Evaluation of the Glymphatic System in Rabbits Using Gadobutrol-Enhanced MR Cisternography With T1 and T2 Mapping.

Purpose: We aimed to characterize and further understand CSF circulation and outflow of rabbits. To our knowledge, there is no research on contrast material-enhanced MR cisternography (CE-MRC) with T1 and T2 mapping in the rabbit model using a clinical 3-T MR unit without a stereotaxic frame.

Materials And Methods: Twenty-one rabbits were included in the study.

Effect of nebivolol on erectile function: a systematic review and meta-analysis of randomized controlled trials.

Background: Historically, β-blockers have been associated with erectile dysfunction (ED). Nebivolol, a third-generation β-blocker, may have had no negative effect on erectile function because of its vasodilating properties. However, the evidence level was considered either as low or very low.

Evaluation of Tridax procumbens Secondary Metabolites Anti-Tuberculosis Activity by In Vitro and In Silico Methods.

Mycobacterium tuberculosis is a human pathogen that causes Tuberculosis (TB) disease. Researchers have reported the activity of traditional medicinal plants against human pathogens. However, antimycobacterial studies of medicinal plants against M.

Trabectedin for L-Type Sarcoma: A Retrospective Multicenter Study.

(1) Background: Metastatic L-type sarcomas (liposarcoma and leiomyosarcoma) are rare and have a poor prognosis. Trabectedin is an effective agent that can be used after anthracyclines. This study was designed to evaluate the real-life effectiveness and safety of trabectedin.

Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study.

Background/objectives: Ebola virus disease (EVD) survivors develop post-acute ophthalmic sequelae, including a high prevalence of uveitis that may be complicated by vision-threatening cataract. After the non-detection of Ebola virus (EBOV) RNA in sampled ocular fluid, vision impairment due to cataract can be treated safely and effectively via manual small incision cataract surgery (MSICS). However, the long-term ocular visual outcomes and assessment of ocular tissues, including for genomic RNA, have been infrequently or not reported in Western African survivors.

Demographic and Socioeconomic Disparities in Adolescent Obesity: Insights From the National Survey of Children's Health Database.

Background:  Obesity among adolescents is a significant public health concern. This study analyzes the prevalence of obesity among adolescents using data from the National Survey of Children's Health (NSCH). The analysis focuses on the impact of race and socioeconomic variables on obesity rates.

Enablers and barriers to the implementation of breast self-examination (BSE) education programmes among adolescent girls in Sub-Saharan Africa (SSA): an integrative systematic review protocol.

Background: Breast cancer is emerging as a leading cause of mortality among women and adolescent girls in Sub-Saharan Africa (SSA). However, there is a lack of clarity on the enablers and barriers associated with the implementation of preventive strategies, such as breast self-examination (BSE), particularly among adolescent girls.

Objective: This paper presents a protocol for conducting a systematic review aiming to synthesise studies on the enablers and barriers to implementing BSE education programmes among adolescent girls in SSA.

Cutaneous leishmaniasis: a neglected clinical manifestation among the tribal population in Nilambur, Kerala, India.

Background: Different clinical manifestations of leishmaniasis (cutaneous and visceral) caused by Leishmania donovani have been reported from Kerala, India. Leishmania donovani causing cutaneous leishmaniasis (CL) (also called atypical CL [ACL]) is one of the major health concerns in the Western Ghats belt of the state.

Methods: Skin biopsies of 20 patients with suspected CL from Nilambur, Kerala, were processed for CL diagnosis during the period 2022-2023.

Comparative evaluation of platelet-rich plasma + β-tricalcium phosphate and platelet-rich fibrin + β-tricalcium phosphate for healing periapical lesions, using cone beam computed tomography - an study.

Background: Platelet concentrates are currently being researched for their potential to enhance bone formation.

Aim: The aim of this study is to quantitatively evaluate and compare bone regeneration in periapical lesions using a combination of platelet-rich plasma (PRP) + β-tricalcium phosphate (β-TCP) and platelet-rich fibrin (PRF) + β-TCP.

