Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management.

Alzheimer's disease (AD) poses a significant obstacle in today's healthcare landscape, with limited effective treatments. Recent studies have revealed encouraging findings about how exercise-triggered irisin might help slow down the advancement of AD. Irisin, a myokine, released during physical activity, has garnered significant attention for its pleiotropic effects, extending beyond its traditional role in metabolic regulation.

The Impact of Sira Vedha (Phlebotomy) at the Right Elbow Joint in the Treatment of Non-Alcoholic Fatty Liver Disease - A Research Report.

Non-alcoholic fatty liver disease (NAFLD) affects 9%-53% of the Indian population. No Indian studies have examined Sira Vedha (phlebotomy) for NAFLD, although it has been studied for other conditions. Sushruta recommended Sira Vedha at the right elbow joint for liver diseases, but clinical evidence for its efficacy in NAFLD is lacking.

Tobacco Use, Body Mass Index, Potentially Malignant Disorder and Attitude towards Passive Smoking in a Primary Health Centre - A Cross-Sectional Study.

Background And Objective: Primary health center (PHC) settings offer opportunities for tobacco use screening and brief cessation advice. The purpose of this study was to ascertain how thoroughly participants were screened for premalignant lesions associated with smoking and smokeless tobacco use, as well as how closely these lesions correlated with body mass index (BMI).

Methods: In a PHC, 150 participants aged 18 and above participated in this cross-sectional study.

Leucorrhoea Relief: Harnessing the Power of Ayurveda for Natural Healing - A Case Report.

, commonly known as leucorrhea, is a gynecological condition characterized by abnormal vaginal discharge. While it is normal to a certain extent, its pathological manifestation can become severe, often overshadowing the primary cause and prompting patients to seek treatment for this specific symptom. Traditional Ayurvedic approaches to managing (leucorrhea) include addressing the root causes, adopting (kapha mitigating) diet, and employing specific procedures such as vaginal suppositories, douches, and fumigation, alongside symptomatic treatment.

Three-Dimensional Bioprinting as a Tool for Tissue Engineering: A Review.

The field of reconstructive and regenerative therapy has shown an increased amount of interest in three-dimensional (3D) bioprinting techniques in recent years. This technique applies 3D printing methods to tissue engineering, utilizing additive manufacturing techniques and bio-inks containing biomaterials and living cells. 3D bioprinting has the potential to create the lost tissue precisely.

To Study the Iodine Concentration of Mothers' Consumed Salt, Water, and Staple Food in the Neonatal Screening Program of Rural and Urban Vidarbha Region.

Background: This study aimed to examine the iodine concentration in the food items consumed by mothers participating in neonatal screening programs in both areas of the Vidarbha region. A developing fetus relies on a consistent supply of iodine for proper brain and body development. During pregnancy, only the mother can provide the necessary iodine levels.

To Study the Thyroid Hormone Levels in Neonates of Rural and Urban Vidarbha Region.

Background: This study aimed to evaluate thyroid hormone levels in neonates from the rural and urban Vidarbha region. Over the past decade, neonatal hypothyroidism screening has been conducted using filter paper techniques to identify congenital hypothyroidism (CH). In some screening programs, only T4 is measured initially, with TSH assessed if the T4 levels fall below normal.

Management of Carcinoma of Esophagus in Old Patient with Panchagavya Therapy as a Palliative Care-A Case Report.

Esophageal cancer is a male-dominant, aggressive malignancy with a five-year survival rate of 15%-20%, predominantly affecting developed nations. Esophageal squamous cell carcinoma (ESCC) is the most common subtype. This case study involves a 70-year-old man with ESCC, who was suffering from difficulty swallowing, inability to burp, constant nausea, and occasional trouble swallowing water for two months.

Management of Burn Wound in Diabetic Old Patient with Panchagavya Formulations - A Case Report.

Burn injuries are often prevalent and among the most catastrophic injuries encountered in casualty or surgery departments, involving skin and other tissues. These injuries typically result from heat sources such as solids, liquids, or fire, while scalds arise from hot liquids, electricity, chemicals, cold, friction, or radiation. Despite varying causes, the male-female ratio of burn cases remains consistent.

Ayurvedic Management of (Guttate Psoriasis) - A Case Report.

The skin disease in Ayurveda has been classified under , which is classified as and . is type of . A 26-year-old male patient having brown rough-to-touch hard and dry lesions on a lower limb with itching for 2 years has been treated with , followed by treatment.

Case Study on Management of Overweight () through Ayurveda.

Modernization, affluence, and advancements in science and technology have led to increasingly sedentary lifestyles. This unintentionally invites a range of health issues, one of which is (overweight), which can affect physical, mental, and social health. refers to an individual who has excessive fat and flesh accumulation, causing a disproportional enlargement of the buttocks, belly, and breasts without a corresponding increase in energy.

Ayurvedic Approaches to Holistic Management of Polycystic Ovary Syndrome (PCOS).

The female reproductive system relies on the intact uterine adnexa and the hypothalamic-pituitary-ovarian axis. An imbalance can lead to pathogenesis. PCOS is characterized by ovarian cysts, hyperandrogenism, and irregular ovulation.

