32,220 results match your criteria: "§University of Maryland School of Medicine[Affiliation]"
A novel cortical biomarker signature predicts individual pain sensitivity.
medRxiv
November 2024
Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, USA.
Article Synopsis
- - The study aimed to validate a biomarker signature for chronic pain management, using measures called peak alpha frequency (PAF) and corticomotor excitability (CME), in a model induced by nerve growth factor injections in the jaw muscle.
- - A total of 150 participants experienced pain for up to 4 weeks post-injection, with EEG and TMS used to assess PAF and CME; machine learning models were developed to predict pain sensitivity based on these measures.
- - The analysis showed that logistic regression was extremely effective, achieving perfect classification in training and strong performance in testing, indicating the PAF/CME biomarker signature has great promise for clinical applications in pain assessment.
? TFEB promotes virus replication before being cleaved by a viral protease.
Autophagy Rep
September 2024
Department of Microbiology and Immunology and Center for Pathogen Research, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA.
Opioid-induced Esophageal Dysfunction Masquerading as Type I Achalasia.
J Neurogastroenterol Motil
October 2024
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Early human milk feeding: Relationship to intestinal barrier maturation and postnatal growth.
Pediatr Res
October 2024
Department of Pediatrics, University of Maryland School of Medicine, 22 S, Greene St, Baltimore, Maryland, 21201, USA.
Article Synopsis
- Early exposure to mother's own milk (MOM) in preterm infants aids in developing a better intestinal barrier, and the study hypothesizes that donor human milk (DHM) can have similar effects on intestinal permeability (IP).
- The research involved 158 preterm infants, measuring IP via a sugar absorption test and assessing nutritional data; they found that diets with exclusive MOM or DHM led to lower IP compared to preterm formula.
- Results indicate that a higher intake of MOM or DHM in the first 7-10 days post-birth fosters intestinal maturation, but this low IP does not correlate with reduced postnatal growth failure by the time of discharge.
Peripheral Nerve Stimulation for Pain Management: A Survey of Clinical Practice Patterns.
Neuromodulation
February 2025
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- Clinical interest in peripheral nerve stimulation (PNS) has grown due to its potential benefits for chronic pain management over traditional medications, but variability in its use persists due to the lack of clear guidelines and standardized systems.
- A survey of 94 pain physicians revealed that PNS is most commonly used for neuropathic pain conditions, such as peripheral neuralgia, while its application for nociceptive pain like chronic low back pain and osteoarthritis shows mixed results.
- The study highlights the common practice of conducting nerve blocks prior to PNS for anatomical verification, with practitioners seeking a minimum 50% to 75% pain relief as a requirement to proceed with treatment.
Rare CCND2 (p.Thr280Ile) Variant Associated With Infantile Spasms in a Patient With Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome.
Pediatr Neurol
December 2024
Department of Pediatrics and Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address:
Article Synopsis
- - This report details a pediatric case of MPPH syndrome, a rare neurodevelopmental disorder linked to gene variants, specifically a unique CCND2 variant in this patient that caused serious neurological issues.
- - The patient showed significant prenatal abnormalities, such as ventriculomegaly and polymicrogyria, and developed infantile spasms which were eventually managed with topiramate after prednisone failed.
- - The findings emphasize the need for prompt genetic testing and neuroimaging for accurate diagnosis and management of MPPH syndrome, suggesting that early intervention could lead to better developmental outcomes.
Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study.
J Comp Neurol
October 2024
Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland, USA.
Article Synopsis
- Researchers used an advanced technique called RNAScope to measure the levels of three dopamine receptors (Drd1, Drd2, Drd3) in specific brain regions related to song control in male and female canaries, who were treated with testosterone to promote singing activity.
- The study found that all receptor types were present in the various regions, except Drd3 in Area X, but there were very few noticeable differences between male and female canaries regarding dopamine receptor expression, which did not account for the differences in song.
- The majority of dopamine receptor-expressing cells in the HVC area were linked to excitatory markers, while the PAG had lower receptor density and fewer inhibitory cells, and activation of these cells during
HDAC7 promotes cardiomyocyte proliferation by suppressing Myocyte Enhancer Factor 2.
J Mol Cell Biol
October 2024
Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Postnatal mammalian cardiomyocytes (CMs) rapidly lose proliferative capacity and exit the cell cycle and undergo further differentiation and maturation. Cell cycle activation has been a major strategy to stimulate postnatal CM proliferation, albeit achieving modest effects. One impediment is that postnatal CMs may need to undergo dedifferentiation before proliferation, if not simultaneously.
