134 results match your criteria: "'Victor Babeş' University of Medicine and Pharmacy of Timisoara[Affiliation]"

Noncardiogenic pulmonary edema after cardiac surgery is a rare but severe complication. The etiology remains poorly understood; however, the issue may arise from multiple sources. Possible causes include a significant inflammatory response or an autoimmune process.

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The global burden of cancer as a major cause of death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A and MAO-B, are mammalian mitochondrial enzymes responsible for the oxidative deamination of neurotransmitters and amines in the central nervous system and peripheral tissues with the constant generation of hydrogen peroxide as the main deleterious ancillary product. However, given the complexity of cancer biology, MAO involvement in tumorigenesis is multifaceted with different tumors displaying either an increased or decreased MAO profile.

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Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease.

Mol Cell Biochem

December 2024

Department of Surgery I-Clinic of Surgical Semiotics & Thoracic Surgery, Center for Hepato-Biliary and Pancreatic Surgery, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Sq., No.2, 300041, Timișoara, Romania.

Obesity, diabetes, and their cardiovascular and hepatic comorbidities are alarming public health issues of the twenty-first century, which share mitochondrial dysfunction, oxidative stress, and chronic inflammation as common pathophysiological mechanisms. An increasing body of evidence links the combined exposure to multiple environmental toxicants with the occurrence and severity of metabolic diseases. Endocrine disruptors (EDs) are ubiquitous chemicals or mixtures with persistent deleterious effects on the living organisms beyond the endocrine system impairment; in particular, those known as metabolism-disrupting chemicals (MDCs), increase the risk of the metabolic pathologies in adult organism or its progeny.

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: Thoracic aortic aneurysms (TAAs) are potentially life-threatening medical conditions, and their etiology involves both genetic and multiple risk factors. endocarditis is one of the most frequent causes of blood culture-negative infective endocarditis (BCNIE) in patients with previous cardiac surgery. Our review aims to emphasize the importance of genetic testing in patients with thoracic aortic aneurysms but also the importance of additional testing in patients with suspected endocarditis whose blood cultures remain negative.

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The paper describes a cohort of patients with post-acute COVID-19 syndrome, evaluated for the first time between week 3 and week 12 from the onset of symptoms following the acute COVID-19 infection. The patient's baseline clinical features were used as predictors. The analysis showed that older patients with comorbidities are at higher risk of developing more long-lasting post COVID-19 symptoms.

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  • Our research investigates the relationship between blood levels of MMP-9 and D-dimers and the occurrence of abdominal aortic aneurysms (AAAs) in patients with atherosclerotic coronary disease.
  • We found that patients with severe coronary disease and angina had higher MMP-9 levels, while those with both severe coronary disease and AAAs had lower MMP-9 levels overall.
  • D-dimer levels were notably higher in patients with both AAAs and significant coronary atherosclerosis, suggesting that MMP-9 and D-dimer could serve as useful diagnostic markers for AAAs in these patients.
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  • * Research for this case involved reviewing scientific literature from various sources between 2020 and 2024, revealing limited information on CATs, with only 16 reported cases available and varying postoperative outcomes.
  • * Despite being a young male without certain risk factors, the patient developed a larger LV CAT and was observed for 3 years post-removal, supporting literature claims that complete removal reduces chances of recurrence, although CATs carry a risk of embolization.
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  • The study investigates the long-term health effects on infants born to mothers with COVID-19, focusing on those with congenital gastrointestinal malformations (CGIMs) who required surgery.
  • A total of 41 patients were analyzed, divided into two groups based on their mothers' COVID-19 status, and a one-year follow-up assessed their growth and developmental milestones.
  • Results showed that infants from COVID-19-positive pregnancies (Group 1) had significantly lower height and weight than those from non-COVID-19 pregnancies (Group 2), with a notable prevalence of antibiotic use and malabsorption syndrome in Group 1.
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  • Monoamine oxidases (MAOs) are mitochondrial enzymes that create hydrogen peroxide as a byproduct and have been linked to oxidative stress in heart and metabolic issues.
  • This study examined the role of MAOs in oxidative stress within valvular tissues from 30 patients with severe primary mitral regurgitation, focusing on their interaction with angiotensin 2 (ANG2).
  • Findings revealed that ANG2 exposure increased MAO expression and reactive oxygen species (ROS) levels, which negatively impacted heart function; however, MAO inhibitors and an angiotensin receptor blocker reduced hydrogen peroxide production.
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Spinal muscular atrophy (SMA), identified over a century ago, is characterized by severe muscle wasting and early mortality. Despite its rarity, the high carrier frequency of the responsible genetic mutations and the variability in its manifestations make it a significant research focus. This prospective cross-sectional descriptive study evaluated health-related quality of life (HRQoL) across eight health domains in 43 Romanian SMA patients treated with nusinersen, using the SF-36 questionnaire to analyze influencing factors.

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Background And Aims: The development of dental implantology is based on a thorough examination of the interaction of implants with the surrounding tissues, as well as methods of stimulating osteogenesis around implants. The most common approach to restore lost dentition in terms of function and aesthetics is now represented by implants. The objective of our study was to comparatively assess the efficiency of prosthetic treatments performed on implants alone versus on implants in conjunction with abutment teeth.

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Spinal muscular atrophy (SMA) is a genetic disorder primarily caused by mutations in the SMN1 gene, leading to motor neuron degeneration and muscle atrophy, affecting multiple organ systems. Nusinersen treatment targets gene expression and is expected to enhance the motor function of voluntary muscles in the limbs and trunk. Motor skills can be assessed through specific scales like the Revised Upper Limb Module Scale (RULM) and Hammersmith Functional Motor Scale Expanded (HFMSE).

