Interfacial Assembly of Peptide Carbon Dot Hybrids Enables Photoinduced Electron Transfer with Improved Photoresponse.

Assemblies at the interface represent a powerful tool for integrating organic and inorganic components into hybrid nanostructures. Carbon dots are both excellent electron donors and acceptors, offering opportunities for their potential uses in light-harvesting applications. To further improve their functions, integration of acceptor carbon dots into donor organic nanostructures is of great interest for improving photophysical properties useful for photoinduced electron transfer.

Quantum DFT analysis and molecular docking investigation of various potential breast cancer drugs.

Breast cancer is among the deadliest cancers worldwide, highlighting the urgent need for effective treatments. This study employs density functional theory (DFT) and molecular docking analyses to evaluate the anti-cancer efficacy and specificity of drug molecules lapatinib, tucatinib, neratinib, anastrozole, and letrozole. DFT analysis provides comprehensive insights into the structural, electronic, optical, and vibrational properties of these drugs, helping to elucidate their molecular stability and reactivity through global reactivity descriptors.

Rotator Cuff Repair by All-Arthroscopic Versus Mini-Open Technique: A Comparison of Clinical and Functional Outcome.

Background: Rotator cuff tears can lead to debilitating shoulder function and impairment. Rotator cuff repair aims to eliminate pain and improve function with increased shoulder strength and range of motion. This study evaluated the differences between all-arthroscopic (AA) and mini-open (MO) repair procedures for rotator cuff tendon tears regarding clinical and functional outcomes.

Gut microbes of a high-value marine fish, Snubnose Pompano (Trachinotus blochii) are resilient to therapeutic dosing of oxytetracycline.

Trachinotus blochii is a high-value tropical mariculture species. The present study evaluated the gut microbial impact of therapeutic exposure (80 mg/day/kg biomass for 10 days) to oxytetracycline, the most common aquaculture antibiotic in T. blochii.

Formulation of Asiatic acid-loaded polymeric chitosan-based hydrogel for effective MRSA infection control and enhanced wound healing in zebrafish models.

Background: Wound healing relies on a controlled inflammatory process vital for tissue regeneration. Chronic wounds, characterized by persistent inflammation and high infection risk, pose significant challenges in healthcare. Hydrogel dressings offer promise in wound care; however, the understanding of their role in managing inflammation and infection remains unclear.

Coamorphous systems of rebamipide: Selection of amino acid coformers based on protein-ligand docking, in vitro assessment and study of interactions by computational and multivariate analysis.

Three coamorphous systems of Rebamipide (REB) with the amino acids namely, Tryptophan (TRP), Phenylalanine (PHE) and Arginine (ARG) are reported. A unique approach for the virtual screening of amino acid coformers is presented by employing molecular docking studies based on interactions of the drug molecule with various amino acid fragments in the drug-receptor cocrystal structure. Successful formation of stable coamorphous systems with ARG, TRP and PHE served as the proof-of-concept along with negative benchmarking standards Histidine and Aspartic acid, wherein coamorphous systems could not be obtained despite multiple trials which resulted in crystalline physical mixtures.

Biochemical and steady-state kinetic analyses of arsenate reductases from an arsenic-tolerant strain of Citrobacter youngae IITK SM2.

Arsenic (As) poisoning in aquifers is a serious problem worldwide, especially in the middle-Gangetic Plain (MGP) of India. Microbially-mediated As speciation in such aquifers is governed by the arsenate-reductase enzyme, ArsC, encoded by the arsC gene of As-metabolizing bacteria. In this study, ArsC1 (119 aa) and ArsC2 (141 aa) of a highly resistant strain to arsenic, Citrobacter youngae IITK SM2 (CyIITKSM2), isolated from a mixed-oxic MGP groundwater were biochemically characterized.

Unlocking Job Involvement: Helping New Employees Navigate using Uncertainty Reduction Theory with Psychological Safety as a Mediator.

Organizational socialization (OS) is a critical process that all employees go through. In addition to the job characteristics, the efficiency and effectiveness of the OS process impact the individual's ability to adjust and be involved in the job. This study proposes and tests a new model in which psychological safety mediated the effects of OS and job characteristics on the job involvement of 313 newly recruited health-care professionals' working in 10 private hospitals in South India.

Mesalamine loaded ethyl cellulose nanoparticles: optimization andevaluation of antioxidant potential in ulcerative colitis.

This study aimed to optimize mesalamine (MES)-nanoparticles (NPs) using Box Behnken Design and investigate itsantioxidant potential in colon drug targeting. The formulation was prepared using oil/water (O/W) emulsion solvent evaporation technique for time dependent colonic delivery. The optimal formulation with the following parameters composition was selected: polymer concentration (% w/w) (A) = 0.

Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.

Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure.

A surface modified laser-induced graphene based flexible biosensor for multiplexed sweat analysis.

