CHARTING THE EVOLUTION AND TRANSFORMATIVE IMPACT OF THE PACIFIC SYMPOSIUM ON BIOCOMPUTING THROUGH A 30-YEAR RETROSPECTIVE ANALYSIS OF COLLABORATIVE NETWORKS AND THEMES USING MODERN COMPUTATIONAL TOOLS.

Founded nearly 30 years ago, the Pacific Symposium on Biocomputing (PSB) has continually promoted collaborative research in computational biology, annually highlighting emergent themes that reflect the expanding interdisciplinary nature of the field. This study aimed to explore the collaborative and thematic dynamics at PSB using topic modeling and network analysis methods. We identified 14 central topics that have characterized the discourse at PSB over the past three decades.

A Simple Morphometric Analysis of Preoperative Therapy Response for Esophageal Adenocarcinoma.

Context.—: Histologic assessment of tumor regression grade (TRG) on esophagogastrectomy specimens after neoadjuvant therapy is an excellent predictor of local recurrence rate and long-term survival in esophageal adenocarcinomas. Although several grading systems exist globally, the modified Ryan system suggested by the College of American Pathologists (CAP) is widely used in North America.

Refugees' Human and Social Capital and Health Insurance Coverage.

The lack of health insurance coverage is one of the most serious challenges confronting refugees and an important public policy issue. This study examines how refugees' human and social capital is linked to their health insurance coverage. This study uses the 2020 Annual Survey of Refugees public use data file to test the relationship between refugees' human and social capital and their health insurance coverage.

Outcomes of A2/A2B to B Deceased Donor Kidney Transplantation: A Retrospective Study.

Background A2/A2B to B kidney transplantation has the potential to increase transplant access for traditionally disadvantaged blood group B minority candidates. Despite prior reports of positive post-transplant safety and clinical success, A2/A2B to B kidney transplantation remains underutilized in the United States. This study aims to investigate the post-transplant outcomes of A2/A2B to B kidney transplants performed at our center.

SIOOT recommendations for the optimal application of the oxygen-ozone therapy in clinical medicine.

Oxygen-ozone therapy has garnered increasing attention for its potential therapeutic applications, yet its widespread adoption is hindered by inconsistent protocols and a lack of standardized guidelines. Standardizing these protocols is essential to ensure the safety, efficacy, and reproducibility of treatments. Advanced training for physicians and caregivers is paramount, equipping them with evidence-based knowledge and practical expertise to administer this therapy effectively while avoiding unverified or misleading innovative approaches.

From Tradition to Technology: Robotic Artificial Intelligence in Dental Implantology.

Dynamic navigation and haptic robotic systems are revolutionizing dentistry by significantly improving implant placement precision, especially in the maxillofacial region where safeguarding nerves, vessels, and vital structures is crucial. This article examines the impact of X-Guide dynamic navigation and Yomi robotics on implant surgery outcomes, comparing these technologies to traditional freehand methods. The X-Guide dynamic navigation system and Yomi robotics have both been proven to enhance accuracy, with both achieving mean deviations of around 1 mm from pre-planned positions.

Novel Schiff Base Sulfonate Derivatives as Carbonic Anhydrase and Acetylcholinesterase Inhibitors: Synthesis, Biological Activity, and Molecular Docking Insights.

Sulfonate derivatives are an essential class of compounds with diverse pharmacological applications. This study presents the synthesis and detailed characterization of six novel Schiff base sulfonate derivatives (L-L) through spectroscopic techniques (FT-IR and NMR). Their inhibitory potential was evaluated against human carbonic anhydrase isoenzymes (hCA I and hCA II) and acetylcholinesterase (AChE), which are crucial therapeutic targets for diseases such as glaucoma, epilepsy, and Alzheimer's disease.

Bioactivity of fluorophenyl thiourea derivatives: Antioxidant efficacy and inhibition of key diabetes-related enzymes.

Thiourea structures, known for their wide-ranging bioactivity, have significant potential in diabetes management. In this study, it was aimed to examine the antioxidant capacities of fluorophenyl thiourea derivative compounds and their inhibition studies on α-amylase and α-glycosidase enzyme activity. Antioxidant capacity was determined using Fe-Fe, FRAP, and Cu-Cu reducing analyses, DPPH· and ABTS· scavenging experiments.

Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.

Introduction: Antisense oligonucleotide (ASO) was established as a viable therapeutic option for genetic disorders. ASOs can target RNAs implicated in various diseases, including upregulated mRNA and pre-mRNA undergoing abnormal alternative splicing events. Therapeutic applications of ASOs have been proven with the Food and Drug Administration approval of several drugs in recent years.

Biodegradation and mechanical performance of Silane-chitosan-graphene oxide composite coating on AZ31 magnesium alloys for biomedical applications.

Biodegradable magnesium alloy medical implants have attracted considerable interest thanks to their remarkable biocompatibility and mechanical properties. However, the rapid corrosion rate of magnesium alloys in physiological environments presents a major challenge to their practical application. Therefore, this study attempted to design a silane/chitosan /graphene oxide composite coating that reduces the corrosion and enhances the biodegradation of magnesium alloys used in temporary implants.

