.

Regorafenib Treatment for Recurrent Glioblastoma Beyond Bevacizumab-Based Therapy: A Large, Multicenter, Real-Life Study.

Background/objectives: In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate the effectiveness and safety of regorafenib as a third-line treatment for patients with recurrent glioblastoma who progressed while taking bevacizumab-based therapy.

Methods: This retrospective, multicenter study in Turkey included 65 patients treated between 2021 and 2023 across 19 oncology centers.

Maternal Perception and Childhood Overweight: Examining Parenting Styles and Eating Behaviors Among Preschoolers: A Cross-Sectional Study from Samsun, Türkiye.

Background: Accurate maternal perceptions of children's weight status are crucial for early childhood obesity prevention, with evidence suggesting that maternal misperception may delay timely interventions. This study investigated the accuracy of maternal perceptions of child weight and examined associations with parenting styles and children's eating behaviors and demographic factors among preschool-aged children in Samsun, Türkiye.

Methods: This cross-sectional study included 318 mother-child pairs recruited from preschools in socio-economically diverse areas of Samsun.

Long-Term Effects of COVID-19 on Optic Disc and Retinal Microvasculature Assessed by Optical Coherence Tomography Angiography.

: To evaluate the long-term effects of coronavirus disease (COVID-19) on optic disc and macular microvasculature. : 40 post-COVID-19 and 40 healthy subjects were included. Optical coherence tomography angiography (OCTA) was performed for all subjects at the first visit and repeated in the fourth and twelfth months.

The Prognostic Value of Total Blood Count Parameter Ratios in Acute Pulmonary Embolism.

Acute pulmonary embolism (PE) is a leading cause of cardiovascular mortality, characterized by nonspecific symptoms and variable clinical presentations. Accurate risk stratification is essential for effective management. While conventional tools like the simplified pulmonary embolism severity index (sPESI) and imaging modalities are widely used, they are often costly and have limitations in predictive accuracy.

Sleeve gastrectomy with antral resection provides more effective weight loss in patients with super obesity.

Background: Obesity is a growing health issue that contributes to numerous diseases and lowers quality of life. In patients with super obesity (BMI > 50 kg/m²), bariatric surgery, particularly laparoscopic sleeve gastrectomy (LSG), is a common treatment option. However, the role of antral resection (AR) in LSG remains unclear, especially in this high-risk population.

Invited Response on: Comment on ''The Impact of Duration and Force of Centrifugation on Platelet Content and Mass in the Preparation of Platelet-Rich Plasma''.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.

Femoral Component Malrotation Following Total Knee Arthroplasty in the Presence of Hypoplasia: Is the Orthopedic Surgeon Aware?

Background This study hypothesizes that patients with femoral condylar hypoplasia who undergo total knee arthroplasty (TKA) may experience femoral component malrotation and that the surgeon performing the operation may not notice it. The aim is to measure the rotational alignment of the femoral components and assess the functional outcomes in these patients. Materials and methods Between December 2018 and December 2022, a total of 96 knees from 80 patients were evaluated.

The imposter phenomenon in psychiatrists: relationships among compassion fatigue, burnout, and maladaptive perfectionism.

Background: The imposter phenomenon is the unwillingness to acknowledge one's triumphs, which is common among doctors. Research on the imposter phenomenon among mental health professionals is limited, and the relationship between imposter phenomenon, burnout, and compassion fatigue has not been studied. The current study intended to test a hypothesized model of the specific impact paths among burnout, compassion fatigue, maladaptive perfectionism, and imposter phenomenon among mental health professionals.