42 results match your criteria: "'Lucian Blaga' University Sibiu[Affiliation]"

Bariatric surgery is an emerging therapeutic approach for obese type 2 diabetes mellitus (T2DM) patients, with proven benefits for achieving target glucose control and even remission of diabetes. However, the effect of bariatric surgery upon diabetic retinopathy is still a subject of debate as some studies show a positive effect while others raise concerns about potential early worsening effects. We performed a systematic review, on PubMed, Science Direct, and Web of Science databases regarding the onset and progression of diabetic retinopathy in obese T2DM patients who underwent weight-loss surgical procedures.

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The review aims to document the new emerging hypervirulent (Kp) endogenous endophthalmitis (EKE) in terms of incidence, microbiological characterization of the pathogenic agent, associated risk factors, management, and outcomes. Hypervirulent (hv) strains of KP (hvKp) induce invasive liver abscesses (LA) with specific clinical features. Up to 80-90% of cases have hepatic liver abscess as a primary focus of infection, followed by renal or lung hvKp infections.

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Article Synopsis
  • The study compared the clinical outcomes and complications of diabetic and non-diabetic patients undergoing emergency cholecystectomy for acute cholecystitis over two years.
  • A total of 46 diabetic patients and 287 non-diabetic patients were analyzed for various factors, including comorbidities, biological variables, and postoperative complications.
  • Although diabetes did not significantly affect the severity of cholecystitis or surgery conversion risk, diabetic patients experienced more postoperative complications, emphasizing the need for careful perioperative management and glycemic control.
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Neonatal brain injury or neonatal encephalopathy (NE) is a significant morbidity and mortality factor in preterm and full-term newborns. NE has an incidence in the range of 2.5 to 3.

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The present study investigated the effects of the COVID-19 pandemic on the clinical presentation and therapeutic management of acute surgical abdomen. A retrospective study of emergency hospitalizations with a diagnosis of acute surgical abdomen between April and July 2020 vs. a similar period in 2019 was performed.

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Article Synopsis
  • The study examines how age affects safety and outcomes of laparoscopic cholecystectomy for acute cholecystitis, analyzing data from 333 patients over two years.
  • These patients were categorized into four age groups, with older age linked to higher severity, complications, and increased conversion to open surgery.
  • Laparoscopic cholecystectomy showed better outcomes in terms of complications and hospital stay compared to open surgery, especially when considering systemic inflammation and specific comorbidities like diabetes in elderly patients.
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This review discusses the evidence on diabetic retinopathy (DR) in patients with diabetic foot ulceration (DFU). A systematic literature review was performed on PubMed, Medline, Springer Nature, and Scopus, following the PRISMA guidelines, using the following terms, individually or in combination: "diabetic foot ulcer" OR "diabetic foot syndrome" OR "DFU" and "diabetic retinopathy." The initial search yielded 648 articles published between 1975 and 2020.

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L. Extract Reduces the Oxidative Stress, Inflammation and Apoptosis in Endothelial Vascular Cells Exposed to Hyperglycemia.

Molecules

August 2020

Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piata 1 Decembrie Street, 410073 Oradea, Romania.

To find new natural remedies in diabetes, this study investigated the biological activity of two extracts obtained from the fruits (PhyF) and herba (PhyH) of L. on human umbilical vein endothelial cells (HUVECs) exposed to normo- and hyperglycemic conditions. The biological effect was quantified by malondialdehyde, IL-31 and IL-33 levels in correlation with physico-chemical characterization and antioxidant activity.

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Stress Hyperglycemia as Predictive Factor of Recurrence in Children with Febrile Seizures.

Brain Sci

February 2020

Research and Telemedicine Center for Neurological Diseases in Children, Pediatric Clinical Hospital Sibiu, 550166 Sibiu, Romania.

Stress hyperglycemia and hyperlactatemia are commonly referred to as markers of stress severity and poor outcome in children with severe acute illness or febrile seizures. Our prospective study aimed to explore the risk factors for stress hyperglycemia and the predictive value of stress hyperglycemia for febrile seizure recurrence. We evaluated as risk factors for blood glucose level, serum lactate, acid-base status, and the clinical parameters relevant to the severity of the infectious context or to febrile seizure event: fever degree, fever duration, seizure type and aspect, seizure duration, and recurrence.

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Article Synopsis
  • - The cutis laxa syndromes are a group of disorders characterized by loose, wrinkled skin and involve various genetic mutations related to elastic fiber formation.
  • - This report focuses on three patients with a specific rare disorder known as Lenz-Majewski syndrome (LMS), marked by unique symptoms like facial dysmorphism, severe growth retardation, and intellectual disability, linked to mutations in the PTDSS1 gene.
  • - The study highlights LMS as a clear example of a cutis laxa syndrome and notes distinctive early signs such as brachydactyly, emphasizing the need for further research on the connection between the PTDSS1 gene and the body's extracellular matrix structure.
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Neuromyelitis optica (NMO) is an inflammatory-demyelinating disease of the central nervous system classically characterized by optic neuritis and severe myelitis. New diagnostic criteria defined neuromyelitis optica spectrum disorder as limited forms of NMO or diverse neurologic presentations in the presence of specific antiaquaporin-4 antibodies. We report the case of a 57-year-old woman admitted in our department for recurrent attacks of optic neuritis, tetraparesis with severe painful tonic spasms of the left limbs and brainstem involvement.

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Introduction: The present report describes a case of sepsis due to Erysipelothrix rhusiopathiae in a patient with B-cell chronic lymphocytic leukemia with no animal exposure, associated with concomitant bronchopneumonia due to Pseudomonas aeruginosa and Escherichia coli.

Case Presentation: A 54-year-old Caucasian man presented to an emergency room with a three-day history of chest pain, fever, cough with purulent sputum, chills and dyspnea. The patient had associated erythematous papules on the chest and enlarged axillary, submandibular, pectoral and supraclavicular lymph nodes, which regressed under treatment with penicillin.

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Introduction: Echinococcosis or hydatidosis is a zoonosis caused by cestodes from the genus Echinococcus; its habitat is the small intestine of the definitive host, represented by dogs/carnivorous animals, where it produces eggs which are eliminated in the environment. Cystic echinococcosis represents more than 95% of the hydatidosis cases registered annually. The most frequent localization is the hepatic one, followed by the pulmonary localization with a ratio of 2.

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Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report.

J Med Case Rep

June 2014

Faculty of Medicine Sibiu, "Lucian Blaga" University Sibiu, Alba-Iulia Str, No,79 23/8, Sibiu 550052, Romania.

Introduction: Opsoclonus-myoclonus syndrome is a very rare neurological disorder associated with some viral infections and exceptionally with the West Nile virus.

Case Presentation: A 57-year-old Caucasian woman presented with fever, dizziness, balance difficulties, vomiting, dancing eye, altered speech, tremor, generalized myoclonus and failure to rise or stand. Our objective is to describe a patient with West Nile infection, which was identified both in her serum and cerebrospinal fluid and was associated with encephalitis and opsoclonus-myoclonus-ataxia syndrome.

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