Enhanced Dissipation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Soil by the Bioaugmentation with Newly Isolated Strain MC5.

The presented study investigated the possibility of using the MC5 strain, isolated from raw sewage by the enrichment culture method, in the bioremediation of soil contaminated with selected NSAIDs, i.e., ibuprofen (IBF), diclofenac (DCF), and naproxen (NPX), using the bioaugmentation technique.

Hybrid Systems of Oleogels and Probiotic-Loaded Alginate Carriers for Potential Application in Cosmetics.

Oleogels (organogels) are systems resembling a solid substance based on the gelation of organic solvents (oil or non-polar liquid) through components of low molecular weight or oil-soluble polymers. Such compounds are organogelators that produce a thermoreversible three-dimensional gel network that captures liquid organic solvents. Oleogels based on natural oils are attracting more attention due to their numerous advantages, such as their unsaturated fatty acid contents, ease of preparation, and safety of use.

Energetic Coordination Compounds: Investigation of Aliphatic Ligands and Development of Prototype Detonators.

In this work, energetic coordination compounds (ECCs) of transition metals (Fe, Ni, Cu, Zn) containing aliphatic amines as ligands were synthesized: ethylenediamine; 1,3-diaminopropane; tris(2-aminoethyl)amine; tris(3-aminopropyl)amine. The compounds were investigated in terms of ignition/explosion temperature, friction and impact sensitivity. For selected compounds, structural characterisation was presented (IR-ATR spectroscopy, Raman spectroscopy) and their morphology was determined (SEM, powder XRD).

Ti/CuO Nanothermite Doped with Secondary Energetic Materials: A Study of Combustion Parameters.

Nanothermites have found broad applications; however, due to being systems largely reacting in condensed phases, their performance is somewhat limited by heat and mass transfer. In order to alleviate this issue, nanothermites doped with gas-generating energetic materials have been developed. In this work, we present an investigation of a model Ti/CuO nanothermite doped by four classical energetic materials and investigate their properties and combustion performance.

Analysis of the and Splice Variants' Expression Profile under In Vitro Differentiation of Human Mesenchymal Bone Marrow Cells into Osteoblasts.

Bone formation is a complex process regulated by a variety of pathways that are not yet fully understood. One of the proteins involved in multiple osteogenic pathways is TID (DNAJA3). The aim of this work was to study the association of TID with osteogenesis.

Comparison of two biological systems used for phototoxicity testing: Cellular and tissue.

The OECD has approved two similar methods for testing the phototoxic potency of chemicals. The first method, OECD 432, is based on the cytotoxicity properties of materials to the mouse 3T3 (clone A31) cell line (fibroblasts) after exposure to light. The second method, OECD 498, is based on the same properties but using reconstructed human epidermis - EpiDerm (stratified keratinocytes).

Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles.

The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug candidates design and development. The lipophilicity of compounds was determined using the computational (log P) and chromatography (log k, R) methods.

Comprehensive study on impact of hydrogen peroxide decomposition on the crucial parameters of OSM-type energetic materials.

The use of increasingly advanced energetic materials (EMs) in various branches of industry and military sectors increases the appropriate requirements for EMs, including: their durability, safety of use, chemical and high-energetic properties. Additionally, the impact of the products of the explosion of EMs on the natural environment is also crucial. Therefore, on-site mixture (OSM) energetic materials containing concentrated hydrogen peroxide (OSM-type energetic materials) are becoming increasingly popular.

Pyrotechnic Delay Compositions Based on BaO: Not as "Green" as Expected.

The aims of this study were to investigate the potential of using barium peroxide as an environmentally friendly oxidising agent, to evaluate the composition of the combustion products of the developed pyrotechnic delay compositions (PDCs) and to provide information about the impact of the utilised metallic fuel (Mg, Al, Fe or Cu) on the properties of those PDCs. The PDCs exhibited acceptable friction and impact sensitivity values. This allowed conducting further experiments, e.