View Article and Find Full Text PDFSomatic mutations in autoinflammatory and autoimmune disease.
Nat Rev Rheumatol
November 2024
Center for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY, USA.
Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to malignant processes but over the past decade have been increasingly causally connected to benign diseases including rheumatic conditions. Here we outline the contribution of somatic mutations to complex and monogenic immunological diseases with a detailed review of unique aspects associated with such causes.
View Article and Find Full Text PDFLong-term retreatment outcomes after definitive management of Graves' disease with radioactive iodine versus surgery.
Surgery
January 2025
Department of Surgery, University of Maryland Medical Center, Baltimore, MD. Electronic address:
Article Synopsis
- This study compared the long-term outcomes of treating Graves' disease with surgery versus radioactive iodine (RAI).
- It found that patients treated with surgery had a much higher rate of remission at 6 months (98.6%) compared to those treated with RAI (68.8%).
- Patients who received RAI also had a higher chance of needing additional treatments later, while those who underwent surgery had lower retreatment rates overall.
Article Synopsis
- Adolphe Quetelet's 1835 work provided a mathematical analysis showing that body weight is approximately proportional to height in adults, a concept that later evolved into what we now call body mass index (BMI).
- BMI has become a global standard for assessing body fatness at both individual and population levels, evolving through extensive scientific discourse.
- The rise of effective weight loss treatments has sparked renewed examination of BMI's origins and its appropriateness for diagnosing obesity, emphasizing the importance of understanding its historical and mathematical basis for students and practitioners in health fields.
Macro- and Microstructural White Matter Differences in Neurologic Postacute Sequelae of SARS-CoV-2 Infection.
AJNR Am J Neuroradiol
December 2024
From the Department of Diagnostic Radiology & Nuclear Medicine (E.E.O., N.R., T.A.Z.), University of Maryland School of Medicine, Baltimore, Maryland.
Article Synopsis
- - Neuropsychiatric complications from SARS-CoV-2, termed NeuroPASC, impact 10%-60% of those infected, leading to cognitive challenges linked to white matter (WM) involvement in the brain.
- - A study with 72 participants revealed that those with NeuroPASC had larger cerebral WM volumes and exhibited signs of ongoing neuroinflammation, as shown by higher WM mean kurtosis and more self-reported symptoms like headaches.
- - Participants with NeuroPASC demonstrated poorer performance in cognitive functions such as attention and memory retrieval compared to asymptomatic controls, suggesting significant cognitive and immune system differences between the groups.
Sensory loss rehabilitation among people with dementia: a low-risk strategy to enhance quality of life.
Lancet Healthy Longev
November 2024
Optimal Aging Institute, NYU Grossman School of Medicine, NY, USA.
Characteristics and outcomes of children 2-23 months of age with prolonged diarrhoea: A secondary analysis of data from the 'Antibiotics for Children with Diarrhea' trial.
J Glob Health
October 2024
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Article Synopsis
- About 12% of diarrhoeal cases last 7-13 days, termed prolonged diarrhoea, which is linked to the majority of diarrhoeal deaths in young children.
- The study evaluated young children (2-23 months) with acute (<7 days) and prolonged (≥7-13 days) diarrhoea using data from a large trial conducted across seven countries in Asia and sub-Saharan Africa between 2017 and 2019.
- Findings showed that prolonged diarrhoea was associated with factors like younger age, larger family size, maternal illiteracy, moderate underweight, and the presence of certain pathogens, with significant implications for children's health outcomes at a 90-day follow-up.
Changes in use of multiplex respiratory panel testing during the COVID-19 pandemic.
Infect Control Hosp Epidemiol
October 2024
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Background: COVID-19 changed the epidemiology of community-acquired respiratory viruses. We explored patterns of respiratory viral testing to understand which tests are most clinically useful in the postpandemic era.
Methods: We conducted a retrospective observational study of discharge data from PINC-AI (formerly Premier), a large administrative database.
Emergency physicians perspectives of state continuing medical education requirements for medical licensure.
J Am Coll Emerg Physicians Open
October 2024
American Board of Emergency Medicine East Lansing Michigan USA.
Objectives: This study aims to better understand the perspectives of emergency medicine physicians' on the role that state-mandated, topic-specific continuing medical education (CME) plays in addressing knowledge gaps, its relevance to current emergency practice, its reported burden and costs of CME activities to emergency physicians, and its perceived improvement in patient care.
