6PPD induces cerebrovascular defects by triggering oxidative stress and ferroptosis in zebrafish.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), which is widely used as an antiozonant in rubber tires, has recently got much attention for its acute aquatic toxicity. However, the developmental toxicity of 6PPD in cerebrovascular network remains unknown. Here, we investigated the effects of 6PPD exposure in cerebral vascular using zebrafish.

Schisandrin a Ameliorates Cardiac Injury and Dysfunction Induced by Hemorrhagic Shock via Activating the Nrf2 Signaling Pathway.

Hemorrhagic shock (HS) is a critical condition with high mortality caused by acute blood loss. Cardiac injury and dysfunction induced by HS is a major factor associated with the poor prognosis of affected patients. Schisandrin A (Sch A), a dibenzocyclooctadiene lignan extracted from , exhibits multiple biological activities, including anti-inflammatory, and antioxidant effects.

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer.

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patients with untreated, histologically confirmed colorectal adenocarcinoma and no prior systemic therapy for metastatic disease were enrolled. Patients received SHR-1701 (30 mg/kg), bevacizumab (7.

Identification and subcellular localization of proteins that interact with Duck plague virus pUL14 in infected host cells.

Duck plague (DP), which is caused by duck plague virus (DPV), is an infectious disease that severely harms the waterfowl breeding industry. The UL14 protein (pUL14) is a tegument protein encoded by the UL14 gene, which is located in the unique long (UL) region of the DPV genome. DPV pUL14 plays a crucial role in viral replication, likely by interacting with host and viral proteins that have yet to be identified.

AKH/AKHR signalling system induced antioxidant response mediated by entomopathogenic fungi in Nilaparvata lugens (Stål).

The brown planthopper Nilaparvata lugens is one of the most economically important rice crop pests in Asia. Entomopathogenic fungi (EPF) have been developed as a biological control of N. lugens.

The relationship between acrylamide and neurodegenerative diseases: gut microbiota as a new intermediate cue.

Acrylamide (AA), a compound formed during the thermal processing of high-carbohydrate foods, has been implicated in the onset and progression of neurodegenerative diseases. An increasing number of reports support that gut microbiota plays a significant role in brain function and diseases, suggesting it may act as a mediator between AA exposure and the development of neurodegenerative diseases. Available studies have shown that AA intake affects the composition of the gut microbiota and the integrity of the intestinal barrier, both of which are often thought to be associated with the pathogenesis of neurodegenerative diseases, given the numerous evidences linking gut microbiota with the brain.

Molecular characterization of a novel victorivirus isolated from Stagonosporopsis citrulli.

Members of the fungal genus Stagonosporopsis are important plant pathogens that can cause severe disease on a wide range of economically important plants and crops. Here, a novel victorivirus, tentatively named "Stagonosporopsis citrulli victorivirus 1" (SciVV1), was isolated from S. citrulli isolate HS2-8.

5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis.

Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role in sorafenib resistance in hepatocellular carcinoma (HCC), and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a dysregulated lncRNA in sorafenib-resistant HCC cells. However, the underlying regulatory mechanisms of MALAT1 in sorafenib-resistant HCC cells remain unclear. In the present study, we demonstrated that 5-methylcytosine (mC) methylation catalyzed by NSUN2 and ALYREF contributed to the RNA stability and upregulation of MALAT1.

The Cathode-Electrolyte Interface Constructed with Antioxidant Ascorbic Acid Guides LNMO to Achieve Stable Cycling Under High Voltage Conditions.

LiNiMnO (LNMO) is considered one of the most promising cathode materials for high-energy-density lithium-ion batteries (LIBs). However, free-radical-induced carbonate electrolyte decomposition is a key factor hindering the improvement of battery stability. Inspired by the antioxidative properties of ascorbic acid (AA) in scavenging free radicals, the addition of AA during the electrode fabrication process can effectively terminate free radical chain reactions within the cycling of LNMO.

A general synthesis method for small-size and water-soluble NaYF:Yb, Ln upconversion nanoparticles at high temperature.

In this work, we developed a general synthesis method for the water-soluble lanthanide ion-doped NaYF upconversion (UC) nanoparticles (NPs) using triethylene glycol (TEG) as a high temperature solvent and diacid as a surfactant. Since the boiling point of the TEG is as high as 289.4 °C, the synthesis temperature can be correspondingly increased to a higher temperature that is a bit lower than this one.

A carboxymethyl chitosan and dextran hydrogel with slow and rapid photothermal conversion for sequential promoting burn wound healing and inhibiting scar proliferation.

Facilitating swift burn wound healing while effectively preventing scar formation continues to be a considerable challenge in medical practice. In this study, an injectable carboxymethyl chitosan/oxidized dextran/polyvinylpyrrolidone/dopamine (COPD) hydrogel was designed for the effective sequentially promotion of burn wound healing and inhibition of scar formation. The COPD hydrogel precursor solution was injected into the burn wound via a double-barreled syringe and transformed into an adherent hydrogel within 25 s.

New insights into rice starch-gallic acid-whey protein isolate interactions: Effects of multiscale structural evolution and enzyme activity on starch digestibility.

