250 results match your criteria: " Heidelberg University Hospital[Affiliation]"
Comparison of different dose accumulation strategies to estimate organ doses after stereotactic magnetic resonance-guided adaptive radiotherapy.
Radiat Oncol
May 2023
Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Article Synopsis
- Re-irradiation is common in precision oncology, but it's crucial to monitor previous doses to organs-at-risk (OAR) to prevent overdose, especially when using advanced techniques like SMART for targeting tumors near OAR.
- The study analyzed 18 patients with lung or liver tumors, comparing different dose accumulation methods by assessing cumulative doses in both the planning target volumes (PTV) and OAR across adaptive and theoretical treatments.
- Results showed significant dose increases to OAR, especially in the spinal cord, heart, and gastrointestinal areas during adaptive treatments, suggesting a risk of overdoses, while maintaining comparable PTV coverage compared to baseline plans.
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation.
N Engl J Med
June 2023
From the Department of Neurology, University Hospital Basel, University of Basel, Basel (U.F., T.K.), the Department of Neurology (U.F., S.A., K.N., M.G., M.A., C. Ferrari, S.B., C.B., D.J.S., T.H.), the Support Center for Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology (B.J.W.), and the Institute for Diagnostic and Interventional Neuroradiology (S.F., B.R.-K., A.H., J.G.), University Hospital Bern, and CTU Bern (M.B., S.T.), Institute of Social and Preventive Medicine (G.S.), University of Bern, Bern, the Department of Neurology, University Hospital Lausanne, University of Lausanne, Lausanne (P.M., A.S.), the Department of Neurology, Cantonal Hospital Aarau, Aarau (K.N., T.K.), the Research Department, Reha Rheinfelden, Rheinfelden (L.H.B.), and the Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen (J.V.) - all in Switzerland; the Departments of Cerebrovascular Medicine (M. Koga, K.T.) and Neurology (T.Y.), National Cerebral and Cardiovascular Center, Osaka, the Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi (K.M.), and the Department of Neurology, Kansai Medical University, Hirakata (Y.Y.) - all in Japan; the Department of Neurology, Helsinki University Hospital, and University of Helsinki, Helsinki (D.S., M.T., S.R.); Internal, Vascular, and Emergency Medicine, Stroke Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia (M.P., D.G.), and the Department of Human Neurosciences, University La Sapienza, Rome (N.C.) - both in Italy; the Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg (G.T.), the Department of Neurology, Heidelberg University Hospital (C.G.), and the Department of Neurology, Medical Faculty Mannheim, University of Heidelberg (A.A.), Heidelberg, the Department of Neurology and Stroke and the Hertie Institute for Clinical Brain Research, Tübingen University, Tübingen (S.P.), and the Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg (C. Fung) - all in Germany; the Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece (G.N.); the Department of Neurology, and the Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz (T.G., M. Kneihsl), and the Department of Neurology 2, Kepler University Hospital, Johannes Kepler University, Linz (C.K.) - both in Austria; the Department of Neurology, Oslo University Hospital (E.-C.S.), the Department of General Practice, University of Oslo (E.K.), and the Norwegian Air Ambulance Foundation (E.-C.S.), Oslo, and the Department of Neurology, Akershus University Hospital, Lørenskog (E.K.) - all in Norway; the Department of Neurology, Mater Misericordiae University Hospital, Dublin (P.K.); KU Leuven, Department of Neurosciences, Experimental Neurology, and the Department of Neurology, University Hospitals Leuven, Leuven (R.L., J. Demeestere), the Department of Neurology, Comprehensive Stroke Unit, CHC MontLégia Hospital, Liège (P.D.), the Department of Neurology, Algemeen Ziekenhuis Groeninge Kortrijk, Kortrijk (P.V.), the Neurovascular Center and Stroke Unit Antwerp, Antwerp University Hospital, and the Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp (P.V.), and the Department of Neurology, Ghent University Hospital, Ghent (D.H.) - all in Belgium; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India (P.N.S.); the Stroke Center, Lisbon Central University Hospital (D.A.S., A.P.N.) and Faculty of Medicine, University of Lisbon (D.A.S.) - both in Lisbon, Portugal; the Department of Neurology, Shaare Zedek Medical Center, Jerusalem (N.M.B.); the Department of Neurology, Faculty of Medicine, Pavol Jozef Safarik University, and University Hospital Louis Pasteur - both in Košice, Slovakia (Z.G.); Glan Clwyd Hospital, Betsi Cadwaladr University Health Board, Rhyl (H.T., R.H.), the Stroke Unit, Morriston Hospital, Swansea Bay University Health Board, Swansea (M. Krishnan, P.S.), the Stroke Department, University Hospital of North Durham, Durham (G.C.S.), the Department of Neurology, St. George's University Hospital (L.Z.), and the Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, University College London (D.J.W.), London, and the School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow (J. Dawson) - all in the United Kingdom; and the Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, and the Department of Neurology, Sahlgrenska University Hospital - both in Gothenburg, Sweden (T.T.).
Background: The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear.
Methods: We performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a minor or moderate stroke or on day 6 or 7 after a major stroke) or later anticoagulation (day 3 or 4 after a minor stroke, day 6 or 7 after a moderate stroke, or day 12, 13, or 14 after a major stroke).
Quality assurance and temporal stability of a 1.5 T MRI scanner for MR-guided Photon and Particle Therapy.
Z Med Phys
May 2023
National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; Department of Radiation Oncology, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany. Electronic address:
Purpose: To describe performance measurements, adaptations and time stability over 20 months of a diagnostic MR scanner for integration into MR-guided photon and particle radiotherapy.
Material And Methods: For realization of MR-guided photon and particle therapy (MRgRT/MRgPT), a 1.5 T MR scanner was installed at the Heidelberg Ion Beam Therapy Center.