Effect of Blended Learning Method (Flex Model) on Final-Year Students of BAMS to Learn Shalyatantra.

Background: Blended learning is a blend of online and in-person instruction. This study was conducted to see its effect to learn Shalyatantra topic.

Methodology: Final-year students (58) were equally in two groups.

The prevalence of thromboembolic events among COVID-19 patients admitted to a single centre intensive care unit (ICU): an epidemiological study from a Malaysian population.

Introduction: Thromboembolic (TE) complications in COVID-19 patients are rising globally, contributing significantly to mortality, particularly in severe cases. However, their prevalence, characteristics, and impact on mortality in Malaysia remain unclear.

Objectives: This study aimed to determine the prevalence of thromboembolic (TE) events and associated mortality among COVID-19 patients admitted within a single centre intensive care unit (ICU).

The role of mitochondrial dysfunction in Huntington's disease: Implications for therapeutic targeting.

Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disorder characterized by cognitive decline, motor dysfunction, and psychiatric disturbances. A common feature of neurodegenerative disorders is mitochondrial dysfunction, which affects the brain's sensitivity to oxidative damage and its high oxygen demand. This dysfunction may plays a significant role in the pathogenesis of Huntington's disease.

Transforming healthcare: Saudi Arabia's vision 2030 healthcare model.

Vision 2030 represents Saudi Arabia's strategic socio-economic plan aimed at promoting economic diversification and enhancing living standards. Launched in April 2016, this vision describes an innovative healthcare plan to improve services and outcomes. The merits and drawbacks of public hospitals' 'Model of Care' are examined in this study.

Advanced deep learning algorithms in oral cancer detection: Techniques and applications.

As the 16 most common cancer globally, oral cancer yearly accounts for some 355,000 new cases. This study underlines that an early diagnosis can improve the prognosis and cut down on mortality. It discloses a multifaceted approach to the detection of oral cancer, including clinical examination, biopsies, imaging techniques, and the incorporation of artificial intelligence and deep learning methods.

Effect of Build Orientation on Mechanical and Physical Properties of Additively Manufactured Resins Using Digital Light Processing Technology in Dentistry: A Systematic Review.

Aim: The aim of this systematic review was to evaluate the effect of build orientation on the mechanical and physical properties of additively manufactured resin using digital light processing (DLP).

Background: The properties of 3D-printed materials are influenced by various factors, including the type of additive manufacturing (AM) system and build orientation. There is a scarcity of literature on the effect of build orientation on the mechanical and physical properties of additively manufactured resins using DLP technology in dentistry.

The role of artificial intelligence in pandemic responses: from epidemiological modeling to vaccine development.

Integrating Artificial Intelligence (AI) across numerous disciplines has transformed the worldwide landscape of pandemic response. This review investigates the multidimensional role of AI in the pandemic, which arises as a global health crisis, and its role in preparedness and responses, ranging from enhanced epidemiological modelling to the acceleration of vaccine development. The confluence of AI technologies has guided us in a new era of data-driven decision-making, revolutionizing our ability to anticipate, mitigate, and treat infectious illnesses.

Synergizing GA-XGBoost and QSAR modeling: Breaking down activity aliffs in HDAC1 inhibitors.

The work being presented now combines severe gradient boosting with Shapley values, a thriving merger within the field of explainable artificial intelligence. We also use a genetic algorithm to analyse the HDAC1 inhibitory activity of a broad pool of 1274 molecules experimentally reported for HDAC1 inhibition. We conduct this analysis to ascertain the HDAC1 inhibitory activity of these molecules.

Systems delay in women with breast cancer - A sequential explanatory mixed-methods study from central rural India.

Background: Globally, breast cancer is the most common malignant tumor in both developed and developing nations, with an incidence of 2 million cases every year and around 6 lakh deaths. Even after the availability of healthcare facilities, delays in the management of breast cancer are seen in both developed and developing countries.

Objectives: To assess the patient and system-level delays and to determine the factors that cause the identified delays in women with breast cancer from central rural India.

Unveiling cyclodextrin conjugation as multidentate excipients: An exploratory journey across industries.

The discovery of branched molecules like dextrin by Schardinger in 1903 marked the inception of cyclodextrin (CD) utilization, catalyzing its journey from laboratory experimentation to widespread commercialization within the pharmaceutical industry. CD, a cyclic oligosaccharide containing glucopyranose units, acts as a versatile guest molecule, forming inclusion complexes (ICs) with various host molecules. Computational studies have become instrumental in elucidating the intricate interactions between β-CD and guest molecules, enabling the prediction of binding energy, forces, affinity, and complex stability.

Clinical Chronicles: A Case Report on Pink Tooth of Mummery.

Internal tooth resorption is a subtle proceeding typically occurring in teeth with a history of trauma, chronic pulpal inflammation, or caries-related issues. It is frequently observed in anterior teeth that are more vulnerable and susceptible to injury, but can also affect posterior teeth, often due to pulp involvement in caries. This case report illustrates the handling of a resorption in the cervical third of the root.