Variation of bacterial community diversity and composition in saline-alkali soils reclaimed with flood irrigation and crop cultivation is driven by salinity and edaphic factors.

Reclamation is crucial for improving the fertility and productivity of saline-alkali soils, but the evolution of soil bacterial communities during the course of reclamation, which is an important feedback of soil micro-ecosystem, has received little attention. This study was conducted to investigate the variation of bacterial community diversity and composition in reclaimed saline-alkali soils based on space-for-time substitution, elucidate the underlying ecological mechanisms of bacterial community assembly processes, and identify the key driving factors of bacterial community evolution. The soil bacterial communities in undeveloped saline-alkali land and farmlands with different reclamation history (1-4, 5-6, and 10-25 years) in the Yellow River Delta, China, was analyzed by 16S rRNA gene amplicon sequencing.

The impact of global change factors on the functional genes of soil nitrogen and methane cycles in grassland ecosystems: a meta-analysis.

Soil functional genes in grasslands are crucial for processes like nitrogen fixation, nitrification, denitrification, methane production, and oxidation, integral to nitrogen and methane cycles. However, the impact of global changes on these genes is not well understood. We reviewed 84 studies to examine the effects of nitrogen addition (N), warming (W), increased precipitation (PPT +), decreased precipitation (PPT-), and elevated CO (eCO) on these functional genes.

Expression of ALG8 in hepatocellular carcinoma and its diagnostic and prognostic significance.

Background: Alpha-1,3-glucosyltransferase (ALG8), a key enzyme in protein glycosylation, is implicated in the oncogenesis and progression of several human malignancies. This study aimed to define the role of ALG8 in hepatocellular carcinoma (HCC) and uncover its mechanisms of action.

Methods: ALG8 expression in HCC and normal tissues was analyzed using the TCGA and GEO databases, validated by RT-qPCR and western blot.

Rosavin derived from Rhodiola alleviates colitis in mice through modulation of Th17 differentiation.

Background: Rosavin (RSV) is a naturally occurring compound isolated from Rhodiola species. While RSV has been reported with pharmacological activities of anti-oxidation, anti-inflammation, anti-stress and immunomodulation, its effect on colitis and the underlying mechanisms remain unclear.

Purpose: This study aims to investigate whether and how RSV alleviated colitis in mice.

New species of the plant bug genus Neolygus Knight from Japan, Taiwan and Thailand (Hemiptera: Heteroptera: Miridae: Mirini).

Ten new species of the Holarctic-Oriental mirine genus Neolygus Knight are documented, on the basis of specimens collected from eastern Asia and the Oriental Region: N. autumnus n. sp.

A novel approach to enhancing biomedical signal recognition via hybrid high-order information bottleneck driven spiking neural networks.

Biomedical signals, encapsulating vital physiological information, are pivotal in elucidating human traits and conditions, serving as a cornerstone for advancing human-machine interfaces. Nonetheless, the fidelity of biomedical signal interpretation is frequently compromised by pervasive noise sources such as skin, motion, and equipment interference, posing formidable challenges to precision recognition tasks. Concurrently, the burgeoning adoption of intelligent wearable devices illuminates a societal shift towards enhancing life and work through technological integration.

A Multifunctional Tb(III)-Based Metal-Organic Framework for Chemical Conversion of CO, Fluorescence Sensing of Trace Water and Metamitron.

The utilization of metal-organic frameworks (MOFs) as fluorescent sensors for the detection of environmental and chemical reagent pollutants as well as heterogeneous catalysis for CO conversion represents a crucial avenue of research with significant implications for the protection of human health. In this work, a Tb(III)-based three-dimensional metal-organic framework, [Tb(L)·4DMF] (Tb-MOF) (HL = 5'-(4-carboxy-3-hydroxyphenyl)-3,3″-dihydroxy-[1,1':3',1″-terphenyl]-4,4″-dicarboxylic acid), has been structurally conformed by single-crystal X-ray crystallography. It possesses a 1D rhombus channel along the [010] direction, featuring a pore size of 6.

Symptom clusters and network analysis in patients with gynecologic cancer undergoing chemotherapy: A cross-sectional study.

Objective: This study aimed to explore the complex relationships among symptoms and symptom clusters in patients with gynecologic cancer receiving chemotherapy using symptom network analysis, and to identify core symptoms and core symptom clusters.

Methods: A cross-sectional study was conducted at the Affiliated Hospital of Jiangnan University from December 2023 to June 2024, including 221 patients with gynecologic tumors. Participants completed demographic and clinical information questionnaires and the Chinese version of the MD Anderson Symptom Inventory (MDASI-C).

Alzheimer's disease-like pathology induced by in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis.

Background: () has been found to enter the brain and induce inflammation, contributing to Alzheimer's disease (AD). is also closely linked to gut dysbiosis. However, does induce AD-like pathology through the microbiota-gut-brain axis? There is limited literature on this topic.