Methods: A cross-sectional survey was designed by the Coalition of Board-Certified Emergency Physicians (COBCEP) and distributed in February 2023 to all American Board of Emergency Medicine (ABEM)-certified physicians. Statistical tests of significance (Pearson's chi-square and Fisher's exact test) assessed the cost and time spent on CME as well as the perceived value placed on CME by ABEM-certified physicians to improve patient care.
Increase in Cases of Perinatal HIV Transmission in Maryland in 2022.
Pediatrics
November 2024
Departments of Pediatrics.
The perinatal transmission of HIV is preventable through a regimen that includes testing of all pregnant individuals, antiretroviral treatment (ART) for the pregnant individual, prophylactic or preventative ART for the infant, and cesarean section delivery for mothers with HIV viremia at the time of delivery. Under this protocol, the United States has seen a significant decline in the perinatal transmission of HIV and achieved a perinatal HIV transmission rate of 0.9% in 2019.
View Article and Find Full Text PDFRare variant contribution to the heritability of coronary artery disease.
Nat Commun
October 2024
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Article Synopsis
- Whole genome sequencing (WGS) helps identify rare genetic variants that may explain the missing heritability of coronary artery disease (CAD) by analyzing 4,949 cases and 17,494 controls from the NHLBI TOPMed program.
- The study estimates that the heritability of CAD is around 34.3%, with ultra-rare variants contributing about 50%, especially those with low linkage disequilibrium.
- Functional annotations show significant enrichment of CAD heritability, highlighting the importance of ultra-rare variants and specific regulatory mechanisms in different cells as major factors influencing genetic risk for the disease.
Dual Energy CT for Deep Learning-Based Segmentation and Volumetric Estimation of Early Ischemic Infarcts.
J Imaging Inform Med
October 2024
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Article Synopsis
- Ischemic changes in the brain are hard to detect on regular head CT scans for several hours after an infarct, but deep learning models may help identify these changes using advanced imaging techniques.
- This study evaluates the use of dual-energy CT (DECT) to enhance early visibility of brain infarcts for machine learning applications, using a dataset of 330 DECTs collected within 48 hours of confirming an infarct via MRI.
- Results showed that combining images from both standard 120 kV and 190 keV DECT significantly improved the algorithm's performance in accurately segmenting brain infarcts, especially notable within 6 to 12 hours after the last known well time.
Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis.
Aging Cell
October 2024
Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Article Synopsis
- * Studies show that the loss of the Men1 protein in osteoblasts leads to structural bone changes similar to those observed in osteoporosis patients, characterized by decreased bone-forming and increased bone-resorbing activities.
- * The research suggests that loss of Men1 triggers cellular senescence via mTORC1 activation and AMPK suppression, with potential treatment benefits from metformin, indicating a new avenue for therapeutic strategies against age-related osteoporosis.
The influence of the American Association for Thoracic Surgery on clinical trial development by cardiothoracic surgeons.
J Thorac Cardiovasc Surg
October 2024
Division of Cardiac Surgery, Department of Cardiovascular and Thoracic Surgery, West Virginia University School of Medicine, Morgantown, WVa. Electronic address:
Objective: Clinical trials play a critical role in the rapidly evolving field of cardiothoracic surgery and the American Association for Thoracic Surgery Clinical Trials Methods Course has provided a biannual symposium led by preeminent surgeons with vast experience in planning, conducting, and analyzing surgical clinical trials. This study hypothesizes that participation in the course is associated with future success in clinical trial leadership.
Methods: A list of course attendees (2014-2022) was queried in ClinicalTrials.
The Untapped Potential of Tax Data in Health Research.
JAMA Surg
December 2024
Center for Orthopaedics, Injury, and Research Innovation, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore.
Tactics versus Strategy in Trauma Resuscitation.
Anesthesiology
November 2024
US Anesthesia Partners, Columbia, Maryland; Department of Anesthesiology, University of Maryland School of Medicine, Fulton, Maryland.
Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond.
Front Oncol
September 2024
Division of Neurosurgery, Chair Emeritus, Hospital for Sick Children, Toronto, ON, Canada.
Article Synopsis
- Brain surgeons need standardized rules for handling brain tumors during surgery to improve diagnosis and treatment.*
- Right now, guidelines mainly exist for one type of brain tumor, but others could also benefit from these rules.*
- Having experts from different fields work together is important for creating these standardized practices to help patients and research better.*