Pulmonary magnetic resonance-guided online adaptive radiotherapy of locally advanced: the PUMA trial.
Radiat Oncol
May 2023
Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Background: Patients with locally-advanced non-small-cell lung cancer (LA-NSCLC) are often ineligible for surgery, so that definitive chemoradiotherapy (CRT) represents the treatment of choice. Nevertheless, long-term tumor control is often not achieved. Intensification of radiotherapy (RT) to improve locoregional tumor control is limited by the detrimental effect of higher radiation exposure of thoracic organs-at-risk (OAR).
View Article and Find Full Text PDF[Validity of the German Menière's Disease Patient-Oriented Symptom Severity Index].
Laryngorhinootologie
November 2023
Hals-, Nasen- und Ohrenklinik, Heidelberg University Hospital Head Clinic Center, Heidelberg, Germany.
Background: The MD POSI is a disease-specific questionnaire to determine the health-related quality of life (HRQoL) of patients with Menière's disease (MD).
Objectives: Validity and reliability of the German translation of the MD POSI.
Material And Methods: Prospective data analysis of a patient group with vertigo (n = 162), which was treated in the otorhinolaryngology of a University Hospital from 2005-2019.
Palliative Radiotherapy for Symptomatic Locally Advanced Breast Cancer.
Technol Cancer Res Treat
April 2023
Department of Radiation Oncology, 27178Heidelberg University Hospital, Heidelberg, Germany.
Women with locally advanced breast cancer (LABC) or inoperable local recurrence often suffer from a significantly reduced quality of life (QOL) due to local tumor-associated pain, bleeding, exulceration, or malodorous discharge. We aimed to further investigate the benefit of radiotherapy (RT) for symptom relief while weighing the side-effects. Patients who received symptom-oriented RT for palliative therapy of their LABC or local recurrence in the Department of Radiation Oncology at Heidelberg University Hospital between 2012 and 2021 were recorded.
View Article and Find Full Text PDFSpecialist Perspectives on the Imaging Selection of Large Vessel Occlusion in the Late Window.
Clin Neuroradiol
September 2023
Neurology, Boston Medical Center, Boston, USA.
Background: The proper imaging modality for use in the selection of patients for endovascular thrombectomy (EVT) presenting in the late window remains controversial, despite current guidelines advocating the use of advanced imaging in this population. We sought to understand if clinicians with different specialty training differ in their approach to patient selection for EVT in the late time window.
Methods: We conducted an international survey of stroke and neurointerventional clinicians between January and May 2022 with questions focusing on imaging and treatment decisions of large vessel occlusion (LVO) patients presenting in the late window.
MR-Class: A Python Tool for Brain MR Image Classification Utilizing One-vs-All DCNNs to Deal with the Open-Set Recognition Problem.
Cancers (Basel)
March 2023
Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, 69120 Heidelberg, Germany.
Background: MR image classification in datasets collected from multiple sources is complicated by inconsistent and missing DICOM metadata. Therefore, we aimed to establish a method for the efficient automatic classification of MR brain sequences.
Methods: Deep convolutional neural networks (DCNN) were trained as one-vs-all classifiers to differentiate between six classes: T1 weighted (w), contrast-enhanced T1w, T2w, T2w-FLAIR, ADC, and SWI.
To fly or not to fly: Stereotactic MR-guided adaptive radiotherapy effectively treats ultracentral lung tumors with favorable long-term outcomes.
Lung Cancer
May 2023
Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:
Background: Stereotactic radiotherapy of ultracentral lung tumors (ULT) is challenging as it may cause overdoses to sensitive mediastinal organs with severe complications. We aimed to describe long-term outcomes after stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) as an innovative treatment of ULT.
Patients & Methods: We analyzed 36 patients that received SMART to 40 tumors between 02/2020 - 08/2021 inside prospective databases.
Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation.
Ann Neurol
July 2023
Department of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Basel, Switzerland.
Article Synopsis
- Cerebral microbleeds increase the risk of both ischemic stroke and intracranial hemorrhage, complicating treatment choices for patients with atrial fibrillation on various antithrombotic therapies.
- A study analyzed 7,839 patients, finding that microbleeds significantly raised the relative risk of intracranial hemorrhage (2.74 times) and ischemic stroke (1.29 times), particularly with combination therapies of anticoagulants and antiplatelets.
- For patients on combination therapy, those with multiple microbleeds faced a higher absolute risk of intracranial hemorrhage compared to ischemic stroke, indicating a need for more research to develop effective preventive strategies.
Management of initial and recurrent radiation-induced contrast enhancements following radiotherapy for brain metastases: Clinical and radiological impact of bevacizumab and corticosteroids.
Clin Transl Radiat Oncol
March 2023
Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
Purpose: The appearance of radiation-induced contrast enhancements (RICE) after radiotherapy for brain metastases can go along with severe neurological impairments. The aim of our analysis was to evaluate radiological changes, the course and recurrence of RICE and identify associated prognostic factors.
Methods: We retrospectively identified patients diagnosed with brain metastases, who were treated with radiotherapy and subsequently developed RICE.
MR Intensity Normalization Methods Impact Sequence Specific Radiomics Prognostic Model Performance in Primary and Recurrent High-Grade Glioma.
Cancers (Basel)
February 2023
Clinical Cooperation Unit (CCU) Radiation Oncology, German Cancer Research Centre, INF 280, 69120 Heidelberg, Germany.
Purpose: This study investigates the impact of different intensity normalization (IN) methods on the overall survival (OS) radiomics models' performance of MR sequences in primary (pHGG) and recurrent high-grade glioma (rHGG).
