8,186 results match your criteria: "İstanbul University Medical Faculty[Affiliation]"

Article Synopsis
  • This study explores the outcomes and management of pediatric auditory brainstem implantation (ABI) for children with severe inner ear malformations, aiming to unify clinical practices and address current challenges.
  • A systematic review of relevant findings from the Third International Pediatric ABI Symposium analyzed data from multiple countries, highlighting trends in auditory outcomes, surgical approaches, and rehabilitation strategies.
  • Key conclusions emphasize the need for standardized guidelines and improved collaboration among healthcare professionals to enhance patient outcomes and guide future research in this specialized field.
View Article and Find Full Text PDF
Article Synopsis
  • Poikiloderma with neutropenia (PN) is a rare genetic condition resulting from mutations in a specific gene, characterized by skin changes, ongoing low neutrophil levels, and recurrent respiratory infections.
  • A case study of a 15-month-old boy revealed symptoms like skin hyperpigmentation, growth issues, and respiratory infections, with notable physical traits such as facial dysmorphism and widespread poikiloderma.
  • Laboratory tests indicated mild neutropenia and low immunoglobulin levels, leading to treatment with immunoglobulin replacement and antibiotics, highlighting the importance of monitoring immune function in patients with recurrent infections.
View Article and Find Full Text PDF

Lumbar spinal stenosis is a common degenerative condition, especially in older adults, leading to significant morbidity. Age, gender, and lumbar level variations in spinal canal width are critical in assessing stenosis risk. Many patients exhibit radiographic narrowing without clinical symptoms.

View Article and Find Full Text PDF

Retrospective analysis of hemophilia B in Turkey: identifying main characteristics and treatment options.

Res Pract Thromb Haemost

October 2024

Department of Internal Medicine, Division of Hematology, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Background: Hemophilia B (HB), an X-linked recessive inherited bleeding disorder, exhibits a high prevalence among males.

Objectives: To present the first national cohort of persons with HB to define the demographics, clinical characteristics, and treatment patterns in Turkey.

Methods: This multicenter, retrospective study included 433 alive persons with HB registered in 35 centers between 1961 and 2018.

View Article and Find Full Text PDF

The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood.

View Article and Find Full Text PDF
Article Synopsis
  • * Tension gastrothorax can mimic other serious conditions like tension pneumothorax or pleural effusion, making it challenging to diagnose correctly based on initial X-rays.
  • * Treatment involves reducing the pressure from the stomach by inserting a nasogastric catheter or, if that fails, using needle aspiration to prevent mediastinal shift, which can cause respiratory distress and cardiac complications.
View Article and Find Full Text PDF

BACKGROUND Non-occlusive mesenteric ischemia (NOMI) is difficult to diagnose and has a high mortality rate. We aimed to determine the qualitative and quantitative parameters of computed tomography (CT) that can determine patient prognosis and contribute to early diagnosis in order to reduce mortality. MATERIAL AND METHODS The biphasic CT images of 40 patients, mean age 72.

View Article and Find Full Text PDF
Article Synopsis
  • Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved outcomes for heart failure patients in the FINEARTS-HF trial but led to elevated serum potassium levels.
  • The study aimed to analyze the frequency of abnormal serum potassium levels (<3.5 mmol/L and >5.5 mmol/L) and the impact of finerenone treatment compared to placebo on patient outcomes.
  • Results showed that participants taking finerenone experienced significantly higher potassium levels over time, with increased risk of levels >5.5 mmol/L and reduced risk of levels <3.5 mmol/L, indicating a notable effect of the drug on potassium regulation.
View Article and Find Full Text PDF

Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry.

Joint Bone Spine

November 2024

Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy. Electronic address:

Article Synopsis
  • The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
  • A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
  • Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on isolated medial malleolar fractures, which are less common than other types of ankle fractures, and evaluates outcomes of treatment using cross-screw fixation.
  • Thirteen patients were treated and assessed for fracture healing after 3 months and functional recovery using the AOFAS score, showing positive results with an average score of 82 at 3 months and 92.2 at 24 months.
  • Cross-screw fixation is recommended for its benefits, including minimal soft-tissue damage and effective stabilization, making it a suitable option for these types of fractures.
View Article and Find Full Text PDF

The purpose of this study is to investigate the relationship between reported symptoms, functional outcomes, and pain coping mechanisms in participants with lower limb lymph-edema. This research has been designed as cross-sectional. Participants' age, sex, height, weight, pain, tightness, and stiffness levels reported by the participants were documented with a 10 cm visual analogue scale.

