134 results match your criteria: "'Victor Babeş' University of Medicine and Pharmacy of Timisoara[Affiliation]"
Diseases
December 2024
Department of Neurology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Noncardiogenic pulmonary edema after cardiac surgery is a rare but severe complication. The etiology remains poorly understood; however, the issue may arise from multiple sources. Possible causes include a significant inflammatory response or an autoimmune process.
View Article and Find Full Text PDFMol Cell Biochem
December 2024
Department XIII Infectious Diseases-Parasitology, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, Timișoara, Romania.
The global burden of cancer as a major cause of death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A and MAO-B, are mammalian mitochondrial enzymes responsible for the oxidative deamination of neurotransmitters and amines in the central nervous system and peripheral tissues with the constant generation of hydrogen peroxide as the main deleterious ancillary product. However, given the complexity of cancer biology, MAO involvement in tumorigenesis is multifaceted with different tumors displaying either an increased or decreased MAO profile.
View Article and Find Full Text PDFMol Cell Biochem
December 2024
Department of Surgery I-Clinic of Surgical Semiotics & Thoracic Surgery, Center for Hepato-Biliary and Pancreatic Surgery, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Sq., No.2, 300041, Timișoara, Romania.
Obesity, diabetes, and their cardiovascular and hepatic comorbidities are alarming public health issues of the twenty-first century, which share mitochondrial dysfunction, oxidative stress, and chronic inflammation as common pathophysiological mechanisms. An increasing body of evidence links the combined exposure to multiple environmental toxicants with the occurrence and severity of metabolic diseases. Endocrine disruptors (EDs) are ubiquitous chemicals or mixtures with persistent deleterious effects on the living organisms beyond the endocrine system impairment; in particular, those known as metabolism-disrupting chemicals (MDCs), increase the risk of the metabolic pathologies in adult organism or its progeny.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department VI Cardiology-Cardiovascular Surgery, "Victor Babes" University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
: Thoracic aortic aneurysms (TAAs) are potentially life-threatening medical conditions, and their etiology involves both genetic and multiple risk factors. endocarditis is one of the most frequent causes of blood culture-negative infective endocarditis (BCNIE) in patients with previous cardiac surgery. Our review aims to emphasize the importance of genetic testing in patients with thoracic aortic aneurysms but also the importance of additional testing in patients with suspected endocarditis whose blood cultures remain negative.
View Article and Find Full Text PDFStud Health Technol Inform
November 2024
Faculty of Automation, and Computers, University Politehnica of Timisoara, Romania.
The paper describes a cohort of patients with post-acute COVID-19 syndrome, evaluated for the first time between week 3 and week 12 from the onset of symptoms following the acute COVID-19 infection. The patient's baseline clinical features were used as predictors. The analysis showed that older patients with comorbidities are at higher risk of developing more long-lasting post COVID-19 symptoms.
View Article and Find Full Text PDFCurr Health Sci J
September 2024
Department of Toxicology and Drug Industry, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.
J Clin Med
October 2024
Institute for Cardiovascular Diseases of Timisoara, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, G. Adam Str. No. 13A, 300310 Timisoara, Romania.
Pediatr Rep
September 2024
Department XI of Pediatric Surgery, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Int J Mol Sci
September 2024
Department III-Pathophysiology, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, E. Murgu Sq. no 2, 300041 Timișoara, Romania.
Neurol Int
August 2024
Department of Genetics, Center of Genomic Medicine, 'Victor Babeş' University of Medicine and Pharmacy of Timișoara, 300041 Timisoara, Romania.
Spinal muscular atrophy (SMA), identified over a century ago, is characterized by severe muscle wasting and early mortality. Despite its rarity, the high carrier frequency of the responsible genetic mutations and the variability in its manifestations make it a significant research focus. This prospective cross-sectional descriptive study evaluated health-related quality of life (HRQoL) across eight health domains in 43 Romanian SMA patients treated with nusinersen, using the SF-36 questionnaire to analyze influencing factors.
View Article and Find Full Text PDFMed Pharm Rep
July 2024
Department of Dentistry, Faculty of Dental Medicine, "Vasile Goldis" Western University of Arad, Romania.
Background And Aims: The development of dental implantology is based on a thorough examination of the interaction of implants with the surrounding tissues, as well as methods of stimulating osteogenesis around implants. The most common approach to restore lost dentition in terms of function and aesthetics is now represented by implants. The objective of our study was to comparatively assess the efficiency of prosthetic treatments performed on implants alone versus on implants in conjunction with abutment teeth.
View Article and Find Full Text PDFBiomedicines
August 2024
Department of Genetics, Center of Genomic Medicine, 'Victor Babeş' University of Medicine and Pharmacy of Timișoara, 300041 Timisoara, Romania.
Spinal muscular atrophy (SMA) is a genetic disorder primarily caused by mutations in the SMN1 gene, leading to motor neuron degeneration and muscle atrophy, affecting multiple organ systems. Nusinersen treatment targets gene expression and is expected to enhance the motor function of voluntary muscles in the limbs and trunk. Motor skills can be assessed through specific scales like the Revised Upper Limb Module Scale (RULM) and Hammersmith Functional Motor Scale Expanded (HFMSE).
View Article and Find Full Text PDFMol Cell Biochem
August 2024
Chair of Pathophysiology, Department III, "Victor Babeş" University of Medicine and Pharmacy of Timișoara, E. Murgu Sq. No. 2, 300041, Timişoara, Romania.
Cardiovascular diseases represent the major cause of morbidity mainly due to chronic heart failure. Epicardial (EAT) and perivascular adipose tissues (PVAT) are considered major contributors to the pathogenesis of cardiometabolic pathologies. Monoamine oxidases (MAOs) are mitochondrial enzymes recognized as sources of reactive oxygen species (ROS) in cardiometabolic pathologies.