Methods: MR scans acquired before radiotherapy were retrieved from two independent cohorts (rHGG C1: 197, pHGG C2: 141) from multiple scanners (15, 14). The sequences are T1 weighted (w), contrast-enhanced T1w (T1wce), T2w, and T2w-FLAIR.
Combined Hyperthermia and Re-Irradiation in Non-Breast Cancer Patients: A Systematic Review.
Cancers (Basel)
January 2023
Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Purpose: This systematic literature review summarizes clinical studies and trials involving combined non-ablative hyperthermia and re-irradiation in locoregionally recurrent cancer except breast cancer.
Methods: One database and one registry, MEDLINE and clinicaltrials.gov, respectively, were searched for studies on combined non-ablative hyperthermia and re-irradiation in non-breast cancer patients.
High-risk patients with locally advanced non-small cell lung cancer treated with stereotactic body radiation therapy to the peripheral primary combined with conventionally fractionated volumetric arc therapy to the mediastinal lymph nodes.
Front Oncol
January 2023
Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Introduction: A very narrow therapeutic window exists when delivering curative chemoradiotherapy for inoperable locally advanced non-small cell lung cancer (NSCLC), particularly when large distances exist between areas of gross disease in the thorax. In the present study, we hypothesize that a novel technique of stereotactic body radiation therapy (SBRT) to the primary tumor in combination with volumetric arc therapy (VMAT) to the mediastinal lymph nodes (MLN) is a suitable approach for high-risk patients with large volume geographically distant locally advanced NSCLC.
Patients And Methods: In this single institutional review, we identified high-risk patients treated between 2014 and 2017 with SBRT to the parenchymal lung primary as well as VMAT to the involved MLN using conventional fractionation.
CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study.
Cancer
March 2023
Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada.
Background: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC.
View Article and Find Full Text PDFDosimetric Benefit of Adaptive Magnetic Resonance-Guided Stereotactic Body Radiotherapy of Liver Metastases.
Cancers (Basel)
December 2022
Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
(1) Background: To assess dosimetry benefits of stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) of liver metastases. (2) Methods: This is a subgroup analysis of an ongoing prospective registry including patients with liver metastases. Patients were treated at the MRIdian Linac between February 2020 and April 2022.
View Article and Find Full Text PDFRadiotherapy with Helium Ions Has the Potential to Improve Both Endocrine and Neurocognitive Outcome in Pediatric Patients with Ependymoma.
Cancers (Basel)
November 2022
Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Ependymomas are the third most-frequent pediatric brain tumors. To prevent local recurrence, the resection site should be irradiated. Compared to photon radiation treatment, proton therapy often achieves even better results regarding target coverage and organ-sparing.
View Article and Find Full Text PDFIntensity modulated proton therapy for early-stage glottic cancer: high-precision approach to laryngeal function preservation with exceptional treatment tolerability.
Radiat Oncol
December 2022
Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Background: Due to the increasing expertise in transoral laser surgery and image-guided radiation therapy, treatment outcomes have recently improved in patients with early-stage glottic cancer. The objective of the current study was to evaluate intensity-modulated proton therapy (IMPT) as novel treatment option.
Methods: A total of 15 patients with T1-2N0 glottic squamous cell carcinoma, treated between 2017 and 2020, were evaluated.
CerebNet: A fast and reliable deep-learning pipeline for detailed cerebellum sub-segmentation.
Neuroimage
December 2022
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA. Electronic address:
Quantifying the volume of the cerebellum and its lobes is of profound interest in various neurodegenerative and acquired diseases. Especially for the most common spinocerebellar ataxias (SCA), for which the first antisense oligonculeotide-base gene silencing trial has recently started, there is an urgent need for quantitative, sensitive imaging markers at pre-symptomatic stages for stratification and treatment assessment. This work introduces CerebNet, a fully automated, extensively validated, deep learning method for the lobular segmentation of the cerebellum, including the separation of gray and white matter.
View Article and Find Full Text PDFGlobal Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
Neurology
January 2023
From the Department of Neurology (T.N.N., P.K., Anvitha Sathya, H.C.L., Andreas Charidimou, Judith Clark, S.K.F., J.R.R.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiology (T.N.N., M.M.Q., P.K., Mohamad Abdalkader, Anvitha Sathya, H.C.L., N.L.K.