In starch-based food where proteins and polyphenols coexist, the impact of protein on the inhibition of starch digestion by polyphenols is unclear. Therefore, the aim of this study was to investigate the impact of whey protein isolate (WPI) on the inhibition of rice starch digestion by gallic acid (GA) from the aspects of multiscale structure and enzyme activity. Rice starch-gallic acid-whey protein isolate complex (RS-GA-WPI) was formed predominantly by hydrogen bonding and hydrophobic interactions.

Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns.

Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats.

Integrating network pharmacology and animal experimental validation to investigate the mechanism of lotus leaf in obesity.

Background: Lotus leaf and its extracts have been reported to exert various beneficial effects; however, their anti-obesity mechanisms remain relatively unclear. Therefore, we investigated the mechanism by which lotus leaf regulates obesity using network pharmacology, molecular docking, and animal experimentation.

Methods: Network pharmacology was used to identify potential targets and pathways through which lotus leaf regulates obesity.

Evaluation of resistance to Verticillium wilt in Gossypium hirsutum-Gossypium arboreum introgression lines and identification of putative resistance genes using RNA-seq.

Verticillium wilt (VW), a fungal disease caused by Verticillium dahliae (Vd), is one of the most destructive threats to cotton production. Moreover, widely cultivated upland cotton (Gossypium hirsutum, 2n = 4x = AADD = 52) often demonstrates low resistance to Vd. In contrast, G.

Reinforced enzyme mineralized chitosan hydrogels with superior mechanical and osteogenic properties.

As a natural cationic polymer material, the application of chitosan hydrogel for bone tissue engineering has been greatly limited due to its poor mechanical strength. Enzymatic mineralization has drawn increased attention to effectively improve the mechanical properties of hydrogels. In this study, carboxymethyl chitosan (CMCS) hydrogels cross-linked with different concentrations of genipin (2.

Application of a Near-Infrared Fluorescence Probe Based on Perylene Bisimide in the Detection of Heparin.

Heparin is widely used to treat thrombosis because it is an effective anticoagulant. However, excessive use of heparin can lead to an increased risk of bleeding, which makes the quantitative detection of heparin very important. An amphiphilic perylene bisimide molecule (denoted PBI-9) was developed, which presented a near-infrared emission peak at 730 nm when it was aggregated.

Intranasal oxytocin alleviates postsurgical pain and comorbid anxiety in mice: Participation of BK(Ca) channels in the hippocampus.

The affective dimension in postsurgical pain is still poorly understood. Since neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of pain and negative emotion, we investigated the potential therapeutic effect of intranasal OXT on postsurgical pain and associated anxiety in a mice model of plantar incision. The role of large conductance Ca(2+)-activated K(+) (BK(Ca)) channels was explored by using behavioral pharmacology experiments.

High Catalytic Selectivity of Electron/Proton Dual-Conductive Sulfonated Polyaniline Micropore Encased IrO Electrocatalyst by Screening Effect for Oxygen Evolution of Seawater Electrolysis.

Acidic seawater electrolysis offers significant advantages in high efficiency and sustainable hydrogen production. However, in situ electrolysis of acidic seawater remains a challenge. Herein, a stable and efficient catalyst (SPTTPAB/IrO) is developed by coating iridium oxide (IrO) with a microporous conjugated organic framework functionalized with sulfonate groups (-SOH) to tackle these challenges.

Co-In Bimetallic Hydroxide Nanosheet Arrays With Coexisting Hydroxyl and Metal Vacancies Anchored on Rod-Like MOF Template for Enhanced Photocatalytic CO Reduction.

Layered double hydroxides (LDHs) can serves as catalysts for CO photocatalytic reduction (COPR). However, the conventionally synthesized LDHs undergo undesired aggregation, which results in an insufficient number of active sites and limits the desirable electron transfer required for COPR. The metal-organic framework (MOF) template-grown LDHs demonstrate excellent promise for exploiting the strengths of both MOFs and LDHs.

Chitooligosaccharide-modified PLGA-loaded PPD nanoparticles ameliorated sepsis-associated acute kidney injury the NF-κB signaling pathway.

Objectives: Sepsis-associated acute kidney injury (SA-AKI) is a significant clinical challenge with high morbidity and mortality. Low bioavailability of protopanaxadiol (PPD) limits its clinical application. In this study, PPD was encapsulated with chitooligosaccharide (COS) modified polylactic-co-glycolic acid (PLGA) to develop novel nanomedicines for the treatment of SA-AKI.

3D Assessment of Mandibular Margin Morphological Change after BTX-A Injection for Masseter Hypertrophy: A Retrospective Study.

Background: Some facial morphological changes may occur in some patients after botulinum toxin A (BTX-A) injection for the treatment of masseteric hypertrophy. The aim of this study was to investigate the morphological changes that occurred on mandibular margin.

Methods: This retrospective analysis included 43 patients (86 lateral cases) who received BTX-A injections for masseter hypertrophy.

Homocysteine affects macrophage polarization by altering m6A methylation of scavenger receptors CD209 and CD163L1.

Atherosclerosis is a chronic inflammatory disease characterized by fatty plaque deposits on artery walls. Elevated plasma homocysteine (Hcy) levels are an independent risk factor for atherosclerosis. Research on the mechanism by which Hcy promotes atherosclerosis has gradually turned to epigenetic inheritance, but the correlation between Hcy and m6A (N6-methyladenosine) modification has not been reported.