View Article and Find Full Text PDFInt J Mol Sci
July 2024
Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
In vitro alternative therapy of human epidermoid squamous carcinoma (A431) by superparamagnetic hyperthermia (SPMHT) using FeO (magnetite) superparamagnetic nanoparticles (SPIONs) with an average diameter of 15.8 nm, bioconjugated with hydroxypropyl gamma-cyclodextrins (HP-γ-CDs) by means of polyacrylic acid (PAA) biopolymer, is presented in this paper. The therapy was carried out at a temperature of 43 °C for 30 min using the concentrations of FeO ferrimagnetic nanoparticles from nanobioconjugates of 1, 5, and 10 mg/mL nanoparticles in cell suspension, which were previously found by us to be non-toxic for healthy cells (cell viabilities close to 100%), according to ISO standards (cell viability must be greater than 70%).
View Article and Find Full Text PDFMedicina (Kaunas)
July 2024
Department of Pediatrics I, Children's Emergency Hospital 'Louis Turcanu', 300011 Timisoara, Romania.
: Phenylketonuria (PKU) is a rare genetic disorder characterized by the inability to convert the essential amino acid phenylalanine into tyrosine. Early dietary treatment can successfully prevent complications, but controversies still exist regarding the attainment of normal growth in these patients. : Eighteen patients with PKU from two Romanian reference centers were compared to eighteen non-PKU controls, matched for age and gender.
View Article and Find Full Text PDFMedicina (Kaunas)
July 2024
Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
: Dentigerous cysts are one of the most frequent pathologies associated with unerupted or impacted teeth. Such cysts show a male predilection and a preference for the mandibular region. Also, they commonly occur in the second and third decades of life, with only 9% occurring in the first decade.
View Article and Find Full Text PDFInt J Mol Sci
July 2024
Centre for Translational Research and Systems Medicine, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, E. Murgu Sq. No. 2, 300041 Timișoara, Romania.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a novel class of glucose-lowering drugs, have revolutionized the management of heart failure with reduced and preserved ejection fraction, regardless of the presence of diabetes, and are currently incorporated in the heart failure guidelines. While these drugs have consistently demonstrated their ability to decrease heart failure hospitalizations in several landmark clinical trials, their cardioprotective effects are far from having been completely elucidated. In the past decade, a growing body of experimental research has sought to address the molecular and cellular mechanisms of SGLT2i in order to provide a better understanding of the off-target acute and chronic cardiac benefits, beyond the on-target renal effect responsible for blood glucose reduction.
View Article and Find Full Text PDFInt J Mol Sci
July 2024
Department of Surgery I-Chair of Surgical Semiotics & Thoracic Surgery, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, E. Murgu Sq. No. 2, 300041 Timişoara, Romania.
In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases.
View Article and Find Full Text PDFClin Pract
June 2024
Department of Surgical Semiology I and Thoracic Surgery, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Background: Premature newborns are at a significant risk for Systemic Inflammatory Response Syndrome SIRS, a condition associated with high morbidity and mortality. This study aimed to evaluate the predictive and diagnostic capability of laboratory markers like Neutrophil to Lymphocyte Ratio (NLR), derived Neutrophil to Lymphocyte Ratio (dNLR), Platelet-to-Lymphocyte Ratio (PLR), and Neutrophil-to-Lymphocyte-to-Platelet Ratio (NLPR) in diagnosing SIRS in premature newborns.
Methods: Premature newborns with and without SIRS were evaluated in a prospective design during a one-year period.
Curr Issues Mol Biol
May 2024
Department of Surgery I, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic acid derivative (2-carboxyethylphenylphosphinic acid) and, subsequently, to outline its pharmaco-toxicological profile by employing two different in vitro human cell cultures (keratinocytes-HaCaT-and osteosarcoma SAOS-2 cells), employing different techniques (MTT assay, cell morphology assessment, LDH assay, Hoechst staining and RT-PCR). Additionally, the results obtained are compared with three commercially available phosphorus-containing compounds (P1, P2, P3).
View Article and Find Full Text PDFCurr Oncol
May 2024
Department of Surgical Semiology I and Thoracic Surgery, "Victor Babes" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Foods
April 2024
Department of Pediatrics I, Children's Emergency Hospital 'Louis Turcanu', 300011 Timisoara, Romania.
Food neophobia involves avoiding new foods due to reluctance, aversion, or disgust. The Food Neophobia Scale (FNS) is the most reliable and common adult food neophobia test. It helps compare food neophobia across cultures by being translated into numerous languages.
View Article and Find Full Text PDFJ Clin Med
April 2024
Department XI Pediatrics, Discipline I Pediatrics, 'Victor Babeş' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
(1) : Although most cases of new-onset type 1 diabetes mellitus (T1DM) are managed without serious events, life-threatening complications do arise in a subset of patients. Our objective was to assess the correlation between elevated SIRI values and adverse events related to the onset of T1DM. (2) This retrospective study, spanning ten years, included 187 patients with new-onset T1DM divided into three groups based on SIRI tertiles.
View Article and Find Full Text PDFJ Clin Med
April 2024
Department XI Pediatrics, Discipline I Pediatrics, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Life (Basel)
April 2024
Department VI-Cardiology, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, 300041 Timișoara, Romania.
Lipomatous hypertrophy of the interatrial septum (LHIAS) represents a benign proliferation of lipoid cells at the level of the interatrial septum (IAS) inducing an important thickening of this structure. It respects the fossa ovalis (FO) region, having a typical "hourglass" echocardiographic appearance. There are certain cases though, with unusual appearances and/or with associated pathologies that may induce similar lesions in the heart, in which the differential diagnosis cannot be guaranteed using only the standard methods.
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