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Radiation Oncology (M.M.Q.), Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine; Department of Stroke Neurology (H.Y.), National Hospital Organization, Osaka National Hospital, Japan; Department of Neurology (R.M., Petra Sedova), International Clinical Research Centre, St Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; 2nd Department of Neurology (Anna Czlonkowska, M.A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Internal Medicine and Cardiology (Petra Sedova), University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurology (O.Y.M.), Alexandria University Stroke and Neurointervention Unit, Egypt; Department of Neurology (H.R.V., K.U.), Cleveland Clinic; Centre Hospitalier de l'Université de Bordeaux (E.L.), INSERM, Bordeaux Population Health Research Center, France; Second Department of Neurology (Georgios Tsivgoulis, Lina Palaiodimou), "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece; Ohio Health Riverside Methodist Hospital (A.I.L.); Neurology Department (J.D., Robin Lemmens), Leuven University Hospital, Belgium; University of Tennessee Health Science Center (V.I., N.G.); Cooper Neurological Institute (J.E.S., J.W.), Cooper University Hospital, Camden, NJ; Department of Neurology (Shadi Yaghi), Rhode Island Hospital, Brown University, Providence; Stroke Center (D.A.S.), Centro Hospitalar Universitário Lisboa Central-CHULC, Portugal, CEEM; Institute of Anatomy (D.A.S.), Faculdade de Medicina, Universidade de Lisboa, Portugal; Department of Neurology (Mahmoud Mohammaden, D.C.H.), Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA; Department of Neurology (E.S.K.), Akershus University Hospital, University of Oslo, Norway and Department of General Practice, University of Oslo, Norway; Division de Neurologia Vascular (V.P.L.), Departmento de Neurologia, Institute for Neurological Research-FLENI, Buenos Aires, Argentina; Stroke Unit (S.D.S.), Ramos Mejia Hospital, Buenos Aires, Argentina; Department of Medicine and Neurology (B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia; Royal North Shore Hospital (Alice Ma), Sydney, Australia; Department of Neurophysiology (J.O.T), Liverpool Hospital, New South Wales, Australia; Department of Neurology (M.W.P.), Liverpool Hospital, New South Wales, Australia; Departments of Neurology (Shaloo Singal) and Radiology (L.-A.S.), Monash Medical Centre, Australia; Stroke and Aging Research Group (Shaloo Singhal), School of Clinical Sciences at Monash Health, Monash University, Australia; Department of Neurology (Rodrigo Tomazini Martins), Mater Hospital, Brisbane, Australia; Department of Neurology (Chris Enzinger), Medical University of Graz, Austria; Department of Neurology and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Medical University of Graz, Austria; Department of Neurology (Aminur Rahman), Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh; Hopital Erasme (T.B., N.L.), Brussels, Belgium; Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Belgium; Department of Neurology (P.V.), University Hospitals Antwerp; Department of Translational Neuroscience (P.V.), University of Antwerp, Belgium; Hospital das Clínicas (A.B.C., I.L.S.), São Paulo University, Brazil; Department of Neurology and Interventional Neuroradiology (R.C.T.H.), Hospital de Base de São José do Rio Preto, São Paulo, Brazil; Department of Neurology (L.O.N., I.B.S.), Hospital São Carlos, Fortaleza, Ceará, Brazil Stroke Unit (Rodrigo Targa Martins), Neurology, Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil; Moinhos de Vento Hospital (D.L.M.C.), Brazil; Hospital de Base do Distrito Federal (L.C.R.), Brasilia, Brazil; St. Anna University Hospital (T.S., Rosen Kalpachki, F.A.), Sofia, Bulgaria; Department of Neurology (Luciana Catanese), McMaster University, Hamilton, Canada; Department of Diagnostic Radiology (E.A.C.), Halifax Infirmary, Dalhousie University, Halifax, Canada; Departments of Clinical Neurosciences and Radiology (M.G., M.D.H.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Canada; Royal University Hospital (M.E.K., Lissa Peeling), Saskatoon, Saskatchewan, Canada; Department of Neurology (H.K.), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, Division of Neurology, Department of Medicine, University of Toronto, Canada; Hopital Enfant Jesus (Pascale Lavoie), Centre Hospitalier de l'Université Laval, Quebec City, Canada; Toronto Western Hospital (A.P.), University of Toronto, Canada; Neuroradiology Department (R.R.), Instituto de Neurocirugía Dr. Asenjo, Santiago, Chile; Department of Neurology (H.-S.C.), General Hospital of Northern Theater Command, Shen Yang, China; Department of Neurology (Y.C., Shuiquan Yang), Foshan Sanshui District People's Hospital, China; Interventional Neuroradiology (X.H., Z.M.), Beijing Tiantian Hospital, China; Department of Neurology (M.R.B.), Sestre Milosrdnice University Hospital Center, Croatia; Department of Neurology (Marina Bralic), Clinical Hospital Center Rijeka, Croatia; Sveti Duh University Hospital - Zagreb (H.B.), Department of Neurology, Croatia; J.J. Strossmayer University of Osijek (H.B.), Faculty of Medicine, Department of Neurology and Neurosurgery, Osijek, Croatia; Department of Neurology (A.B.C.-Q.), Hospital Departamental Universitario del Quindío San Juan de Dios, Colombia; Department of Neurology (O.E.L.-S.), Clínica de la Costa, Barranquilla, Colombia; Department of Neurology (Martin Cabal), Faculty Hospital Ostrava, Czech Republic; Department of Neurology (D.T.), Blansko Hospital, Czech Republic; Oblastní Nemocnice Trutnov a.s. (Petr Fibrich), Czech Republic; Department of Neurology (R.H.), Comprehensive Stroke Center, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic; Neurology (H.H.), Hospital Příbram, Czech Republic; Uherskohradišťská Hospital (E.H.), Czech Republic; Department of Neurology (D.H.), Thomayer University Hospital Prague, Czech Republic; Neurocenter (L.J.), Regional Hospital Liberec, Czech Republic; Neurology (Jana Kadlcikova), Hospital Vyskov, Czech Republic; Regional Hospital Karlovy Vary (Igor Karpowicz), Czech Republic; Ostrava (L.K.), Czech Republic; Na Homolce Hospital (Martin Kovar), Czech Republic; Department of Neurology (D.L.), Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Czech Republic; Department of Neurology (J.N.E.S.O.), Krajská zdravotní, a.s.