View Article and Find Full Text PDF

Introduction: Topical dapsone has a level A recommendation for the treatment of papulopustular rosacea; however, its treatment efficacy has not been studied previously. The aim of this study is to evaluate the safety and efficacy of topical 7.5% dapsone gel applied once daily at night in the treatment of papulopustular rosacea.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated a method to test for beta-lactam antibiotic (BLA) allergies in children with a history of low-risk non-immediate reactions (NIR) using a direct single therapeutic dose challenge followed by a prolonged drug provocation test (DPT).
  • A total of 109 children participated, with most reporting a reaction to amoxicillin-clavulanic acid; the most common symptom observed was maculopapular exanthema.
  • Results indicated that an initial single-dose DPT was safe and effective, with only a small percentage experiencing minor reactions, suggesting this approach can help identify true allergies in children.
View Article and Find Full Text PDF

Introduction: Medial femoral cutaneous (MFC) sensory nerve action potentials (SNAPs) can be easily recorded using distal stimulation. This study aimed to identify a new parameter using MFC SNAPs for the early electrophysiological diagnosis of length-dependent axonal polyneuropathy (LDAP) associated with uremic neuropathy.

Methods: Patients with chronic renal failure who were referred to the electrodiagnostic laboratory due to symptoms suggesting polyneuropathy were included.

View Article and Find Full Text PDF

Cardiomyopathy, which is shortly defined as a disease of the myocardium, has a broad definition that includes many different diagnoses. Recent advances in cardiac imaging techniques, including basic and advanced echocardiography, computed tomography, nuclear medicine, and cardiac magnetic resonance, allow for a more accurate evaluation of volumes and thickness of cardiac chambers, systolic and diastolic function of the ventricules, and tissue structure. Multimodality imaging often provides the first clinical suspicion for specific etiologies, especially when the medical and family history is unclear, by identification of red flags of underlying systemic diseases.

View Article and Find Full Text PDF

Objectives: Patients with liver transplant can present to a pediatric emergency department with short- and long-term complications of transplant. Here, we described clinical features of pediatric liver transplant patients admitted to the pediatric emergency department and identified risk factors that may lead to pediatric intensive care unit admission.

Materials And Methods: We retrospectively evaluated pediatric liver transplant patients admitted posttransplant to Baskent University Hospital's pediatric emergency department in 2023.

View Article and Find Full Text PDF

Objectives: Posttransplant lymphoproliferative disorder is a consequential complication following solid-organ transplant, particularly associated with the Epstein-Barr virus. We studied a single center's cases of pediatric posttransplant lymphoproliferative disorder for a 7-year period and focused on incidence rates, anatomic sites involved, and correlation with clinical outcomes. We explored clinical features and treatment outcomes in patients with pediatric posttransplant lymphoproliferative disorder, with emphasis on patient survival and associated clinical ramifications.

View Article and Find Full Text PDF
Article Synopsis
  • Pneumomediastinum is a rare condition in children characterized by the presence of air in the mediastinum, often resulting from trauma or occurring without identifiable injury.
  • A study assessed 26 patients under 18 years diagnosed with pneumomediastinum from 2011 to 2023, reviewing their clinical data and treatment approaches.
  • The causes varied, including trauma types and foreign body aspiration, with most patients managed conservatively; however, complications were noted, and those with complicated cases required longer hospital stays.
View Article and Find Full Text PDF

The effect of hereditary thrombophilia on recurrent pregnancy loss: a retrospective cohort study.

BMC Pregnancy Childbirth

November 2024

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.

Objective: Thrombophilia screening has been performed in patients with conditions such as previous fetal death, (fetal growth restriction) FGR, preeclampsia, (hemolysis. elevated liver enzyme, low platelet count) HELLP Syndrome, previous abruptio placentae, previous thrombosis in pregnancy, and abnormal placental histology. The actual role of hereditary thrombophilia in recurrent pregnancy loss (RPL) is still debated.

View Article and Find Full Text PDF

Vitamin D, allergen sensitization, and atopic dermatitis.

World Allergy Organ J

November 2024

Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya, Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye.

View Article and Find Full Text PDF