Study of the Combustion Mechanism of Zn/KMnO Pyrotechnic Composition.

This work aims to investigate the combustion mechanism for a pyrotechnic delay composition (PDC), consisting of zinc powder as a fuel and KMnO as an oxidising agent. For this purpose, the compositions were thermally conditioned at several set temperatures, chosen based on our previous work. Tests were also performed for post-combustion residues obtained via combustion of the PDCs in a manometric bomb.

Towards "Green" ANFO: Study of Perchlorates and Inorganic Peroxides as Potential Additives.

Ammonium nitrate-fuel oil (ANFO) explosives are inexpensive and readily produced, but are highly prone to misfires, with the remaining explosive being a significant risk and environmental contaminant. In this work, studies on various additives, such as selected perchlorates and inorganic peroxides, which are intended to lower the susceptibility of ANFO to misfires by increasing its sensitivity to shock, have been conducted. These studies showed the viability of using these additives in ANFO, allowing for conducting shock wave sensitivity tests for bulk charges in the future.

Research on Explosive Hardening of Titanium Grade 2.

In this investigation, three different explosive materials have been used to improve the properties of titanium grade 2: ammonal, emulsion explosives, and plastic-bonded explosives. In order to establish the influence of explosive hardening on the properties of the treated alloys, tests were conducted, including microhardness testing, microstructure analysis, and tensile and corrosion tests. It has been found that it is possible to achieve a 40% increase in tensile strength using a plastic explosive (PBX) as an explosive material.

Alternative Methods for Skin-Sensitization Assessment.

Skin sensitization is a term used to refer to the regulatory hazard known as allergic contact dermatitis (ACD) in humans or contact hypersensitivity in rodents, an important health endpoint considered in chemical hazard and risk assessments. Information on skin sensitization potential is required in various regulatory frameworks, such as the Directive of the European Parliament and the Council on Registration, Evaluation and Authorization of Chemicals (REACH). The identification of skin-sensitizing chemicals previously required the use of animal testing, which is now being replaced by alternative methods.

Investigation of Combustion of KMnO/Zn Pyrotechnic Delay Composition.

This article reports an investigation of the combustion of a binary pyrotechnic delay composition (PDC), consisting of zinc powder as fuel and KMnO as an oxidising agent, with zinc content ranging from 35 to 70 wt. %. The linear burning rate for delay compositions in the form of pyrotechnic fuses was investigated.

Quo Vadis, Nanothermite? A Review of Recent Progress.

One of the groups of pyrotechnic compositions is thermite compositions, so-called thermites, which consist of an oxidant, usually in the form of a metal oxide or salt, and a free metal, which is the fuel. A characteristic feature of termite combustion reactions, apart from their extremely high exothermicity, is that they proceed, for the most part, in liquid and solid phases. Nanothermites are compositions, which include at least one component whose particles size is on the order of nanometers.

Cytotoxicity assay to assess eye irritation - A comparison with other methods and possible strategies for use.

Many in vitro methods can be used to classify eye irritation or damage caused by exposure to a substance. In this study, a recently described method called the Cytotoxicity Assay to Assess Eye Irritation (CEI) was compared with other selected in vitro methods adopted in the OECD guidelines. Furthermore, the influence of combining more than one in vitro method was investigated.

Expression Profile of Selected Genes Involved in Storage Lipid Synthesis in a Model Oleaginous Yeast Species .

yeast is a model species of the group of oleaginous microorganisms capable of intracellular lipids accumulation in an amount exceeding 20% of the dry mass. Single cell oil biosynthesis can follow one of two biochemical pathways-de novo accumulation of cellular lipids in medium containing non-lipid carbon sources (including saccharides, glycerol) and ex novo microbial oil synthesis which involves fatty acids uptake from the environment. The mRNA expression of selected genes of de novo and ex novo lipid synthesis pathways was analyzed and correlated with the phenotypically observed features.

Developing a screening test for toxicity studies of prenatal development with the use of and embryos of zebrafish.