Methods: Ten subjects with periapical lesions measuring 10-20 mm in relation to maxillary incisors indicated for periapical surgery were selected.

Long-term physical and mental health outcomes of Ebola Virus Disease survivors in Kenema District, Sierra Leone: A cross-sectional survey.

The 2013-2016 Ebola Virus Disease (EVD) epidemic in West Africa was the deadliest in history, with over 28,000 cases. Numerous physical and mental health symptoms have been reported in EVD survivors, although there is limited prior research on how the health of survivors compares to the general population. We conducted a survey of EVD survivors in Kenema District, Sierra Leone and a population-based sample of community members who lived in EVD-affected areas but were not diagnosed with EVD, and compared resulting data about self-reported symptoms, duration, and severity between EVD survivors and community members through multivariate regression models.

Organisms Causing Postoperative Implant Infection in Orthopedic Patients Presenting at a Tertiary Care Hospital.

Introduction Infections pose a significant challenge in orthopedics related to implant failure. In orthopedic surgeries, surgical site infections (SSIs) extend the patient's hospital stay by an average of two weeks and also increase morbidity, double hospitalization rates, and triple the financial burden on the patient. This study aims to determine the common organism in patients with postoperative implant infections presenting at a tertiary care hospital.

An advocacy based cross sectional study of healthcare professionals of factors impacting on medication adherence across nine Sub-Saharan African countries.

Background: Adherence to anti-seizure medication (ASM) by people diagnosed with epilepsy in sub-Saharan Africa remains low. The factors for low adherence are not well understood. To improve adherence, it is important to understand the perceptions and views of healthcare professionals delivering epilepsy care to this population.

Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area.

Pre-clinical and clinical evidence proposes that creatine monohydrate, an affordable nutraceutical, could be a useful adjunct to conventional antidepressant treatments. In this pilot feasibility and exploratory study, we investigate the 8-week effects of creatine in addition to cognitive-behavioural therapy (CBT) versus placebo plus CBT in depression. For the primary efficacy outcome of change in Patient Health Questionnaire-9 depression score at study endpoint, we used mixed-model repeated measures analysis of covariance.

Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana.

Background: Prescribers must possess extensive knowledge and maintain a positive attitude towards the rational use of medicines to achieve desirable treatment outcomes and effectively prevent treatment failures, increased costs, drug toxicities, and interactions. The objective of this study was to evaluate prescribers' understanding and perception concerning the rational use of medicines in public hospitals. Additionally, the study aimed to identify the factors that influence rational prescribing practices.

Nutritional Supplementation in Tuberculosis Treatment: A Mixed Methods Study of Clinical Outcomes and Patient Perceptions in Jamnagar, India.

Background: Tuberculosis (TB) remains a significant global health challenge, with malnutrition being a key risk factor for poor outcomes. This study aimed to evaluate the impact of nutritional supplementation on treatment outcomes in drug-sensitive pulmonary tuberculosis (DS-PTB) patients and explore patient perspectives on nutrition during TB treatment.

Methods: We conducted a mixed methods study in the Jamnagar district of Gujarat, India.

Inter-atrial Septum Stenting in Congenital Heart Disease Patient: A Case Series in Indonesia.

Background: Inter-atrial septum (IAS) stenting in duct-dependent congenital heart disease patient has shown to be an effective way to maintain inter-atrial blood flow, however it is still considered a high risk procedure and inter-atrial septum stenting remains a low-frequency procedure.

Method: A single-center observational cohort study was carried out at the National Cardiovascular Center Harapan Kita (NCCHK) between April 2019 and April 2023. This study included duct-dependent congenital heart disease patients.

Cervical Cancer Prevention Among Rural Women in Gujarat, India: A Mixed Methods Study on Risk Factors and KAP (Knowledge, Attitude and Practice).

Background: Cervical cancer causes significant morbidity and mortality among women in India. Despite national screening guidelines, uptake of these tools remains poor, especially in rural areas where complex sociocultural factors are at play. Integrated mixed-methods designs can provide better insights into multilevel barriers influencing screening behaviours.