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Cardiovascular diseases represent the major cause of morbidity mainly due to chronic heart failure. Epicardial (EAT) and perivascular adipose tissues (PVAT) are considered major contributors to the pathogenesis of cardiometabolic pathologies. Monoamine oxidases (MAOs) are mitochondrial enzymes recognized as sources of reactive oxygen species (ROS) in cardiometabolic pathologies.

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In vitro alternative therapy of human epidermoid squamous carcinoma (A431) by superparamagnetic hyperthermia (SPMHT) using FeO (magnetite) superparamagnetic nanoparticles (SPIONs) with an average diameter of 15.8 nm, bioconjugated with hydroxypropyl gamma-cyclodextrins (HP-γ-CDs) by means of polyacrylic acid (PAA) biopolymer, is presented in this paper. The therapy was carried out at a temperature of 43 °C for 30 min using the concentrations of FeO ferrimagnetic nanoparticles from nanobioconjugates of 1, 5, and 10 mg/mL nanoparticles in cell suspension, which were previously found by us to be non-toxic for healthy cells (cell viabilities close to 100%), according to ISO standards (cell viability must be greater than 70%).

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: Phenylketonuria (PKU) is a rare genetic disorder characterized by the inability to convert the essential amino acid phenylalanine into tyrosine. Early dietary treatment can successfully prevent complications, but controversies still exist regarding the attainment of normal growth in these patients. : Eighteen patients with PKU from two Romanian reference centers were compared to eighteen non-PKU controls, matched for age and gender.

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: Dentigerous cysts are one of the most frequent pathologies associated with unerupted or impacted teeth. Such cysts show a male predilection and a preference for the mandibular region. Also, they commonly occur in the second and third decades of life, with only 9% occurring in the first decade.

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Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a novel class of glucose-lowering drugs, have revolutionized the management of heart failure with reduced and preserved ejection fraction, regardless of the presence of diabetes, and are currently incorporated in the heart failure guidelines. While these drugs have consistently demonstrated their ability to decrease heart failure hospitalizations in several landmark clinical trials, their cardioprotective effects are far from having been completely elucidated. In the past decade, a growing body of experimental research has sought to address the molecular and cellular mechanisms of SGLT2i in order to provide a better understanding of the off-target acute and chronic cardiac benefits, beyond the on-target renal effect responsible for blood glucose reduction.

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In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases.

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Background: Premature newborns are at a significant risk for Systemic Inflammatory Response Syndrome SIRS, a condition associated with high morbidity and mortality. This study aimed to evaluate the predictive and diagnostic capability of laboratory markers like Neutrophil to Lymphocyte Ratio (NLR), derived Neutrophil to Lymphocyte Ratio (dNLR), Platelet-to-Lymphocyte Ratio (PLR), and Neutrophil-to-Lymphocyte-to-Platelet Ratio (NLPR) in diagnosing SIRS in premature newborns.

Methods: Premature newborns with and without SIRS were evaluated in a prospective design during a one-year period.

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Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic acid derivative (2-carboxyethylphenylphosphinic acid) and, subsequently, to outline its pharmaco-toxicological profile by employing two different in vitro human cell cultures (keratinocytes-HaCaT-and osteosarcoma SAOS-2 cells), employing different techniques (MTT assay, cell morphology assessment, LDH assay, Hoechst staining and RT-PCR). Additionally, the results obtained are compared with three commercially available phosphorus-containing compounds (P1, P2, P3).

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  • This study examines how different miRNA gene subtypes are expressed in melanoma compared to benign nevi, aiming to find reliable markers for tumor assessment.
  • Conducted from 2019 to 2022, the research involved analyzing 90 samples (45 from advanced melanoma and 45 from pigmented nevi) using PCR arrays and statistical methods.
  • The findings revealed significant upregulation and downregulation of specific miRNAs in melanoma, suggesting their potential as biomarkers for melanoma progression and helping in developing cost-effective diagnostic tools.
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Food neophobia involves avoiding new foods due to reluctance, aversion, or disgust. The Food Neophobia Scale (FNS) is the most reliable and common adult food neophobia test. It helps compare food neophobia across cultures by being translated into numerous languages.

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(1) : Although most cases of new-onset type 1 diabetes mellitus (T1DM) are managed without serious events, life-threatening complications do arise in a subset of patients. Our objective was to assess the correlation between elevated SIRI values and adverse events related to the onset of T1DM. (2) This retrospective study, spanning ten years, included 187 patients with new-onset T1DM divided into three groups based on SIRI tertiles.

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  • Hypocalcemia in pediatric patients can result from various causes and requires fast evaluation to establish severity and appropriate treatment.
  • A case study of a 7-year-old boy highlighted that genetic testing revealed a mutation related to autoimmune polyendocrine syndrome type 1 (APS-1), which complicates diagnosis due to its diverse symptoms.
  • The article reviews APS-1's clinical manifestations and genetic aspects while emphasizing the importance of recognizing gene mutations for better diagnosis and tailored management strategies.
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Lipomatous hypertrophy of the interatrial septum (LHIAS) represents a benign proliferation of lipoid cells at the level of the interatrial septum (IAS) inducing an important thickening of this structure. It respects the fossa ovalis (FO) region, having a typical "hourglass" echocardiographic appearance. There are certain cases though, with unusual appearances and/or with associated pathologies that may induce similar lesions in the heart, in which the differential diagnosis cannot be guaranteed using only the standard methods.

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