-Hospital Chomutov, Chomutov, Czech Republic; Karvina Mining Hospital (H.P.), Czech Republic; Neurology (Martin Reiser), České Budejovice Hospital, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience (Petra Rekova), First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic; Department of Neurology (V.R.), University Hospital Plzen, Czech Republic; Department of Neurology (O.S.), Hospital Jihlava, Czech Republic; Department of Neurology (M.Š.), Masaryk University Faculty of Medicine, University Hospital Brno, Czech Republic; Oblastni Nemocnice Kladno (L.S.), Czech Republic; Central Military Hospital in Prague (Martin Sramek), Czech Republic; Nemocnice Třinec (Lenka Zakova), Czech Republic; Copenhagen University Hospital (H.C., N.D.), Denmark; Stroke Center (H.K.I., T.C.T.), Rigshospitalet, University of Copenhagen, Denmark; Neurovascular Center (T.W.), Zealand University Hospital, University of Copenhagen, Roskilde, Denmark; El hussein Alzahar University Hospital (Khalid Sobh), Egypt; Neurocenter (P.Y.), Turku University Hospital, Turku University, Finland; Department of Radiology (K.A.), Turku University Hospital, Finland; Department of Neurology (Daniel Strbian), Helsinki University Hospital and University of Helsinki, Finland; Bayonne Hospital Neurology (P.B.), Stroke Unit, France; Libourne Hospital Neurology (Philippe Casenave), Stroke Unit, France; Centre Hospitalier d'Arcachon-Neurologie (Maria Dan), France; Agen Hospital Neurology (J.-M.F.), Stroke Unit, France; Neuroradiologie Interventionelle (J.-C.G.), Brest University Hospital, France; Neurochirurgie (E.M.), Brest University Hospital, France; Department of Neurology (C.S.), Rothschild Foundation Hospital, Paris, France; Lariboisiere Hospital (Peggy Reiner), Paris, France; Bordeaux University Hospital Neurology (F.R.), Stroke Unit, France; Department of Neurology (F.O.B.), University Hospital, Goethe University, Frankfurt, Germany; Department of Neurology (Stefan Boskamp, Michael Rosenkranz), Albertinen Krankenhaus, Hamburg, Germany; Department of Neurology and Stroke (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Hertie Institute for Clinical Brain Research (Joshua Mbroh, S.P.), Eberhard-Karls University, Tuebingen, Germany; Department of Neurology (Simon Nagel), Klinikum Ludwigshafen, Ludwigshafen/Rhein, Germany; Department of Neurology (Simon Nagel, P.A.R.), Heidelberg University Hospital, Germany; Department of Neurology and Experimental Neurology (C.H.N.), Center for Stroke Research Berlin, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany; Universitätsklinikum Hamburg-Eppendorf (Götz Thomalla), Klinik und Poliklinik für Neurologie, Hamburg, Germany; Second Department of Neurology (Theodoros Karapanayiotides, Ioanna Koutroulou), AHEPA University Hospital, Aristotle University of Thessaloniki, School of Medicine, Faculty of Health Sciences, Greece; Stroke Unit (O.K.), Metropolitan Hospital, Piraeus, Greece; Hospital General San Juan de Dios (J.D.B.G.), Guatemala; Mazumdar Shaw Medical Center (V.H.), Bangalore, Karnataka, India; Department of Neurology (Bindu Menon), Apollo Specialty Hospitals Nellore, Andhra Pradesh, India; Department of Neurology (Shashank Nagendra), Grant Medical College and Sir JJ Hospital, Mumbai, India; Mazumdar Shaw Medical Center (C.P.), Bangalore, Karnataka, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology (P.N.S.), Trivandrum, Kerala, India; Department of Neurology (N.A.K.P.), Faculty of Medicine Udayana University, Sanglah General Hospital Denpasar, Bali, Indonesia; Dr. Soetomo General Hospital Surabaya (A.F.S.), Universitas Airlangga, Indonesia; Stroke Research Group (A.G.), Head of Stroke Care Unit, Department of Neurology, Vali-e-Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Iran; Neurosciences Research Center (Mehdi Farhoudi, E.S.H.), Imam Reza Hospital, Tabriz University of Medical Sciences, Iran; Neurology Department (T.A.R., S.I.S.), Hillel Yaffe Medical Center, Hadera, Israel; Neurointerventional Unit (S.A.K., Levite Ronen), Shamir Medical Center, Israel; Stroke Unit (Maurizio Acampa), University of Siena, Italy; Stroke Center IRCCS Sacro Cuore Don Calabria (A.A.), Verona, Italy; Dipartimento di Neuroradiologia Diagnostica e Interventistica Policinico Universitario IRCCS San Martino (Lucio Castellan, C.R.B.), Genova, Italy; Neurology and Stroke Unit (M.L., Michele Romoli), Ospedale Bufalini, Cesena, Italy; Neuroscience Section (R.O., Simona Sacco), Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; Interventional Neurovascular Unit (Leonardo Renieri), Careggi University Hospital, Florence, Italy; Neurological Department (Andrea Salmaggi, Davide Sangalli), "Alessandro Manzoni" Hospital, ASST Lecco, Via dell'Eremo, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z.), Neurologia e Rete Stroke Metropolitana, Italy; Department of Neurosurgery (R.D., N.K.), Iwate Prefectural Central Hospital, Japan; Department of Neurology (H.F.), Japanese Red Cross Matsue Hospital, Japan; Department of Neurosurgery (T.F.), National Hospital Organization Osaka National Hospital, Japan; Department of Endovascular Surgery (K.F.), Tokyo Medical and Dental University, Japan; Department of Neurosurgery (H.I., N.S.), Kobe City Medical Center General Hospital, Japan; NTT Medical Center Tokyo (Takuya Kanamaru), Japan; Department of Neurology (Ryuhei Kono), Kin-ikyo Chuo Hospital, Japan; Shiroyama Hospital (K.M.), Japan; Department of Neurology (Manabu Sakaguchi), Osaka General Medical Center, Japan; Department of Neurology (Kenichiro Sakai), The Jikei University School of Medicine, Japan; Department of Neurology (Kazutaka Sonoda), Saiseikai Fukuoka General Hospital, SFGH, Japan; Stroke Center (Kenichi Todo), Osaka University Hospital, Japan; Department of Neurology (Fumio Miyashita), Kagoshima City Hospital, Japan; Department of Neurology (N.T.), Japanese Red Cross Kyoto