Application of machine learning techniques in GlaucomAI system for glaucoma diagnosis and collaborative research support.

This paper proposes an architecture of the system that provides support for collaborative research focused on analysis of data acquired using Triggerfish contact lens sensor and devices for continuous monitoring of cardiovascular system properties. The system enables application of machine learning (ML) models for glaucoma diagnosis without direct intraocular pressure measurement and independently of complex imaging techniques used in clinical practice. We describe development of ML models based on sensor data and measurements of corneal biomechanical properties.

Genistein stimulates the viability and prevents myofibroblastic transformation in human trabecular meshwork cells stimulated by TGF-β.

Primary open-angle glaucoma (POAG) is the most common type of glaucoma leading to blindness. The search for ways to prevent/treat this entity is one of the main challenges of today's ophthalmology. One of such solution seems to be biologically active substances of natural origin, such as genistein (GEN), which can affect the function of isolated trabecular meshwork by the inhibition of protein tyrosine kinase.

Continuous 24-hour measurement of intraocular pressure in millimeters of mercury (mmHg) using a novel contact lens sensor: Comparison with pneumatonometry.

Purpose: To address the unmet need of continuous IOP monitoring, a Pressure-Measuring Contact Lens (PMCL) was developed to measure IOP in millimeters of mercury (mmHg) continuously over 24 hours. The present study assessed the reliability of the novel PMCL.

Methods: In this prospective open-label clinical study, healthy and open-angle glaucoma (OAG) subjects were fitted with the PMCL, and pneumatonometry was performed on study eyes (in absence of the PMCL) and on fellow eyes before, during, and after provocative tests.

First-in-human continuous 24-hour measurement of intraocular pressure and ocular pulsation using a novel contact lens sensor.

Background/aims: This study assessed the feasibility of a novel contact lens device for intraocular pressure (IOP) and ocular pulse amplitude (OPA) continuous measurements over 24 hours.

Methods: This prospective, open-label, single-centre, non-randomised study included glaucoma and healthy subjects. IOP and OPA values acquired by the pressure-measuring contact lens (PMCL) device in one patient's eye at the beginning of the measurement were compared with tonometry values (Goldman applanation tonometry (GAT) and dynamic contour tonometry (DCT)) in the same eye just before PMCL placement.