The growing popularity of electrochemical sensors featuring non-invasive biosensing technologies has generated significant enthusiasm for continuous monitoring of bodily fluid biomarkers, potentially aiding in the early detection of health issues in individuals. However, detection of multiple biomarkers in complex biofluids often necessitates a high-density array which creates a challenge in achieving cost-effective fabrication methods. To overcome this constraint, this work reports the fabrication of an electrochemical sensor utilizing a NiO-TiCT MXene-modified flexible laser-induced graphene (LIG) electrode for the separate and concurrent analysis of ascorbic acid (AA), dopamine (DA), and uric acid (UA) in human sweat and also addresses the deficiencies in the existing state of the art by offering a cost-efficient and high-performance sensor that mitigates the degrading constraints of conventional LIG electrodes.

Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis.

Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness and adverse side effects. To address these challenges, we developed inflammation-targeting nanoparticles (ITNPs) using biopolymers derived from the gum kondagogu (Cochlospermum gossypium) plant.

Iodine-Catalyzed Regioselective C-3 Chalcogenation of 7-Azaindoles: Access to Benzothiophene-Fused 7-Azaindole Analogs.

An iodine-catalyzed method has been reported for efficient regioselective C-3 sulfenylation, selenylation, thiocyanation, and selenocyanation of -free 7-azaindoles using thiophenols, diselenides, potassium thiocyanates, and selenocyanates, respectively. This approach showcases high efficiency and remarkable versatility, facilitating the synthesis of diverse chalcogenated 7-azaindoles. Additionally, the sulfenylated derivatives have been further diversified to generate a new array of benzothiophene-fused 7-azaindole cores of pharmaceutical interest.

MARTINI Coarse-Grained Force Field for Thermoplastic Starch Nanocomposites.

Thermoplastic starch (TPS) is an excellent film-forming material, and the addition of fillers, such as tetramethylammonium-montmorillonite (TMA-MMT) clay, has significantly expanded its use in packaging applications. We first used an all-atom (AA) simulation to predict several macroscopic (Young's modulus, glass transition temperature, density) and microscopic (conformation along 1-4 and 1-6 glycosidic linkages, composite morphology) properties of TPS melt and TPS-TMA-MMT composite. The interplay of polymer-surface (weakly repulsive), plasticizer-surface (attractive), and polymer-plasticizer (weakly attractive) interactions leads to conformational and dynamics properties distinct from those in systems with either attractive or repulsive polymer-surface interactions.

Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.

Efficient and safe gene delivery is vital for genetic manipulation of stem cells for regenerative medicine. Gold nanoparticles have been used for various biomedical applications in the past, and are currently being researched as transfection agents. In this study, we report a simple one-pot synthesis of positively charged gold nanoparticles functionalized with cysteamine.

Auxiliary effect of trolox on coenzyme Q restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway.

Reactive oxygen species (ROS) are essential for cancer signalling pathways and tumour maintenance, making ROS targeting a promising anti-cancer strategy. Coenzyme Q (CoQ10) has been shown to be effective against various cancers, but its impact on retinoblastoma, alone or with trolox, remains unreported. Cytotoxicity of CoQ alone and with trolox was evaluated in normal human retinal pigment epithelium cells (ARPE-19) and Y79 retinoblastoma cells using CCK-8.

Nitrogen Doped Carbon Quantum Dots as Fluorescence "Turn-Off-On" Sensor for Detection of Fe Ions and Ascorbic Acid in Moringa oleifera and Citrus Lemon.

In recent year, the uses of carbon quantum dots (CQDs) have increased in many fields. Herein we report, synthesis of fluorescent nitrogen doped carbon quantum dots (N-CQDs) by simple and ecofriendly hydrothermal method. The as-synthesized N-CQDs were characterized by various techniques and the quantum yield was also calculated.

The synergistic anti-Warburg efficacy of temozolomide, metformin and epigallocatechin gallate in glioblastoma.

An important hallmark of glioblastoma aggressiveness is its altered metabolism of glucose. This metabolic shift wherein the tumor cells employ aerobic glycolysis regardless of oxygen availability via reprogramming of mitochondrial oxidative phosphorylation is known as the Warburg effect. Previous literatures have linked this metabolic reprograming to tumor progression and glioblastoma cell proliferation making it a key target for targeted drug therapy.

Neuro-leishmaniasis with cauda equina syndrome and cranial nerve palsy: a rare manifestation of recurrent atypical visceral leishmaniasis.

Background: Visceral leishmaniasis (VL) is a neglected tropical disease primarily affecting Brazil, East Africa, and India, with India accounting for 18% of the global burden. While VL typically presents with systemic symptoms like fever, weight loss, and splenomegaly, it can occasionally manifest atypically, posing significant diagnostic challenges. Neurological presentations of VL are extremely rare, making them difficult to suspect and diagnose.