Daini Hospital, Japan; Department of Stroke and Cerebrovascular Diseases (Y.M.), University of Tsukuba Hospital, Japan; Comprehensive Strokology (S.M.), Fujita Health University School of Medicine, Toyoake, Japan; Department of Neurology (N.O.), Kobe City Medical Center General Hospital, Japan; Department of Neurology (Seigo Shindo), Japanese Red Cross Kummoto Hospital, Japan; Osaka Red Cross Hospital (Y.T.), Japan; Department of Neurology (Takeshi Yoshimoto), National Cerebral and Cardiovascular Center, Japan; Department of Cerebrovascular Medicine (Kazunori Toyoda), National Cerebral and Cardiovascular Center, Japan; Cerebrovascular Medicine (T.U.), Stroke Center, Saga Medical Centre Koseikan, Japan; Stroke Medicine (Yoshiki Yagita), Kawasaki Medical School, Japan; Department of Neurology and Stroke Treatment (Takehiro Yamada), Japanese Red Cross Kyoto Daiichi Hospital, Japan; Advanced Brain Research (N.Y.), Tokushima University, Japan; Yokohama Brain and Spine Center (R.Y.), Japan; Department of Stroke Neurology (Yukako Yazawa), Kohnan Hospital, Sendai, Japan; Toyonaka Municipal Hospital (Y.S.), Japan; Kenyatta University Teaching (P.K.W.), Referral and Research Hospital, Kenya; Department of Neurology (J.-H.B.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Neurology (S.B.L.), Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, South Korea; Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea; Department of Neurology (S.-I.S.), Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea; Department of Urgent Neurology (A.A.A.), University Clinic of Neurology, University Ss. Cyril and Methodius-Faculty of Medicine, Skopje, North Macedonia; Hospital Sultan Abdul Halim (Y.C.C.), Malaysia; Department of Medicine (W.A.W.Z.), National University of Malaysia; Department of Surgery (A.S.J.), National University of Malaysia; Neurovascular Unit and Neurology Department (F.G.-R., A.I.-V.), University Hospital Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Mexico; Department of Neurology (M.M.-M.), Hospital de especialidades del Centro Médico Nacional Siglo XXI IMSS, Mexico; "Nicolae Testemitanu" State University of Medicine and Pharmacy (S.G., Pavel Leahu); Emergency Medicine Institute (L.P., S.G.), Chisinau, Republic of Moldova; Amsterdam University Medical Centers Amsterdam (J.M.C., L.A.R.), the Netherlands; Departments of Neurology (D.W.J.D.) and Neurology and Radiology (D.H.K.D.-N.), Erasmus University Medical Center Rotterdam, the Netherlands; Department of Medicine (Annemarei Ranta), University of Otago-Wellington, and Department of Neurology, Wellington Hospital, New Zealand; Department of Neurology (T.Y.W.), Christchurch Hospital, New Zealand; Department of Medical Records (T.T.A.), Federal Medical Centre, Owo, Ondo State, Nigeria; Neurology Unit (A.H.B., K.W.W.), University of Ilorin, Nigeria; Neurology Unit (E.O.N.), Department of Medicine, Federal Medical Centre Owerri, Neurology Unit, Federal Medical Centre, Owerri, Nigeria; Neurology Unit, Department of Medicine, (T.A.S.) Federal Medical Center, Owo, Ondo State, Nigeria; Department of Neurology (O.M.R.), Akershus University Hospital, Norway, and Institute of Clinical Medicine, University of Oslo, Norway; Department of Neurology (E.C.S.), Oslo, Oslo, Norway and The Norwegian Air Ambulance Foundation, Norway; Central Stroke Unit (A.M.A.H.), Neuroscience Directorate, Khoula Hospital, Ministry of Health, Oman; Lahore General Hospital (S.A., U.R.), Pakistan; Departamento de Neurología (L.R.-K., M.Á.V.), Hospital Nacional Edgardo Rebagliati Martins,Essalud, Lima, Perú; St. Luke's Medical Center (P.M.Y.), Global City, Philippines; St. Luke's Medical Center (J.S.H.D., M.C.P.-F., C.O.C.), Quezon City, Philippines; Department of Neurology (W.B.), Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland; Clinic of Neurology (Aleksander Debiec, J.S.), Military Institute of Medicine, Warsaw, Poland; Department of Neurology (Malgorzata Dorobek), Central Clinical Hospital of the Ministry of Interior and Administration (M.D.), Warsaw, Poland; Department of Neurology (B.M.L.-R.), St. Jadwiga Provincial Specialist Hospital in Opole, Institute of Medical Sciences, University of Opole, Poland; Department of Neurology (A.L.-B.), Leszek Giec Upper Silesian Medical Centre of the Silesian Medical University in Katowice, School of Health Sciences, Medical University of Silesia in Katowice, Poland; 1st Department of Neurology (H.S.-J.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Neurology in Sandomierz (Piotr Sobolewski), Collegium Medicum, Jan Kochanowski University in Kielce, Sandomierz, Poland; Department of Neurology (M.W.), Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland; Department of Neurology (J.Z.-T.), Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland; Neuroradiology Department-Centro Hospitalar de Vila Nova de Gaia/Espinho (A.P.A.), Portugal; Neurology Department (Mariana Rocha), Centro Hospitalar Vila Nova de Gaia/Espinho; Department of Neurology (Pedro Castro), Centro Hospitalar Universitário de São João, Portugal; Stroke Unit-Hospital Pedro Hispano (V.T.C., P.V.F.), Matosinhos, Portugal; Stroke Unit (Patricia Ferreira, A.P.N.), Centro Hospitalar Universitário de Lisboa Central, Portugal; Stroke Unit (Luisa Fonseca), Medicine Department, Centro Hospitalar Universitário de São João, Portugal; Department of Neurology (J.P.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal; Hospital de Santa Maria-Centro Hospitalar Lisboa Norte (T.P.M.), Portugal; Department of Neurology (Miguel Rodrigues), Hospital Garcia de Orta, Almada, Portugal; Centro Hospitalar Universitário de São João (M.L.S.), Portugal; Bucarest University Emergency Hospital (Adela Dimitriade), Romania; Department of Neurology (C.F.