Comparison of the biomechanical effect of distal implants placed at different angles in the all-on-four technique: A nonlinear finite element analysis.

Introduction: The "All-on-four" technique addresses this by placing two vertical implants in the anterior region and two posterior implants angled up to 45°. This study evaluates stress distribution on bone, implants, abutments, gingiva, and prostheses based on posterior implant angulation, using both standard and angled neck implants. Additionally, angled neck implants were used alongside standard implants.

Expression and Localization of Adiponectin in Myoepithelial Cells in Sublingual Glands of Normal and Diabetic Rats.

Objectives: Adiponectin is a hormone produced by adipocytes with anti-atherosclerotic and anti-diabetic properties. We previously discovered that adiponectin is specifically localized in the myoepithelial cells of rat sublingual glands. This study aims to investigate the localization of adiponectin and its receptors, AdipoR1 and AdipoR2, in adult rats, postnatally developing rats, and diabetic model rats.

Oxytocin Receptor Polymorphism Is Associated With Sleep Apnea Symptoms.

Context: Oxytocin supplementation improves obstructive sleep apnea (OSA), and animal studies suggest involvement of oxytocin in respiratory control. However, the relationship between endogenous oxytocin signaling and human sleep status remains undetermined.

Objective: In this study, we approached the contribution of the intrinsic oxytocin-oxytocin receptor (OXTR) system to OSA by genetic association analysis.

C-terminal tagging enhances the detection sensitivity of interlekin receptor type 1.

Substances released outside of the cells during cell necrosis are collectively called danger-associated molecular patterns (DAMPS) or alarmins. A pro-inflammatory cytokine, interleukin-1α (IL-1α) is known as a typical alarmin. IL-1α transmits signals by binding to IL-1 receptor 1 (IL-1R1), type I protein, expressed on the cell membrane of target cells, but detection of IL-1R1 at the protein and mRNA levels is difficult.

Immediate implant placement in compromised extraction sockets using vestibular socket therapy with acellular dermal matrix versus connective tissue grafts in the esthetic zone: a randomized controlled clinical trial.

Background: Immediate implant placement (IIP) in compromised extraction sockets poses significant challenges in maintaining the contour and level of mucosal tissues. This study compares the efficacy of vestibular socket therapy (VST) combined with acellular dermal matrix (ADM) versus connective tissue grafts (CTG) in IIP within the esthetic zone.

Methods: Twenty participants requiring extraction in the maxillary esthetic zone were randomized into two groups: ADM and CTG (n = 10 each).

Teledentistry for Pediatric Dental Emergency: Comparison Between Experienced and Novice Users.

Background: During the COVID-19 pandemic, teledentistry was often employed for pediatric emergency treatments. Dental students acted as the first health providers using teledentistry under the supervision of faculties in most hospital-based or university-based medical centers during the lockdown period. The aims of this study were to assess the quality of using teledentistry among general dentists (GDs) and dental students (DSs) for managing pediatric dental emergencies.

Bioactive Compounds Enhance the Biocompatibility and the Physical Properties of a Glass Ionomer Cement.

In order to characterize a novel restorative material, knowledge about the toxicological effect on human cells and the physical behavior of a glass ionomer cement (GIC) containing flavonoids was established. The flavonoids apigenin, naringenin, quercetin, and liquiritigenin were manually incorporated into a GIC. In the control group, no incorporation was performed.

Accuracy of One-Piece vs. Segmented Three-Dimensional Printed Transfer Trays for Indirect Bracket Placement.

Objective: To assess the accuracy of three-dimensional (3D) printed one-piece vs. multiple segmented transfer trays for indirect bonding techniques in moderate and severe crowding cases.

Methods: Eighty digital maxillary dental models were produced by an extraoral scanner.

A New Multi-Axial Functional Stress Analysis Assessing the Longevity of a Ti-6Al-4V Dental Implant Abutment Screw.

This study investigates the impact of tightening torque (preload) and the friction coefficient on stress generation and fatigue resistance of a Ti-6Al-4V abutment screw with an internal hexagonal connection under dynamic multi-axial masticatory loads in high-cycle fatigue (HCF) conditions. A three-dimensional model of the implant-abutment assembly was simulated using ANSYS Workbench 16.2 computer aided engineering software with chewing forces ranging from 300 N to 1000 N, evaluated over 1.

Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways.