11 active substances used in pesticides were selected. Substances were divided into three groups depending the effect on embryos or fetuses of laboratory animals: 1 - damaging effect on embryos or fetuses (embryotoxic, fetotoxic or teratogenic), 2 - damaging effect on embryos or fetuses, but only at dose toxic for mother (maternal toxicity), 3 - no damaging effect. Changes for hydra in acute toxicity tests and recovery tests were assessed on an change scale from 0 to 10.

Theft-Safe Explosive Mixtures Based on Hydrogen Peroxide: Study of Properties and Built-In Self-Deactivation Kinetics.

The current focus on both environmental and general safety is an important issue in the field of explosives. As such, environmentally-friendly explosives, based on hydrogen peroxide (HTP) as an oxidising agent, are of significant interest. These explosives can be designed to undergo self-deactivation, denying access to them by any unlawful third parties that may attempt scavenging blasting sites for any residual energetic materials.

Olanzapine Increases Neural Chemorepulsant-Draxin Expression in the Adult Rat Hippocampus.

Draxin belongs to the family of inhibitory axon-guiding factors that regulate neuronal migration and axonal spreading in the developing brain. This glycoprotein has recently been considered to play an important role both in hippocampal differentiation and adult neurogenesis in the dentate gyrus. Given that it has been reported that antipsychotic drugs may affect neurite growth and neurogenesis, we have therefore investigated whether chronic treatment with olanzapine modulates draxin immunoreactivity in the adult rat hippocampus.

Studies on Upgradation of Waste Fish Oil to Lipid-Rich Yeast Biomass in Batch Cultures.

The aim of the study was to evaluate the possibility to utilize a fish waste oil issued from the industrial smoking process in nitrogen-limited yeast batch cultures. The waste carbon source was utilized by the yeast and stimulated the single cell oil production via an ex novo pathway. The yeast biomass contained lipids up to 0.

Enzymatic Synthesis of Lipophilic Esters of Phenolic Compounds, Evaluation of Their Antioxidant Activity and Effect on the Oxidative Stability of Selected Oils.

The aim of the study was to compare the effect of the substituent and its position in the aromatic ring on the antioxidant activity of hexanoic acid esters obtained in reactions catalyzed by immobilized lipase B from . 4-Hydroxybenzyl hexanoate, 2-hydroxybenzyl hexanoate, 4-methoxybenzyl hexanoate, and vanillyl hexanoate were obtained with conversion yields of 50 to 80%. The antioxidant activity of synthesized esters, their alcohol precursors and BHT (Butylated HydroxyToluene) was compared with DPPH (2,2-diphenyl-1-picrylhydrazyl), CUPRAC (cupric ion reducing antioxidant capacity), and CBA (crocin bleaching assay) methods.

Essential oils and their components in combating fungal pathogens of animal and human skin.

Objective: The most common problems of modern medicine include fungal infections of the skin and its appendages caused by dermatomycetes, yeast-like fungi and moulds. Due to toxicity of pharmacological fungicides and promotion of ecology, natural substances with high antifungal properties are sought. Essential oils and their components show potential in this regard.

Biological evaluation and molecular docking of novel 1,3,4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors.

Two series of novel 1,3,4-thiadiazole-resorcinol conjugates were efficiently synthesized and evaluated as cholinesterases inhibitors. N-Butyl- and N-chlorophenyl-5-amino-1,3,4-thiadiazol-2-yl)benzene-1,3-diols were identified as the most promising compounds of low nanomolar activity against AChE (IC = 29-76 nM) and moderate activity against BuChE. The inhibition mechanism studies proved that the compounds are mixed type inhibitors.

A proposal for a new in vitro method for direct classification of eye irritants by cytotoxicity test - Preliminary study.

None of the in vitro method are suitable for directly classifying of a substance as an eye irritant (category 2). They can classify substance as category 1 (serious eye damage) or as "no category" (not requiring classification). The aim of this study was to develop a new method for direct classification of a substance as category 2.