-P.), County Clinic Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania; Department of Neurology King Fahad Hospital of the University Imam Abdulrahman bin Faisal University Dammam (M.A.H.), Saudi Arabia; Raffles Hospital (N.V.), Singapore; Department of Neurology (G.K., Miroslav Mako), Faculty Hospital Trnava, Slovakia; Jessenius Medical Faculty (G.K., M.M.), Martin, Commenius University, Bratislava, Slovakia; Department of Neurology (G.K.), Slovak Medical University, Bratislava; Complejo Hospitalario Universitario de Albacete (O.A.-M., F.H.-F.), Albacete, Spain; Interventional Neuroradiology (J.B.), Hospital Clínic de Barcelona, Spain; Comprehensive Stroke Center (A.R.-V.), Hospital Clínic de Barcelona, Spain; Department of Neurology (Unidad de Ictus) (A.C.-C.), Hospital Universitario Ramón y Cajal, Madrid, Spain; Stroke Unit (Francisco Moniche), Neurology Department, Hospital Universitario Virgen del Rocío, Spain; Department of Neurology (Joan Montaner, S.P.-S.), Hospital Universitario Virgen Macarena & Neurovascular Research Laboratory, Instituto de Biomedicina de Sevilla-IbiS, Spain; Department of Neuroradiology (M.J.G.S.), Hospital Universitario Rey Juan Carlos, Spain; Department of Neurology (M.G.R.), Hospital Universitario Rey Juan Carlos, Spain; Institute of Neuroscience and Physiology (K.J., A.N.), Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg; Department of Neurology (K.J., A.N.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; Department of Neurology (M.V.M., T.T.P.M.), Karolinska University Hospital & Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Interventional Neuroradiology (G.B.), University Hospitals of Geneva, Switzerland; Department of Neurology (Morin Beyeler, U.F.), Inselspital, Bern University Hospital; Neurocenter (Manuel Bolognese), Cantonal Hospital of Lucerne, Switzerland; Department of Neurology (E.C.), University Hospitals of Geneva, Switzerland; Diagnostic and Interventional Neuroradiology (T.D.), Bern University Hospital, University of Bern, Switzerland; Radiology and Nuclear Medicine (G.M.K.), Cantonal Hospital of Lucerne, Switzerland; University Hospital (E.K.), University of Zurich, Switzerland; Department of Neurology (C.Y.H.), Tainan Sin Lau Hospital, Taiwan; Department of Radiology (Surawan Boonyakarnkul), Ramathibodi Hospital, Mahidol University, Thailand; Department of Radiology (Anchalee Churojana), Siriraj Hospital, Mahidol University, Thailand; Eskisehir Osmangazi University (O.A., M.D.O.), Turkey; Istanbul Aydın University (A.B., Songul Senadim), Florya Medicalpark Stroke Center, Turkey; Cleveland Clinic Abu Dhabi (S.I.H., S.J.), UAE; Department of Stroke Medicine (Soma Banerjee, Joseph Kwan), Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; Stroke (K.K.), Department of Medicine (K.K.), Nottingham University Hospitals NHS Trust, United Kingdom; Neuroradiology (Robert Lenthall), Nottingham University Hospitals NHS Trust, United Kingdom; Barking Havering and Redbridge University Hospitals (Ashok Matthews), Romford, United Kingdom; Royal London Hospital (K.W.), Barts Health NHS Trust, United Kingdom; St George's University Hospital (Liqun Zhang), London, United Kingdom; Valley Hospital Health System (D.A.), Neurosurgeons of NJ, New Jersey; Amita Health and University of Illinois-Chicago (K.S.A.); Inova Fairfax Hospital (Z.B.), Virginia; Neuroscience and Stroke Program (K.B., O.O.Z.), Bon Secours Mercy Health St Vincent Hospital, Toledo, OH; Loyola University Chicago Stritch School of Medicine (J.B.A.N.A., S.R.), Illinois; Inova Fairfax Hospital (S.A.C.), University of Virginia School of Medicine, Virginia; Rush University Medical Center (Michael Chen, Y.R.), Chicago, IL; Department of Neurology (Alex Chebl), Henry Ford Health System, Detroit, MI; Clinical Data Specialist (Jackie Cibulka), EBC Data Abstraction, University of Tennessee Health Science Center; Solution Architect II (Leon Cistrunk), Clinical Decision Support, University of Tennessee Health Science Center; Department of Radiology (Marco Colasurdo), University of Texas Medical Branch, Galveston, TX; Neurology (Alexandra Czap, S.A.S.), UTHealth McGovern Medical School, Houston, TX; Department of Neurology (A.H.), Yale University School of Medicine, New Haven; Brigham and Women's Hospital (S.D.A., A.A.D.), Boston; Baptist Health Medical Center-Little Rock (S.D., K.B.G.), Little Rock, AR; Neurointerventional Program (A.A.D.), Departments of Medical Imaging and Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON; Neuroendovascular Program (A.A.D.), Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Neurology (M.R.E., N.S.R.), Massachusetts General Hospital, Boston; Department of Interventional and Vascular Neurology (Chizoba Ezepue), Neuroscience Center, SSM Health DePaul Hospital, St. Louis, Missouri; University of Iowa (Mudassir Farooqui, S.O.G.); Santa Barbara Cottage Hospital (Lauren Fink, R.A.T.), California; Department of Neurology (U.G.), Saint Louis University School of Medicine, Missouri; Department of Neurology (A.K.G., S.L.), Wake Forest Baptist Medical Center, NC; Wayne State University (M.H.G.N.P., A.M.K.), Detroit, MI; Department of Neurosciences and Comprehensive Stroke Center (M.H., Muhib Khan), Spectrum Health and Michigan State University College of Human Medicine; Department of Neurology (D.J.), Grady Memorial Hospital, Emory University School of Medicine; Department of Neurosurgery (P.T.K.), University of Texas Medical Branch; Department of Neurology (Rakesh Khatri), Texas Tech University Health Science Center, El Paso; HSHS St. John's Hospital (N.N.K.), Southern Illinois University School of Medicine, Springfield; Virginia Hospital Center (B.S.K.); Baptist Health Medical Group (M.K.K.), Baptist Health Lexington, KY; Division of Neurointerventional Radiology (A.L.K., A.S.P.), Department of Radiology, University of Massachusetts Medical Center, Worcester, MA; Community Memorial Hospital (S.L.