Central residues of FSHβ (89-97) peptide are not critical for FSHR binding: Implications for peptidomimetic design.

In our previous study, we had identified a 9-mer peptide (FSHβ (89-97)) derived from seat belt loop of human FSHβ and demonstrated its ability to function as FSHR antagonist in vivo. Structure analysis revealed that the four central residues STDC within this peptide may not be critical for receptor binding. In the present study, STDC residues were substituted with alanine to generate ΔFSHβ 89-97(STDC/AAAA) peptide.