Bmi1 is a polycomb protein localized in stem cells and maintains their stemness. This protein is also reported to regulate the expression of various differentiation genes. In this study, to analyze the role of Bmi1 during dentinogenesis, we examined the immunohistochemical localization of Bmi1 during rat tooth development as well as after cavity preparation.

Clinical Utility and Safety of an Ultrasonic Head Stimulator in Dementia With Lewy Bodies.

Background: The potential of Ultra-Ma, an ultrasonic head stimulator, for the supplementary treatment of dementia with Lewy bodies (DLB) was evaluated in patients with various symptoms under poor control by drug therapy.

Methods: Patients with DLB treated with choline esterase inhibitor or L-DOPA, either alone or in combination, and who met inclusion criteria were enrolled. Four weeks of placebo stimulation was followed by 8 weeks of active ultrasonic stimulation and a 4-week follow-up.

Artificial Insemination as a Possible Convenient Tool to Acquire Genome-Edited Mice via In Vivo Fertilization with Engineered Sperm.

Advances in genome editing technology have made it possible to create genome-edited (GE) animals, which are useful for identifying isolated genes and producing models of human diseases within a short period of time. The production of GE animals mainly relies on the gene manipulation of pre-implantation embryos, such as fertilized eggs and two-cell embryos, which can usually be achieved by the microinjection of nucleic acids, electroporation in the presence of nucleic acids, or infection with viral vectors, such as adeno-associated viruses. In contrast, GE animals can theoretically be generated by fertilizing ovulated oocytes with GE sperm.

Effects of initial periodontal therapy on leucine-rich alpha-2 glycoprotein levels in saliva from Japanese patients with chronic periodontitis.

Purpose: Examination of patients to detect periodontal disease is important for diagnosis and treatment planning, and accuracy of examination may be improved if salivary components can be applied for diagnosis. Leucine-rich α2 glycoprotein (LRG) is expressed in the serum of patients with inflammatory diseases, and salivary LRG may be applicable to the diagnosis of periodontal disease.

Methods: To evaluate the effect of initial periodontal therapy (IPT) on clinical periodontal parameters such as probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), periodontal inflamed surface area (PISA), periodontal epithelial surface area (PESA), saliva samples were collected before and after IPT from 63 patients with chronic periodontitis.

Antiferroptotic properties of allicin and related organosulfur compounds-diallyl disulfide and diallyl trisulfide-from Garlic.

Allicin (diallyl thiosulfinate) is an abundant bioactive compound in garlic (Allium sativum L.) with broad-spectrum antiinflammatory, antifungal, antioxidant, and antitumor properties. The bioactive compounds of garlic including allicin may also help reduce the incidence of various diseases, although the individual contributions and precise mechanisms are still largely unknown.

Astrocytic inhibition of lateral septal neurons promotes diverse stress responses.

Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca²⁺ levels in response to aversive sensory and social stimuli in both male and female mice.

A personalized periodontitis risk based on nonimage electronic dental records by machine learning.

Objective: This study aimed to develop a machine-learning (ML) model to predict the risk for Periodontal Disease (PD) based on nonimage electronic dental records (EDRs).

Methods: By using EDRs collected in the BigMouth repository, dental patients from the US were included. Patients were labeled as cases or controls, based on PD diagnosis, treatment and pocketing.

Thrombopoietic agents enhance bone healing in mice, rats, and pigs.

Achieving bone union remains a significant clinical dilemma. The use of osteoinductive agents, specifically bone morphogenetic proteins (BMPs), has gained wide attention. However, multiple side effects, including increased incidence of cancer, have renewed interest in investigating alternatives that provide safer, yet effective bone regeneration.

Effect of Zinc on improving silver diamine fluoride-derived tooth discoloration in vitro.

Background: Silver Diamine Fluoride (SDF) is effective for arresting dental caries, presenting a valuable non-invasive treatment option in dentistry. Despite its therapeutic advantages, a significant drawback is the tooth discoloration that follows its application, which can affect patient acceptance. Addressing this aesthetic concern without diminishing the treatment's efficacy remains challenging in dental practice.

Effects of phototherapy in patients with idiopathic facial palsy: Scoping review.

Phototherapy has emerged as a promising treatment for Bell's palsy, offering potential improvements in facial nerve function and overall well-being. In this study, we selected seven relevant studies involving 306 patients with subacute or acute Bell's palsy from PubMed, EMBASE, Web of Science, and Scopus before June 5, 2024. Low-level laser therapy (LLLT) efficacy for facial nerve paralysis was assessed in seven studies.