-H.C.A.,S.C.R.N., N.E.T.), Ventura, CA; Vascular and Neurointerventional Services (G.L.), Saint Louis University, Missouri; Miami Cardiac & Vascular Institute (I.L.), Miami Neuroscience Institute, FL; Dartmouth Hitchcock Medical Center (T.G.L., D.M.R.-S.), Lebanon, NH; Department of Neurology & Neurosurgery (S.S.M.), ECU Health Medical Center, Greenville, NC; Department of Neurology (L.M.), University of Kansas Medical Center; West Virginia University (John Mancin, Ansaar Rai); Department of Neurology (H.M., A.B.R.), SUNY Upstate, Syracuse, NY; Department of Neurology (G.A.M.), Medical University of South Carolina; Department of Neurosurgery (Andre Monteiro, A.H.S.), University at Buffalo; Department of Neurology (F.N.), Pediatrics, Emory University, Georgia; Department of Neurology (K.N.), University of Arkansas for Medical Sciences, Arkansas; Ascension St Johns Medical Center (R.H.R.), Tulsa, OK; Riverside Regional Medical Center (Pankajavalli Ramakrishnan), Newport News, VA; Department of Neurology (Aaron Rothstein), Hospital of the University of Pennsylvania, Philadelphia; University of Colorado School of Medicine (S.S.O.), Aurora, CO; Miami Neuroscience Institute (A.K.S.), Miami; UNC School of Medicine (M.J.W.), North Carolina; University of Utah (K.-H.W.); Hue Central (H.V.L., Q.V.N.), Vietnam; Da Nang Hospital (T.N.P., T.T.N.), Da Nang, Vietnam; Bach Mai Hospital (H.T.P., M.D.T.), Hanoi, Vietnam; Department of Neurology (U.F.), Basel University Hospital, University of Basel, Switzerland; Neurology Service (P.M., Davide Strambo), Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland; Department of Neurology (S.O.M.), Federal University of Rio Grande do Sul, Porto Alegre; Hospital de Clínicas de Porto Alegre (S.O.M.), Brazil; and Department of Neurology (R.G.N.), University of Pittsburgh Medical Center, Pittsburgh. Ondrej Skoda is currently at the Department of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Background And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
View Article and Find Full Text PDFAttitudes of non-participating general practitioners and community pharmacists towards interprofessional medication management in primary care: an interview study.
Int J Clin Pharm
December 2022
Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Background: Interprofessional medication management in primary care is a recognized strategy for improving medication safety, but it is poorly implemented in Germany. As a pilot project, ARMIN [Arzneimittelinitiative Sachsen-Thüringen] was initiated in 2014 to establish better interprofessional medication management between general practitioners and community pharmacists.
Aim: The aim of this study was to explore the views of non-participating general practitioners and community pharmacists towards interprofessional medication management within ARMIN and to identify barriers to participation.
Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model.
Cancer Lett
December 2022
Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:
Radiotherapy can act as an in situ vaccine, activating preventive tumor-specific immune responses in patients. Although carbon ion radiotherapy has superior biophysical properties over conventional photon irradiation, the immunological effects induced by this radiation type are poorly understood. Multiple strategies combining radiotherapy with immune checkpoint inhibition (radioimmunotherapy) to enhance antitumor immunity have been described; however, immune cell composition in tumors following radioimmunotherapy with carbon ions remains poorly explored.
View Article and Find Full Text PDFIdentification of as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS).
Int J Mol Sci
September 2022
Division of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Changes in DNA methylation identified by epigenome-wide association studies (EWAS) have been recently linked to increased lung cancer risk. However, the cellular effects of these differentially methylated positions (DMPs) are often unclear. Therefore, we investigated top differentially methylated positions identified from an EWAS study.
View Article and Find Full Text PDFSafety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial.
Lancet Infect Dis
January 2023
Department of Infectious Diseases and Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany; German Centre for Infection Research, Heidelberg, Germany. Electronic address:
Background: Bulevirtide is a first-in-class peptidic entry inhibitor for hepatitis B virus (HBV) and hepatitis D virus infection. In July, 2020, bulevirtide 2 mg received conditional marketing authorisation by the European Medical Agency for treatment of chronic hepatitis D virus infection. We investigated the antiviral activity of bulevirtide in patients chronically infected with HBV and hepatitis D virus.
View Article and Find Full Text PDFTask sharing in an interprofessional medication management program - a survey of general practitioners and community pharmacists.
BMC Health Serv Res
August 2022
Cooperation Unit Clinical Pharmacy, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Background: Pharmacist-led medication review and medication management programs (MMP) are well-known strategies to improve medication safety and effectiveness. If performed interprofessionally, outcomes might even improve. However, little is known about task sharing in interprofessional MMP, in which general practitioners (GPs) and community pharmacists (CPs) collaboratively perform medication reviews and continuously follow-up on patients with designated medical and pharmaceutical tasks, respectively.
View Article and Find Full Text PDF