4,710 results match your criteria: "'G.d'Annunzio' University[Affiliation]"

Objective: To compare the effectiveness and cost of in-vitro fertilization (IVF) with or without preimplantation genetic testing for aneuploidy (PGT-A) when only one or two blastocysts are obtained.

Methods: A dataset was gathered from 1829 patients including 368 non-PGT-A and 1461 PGT-A cycles with one or two blastocysts obtained, between April 2013 and July 2022. Patients were matched 1:1 by propensity-score matching for maternal age, number of metaphase-II oocytes inseminated and number of blastocysts obtained, achieving a database of 242 patients per group.

View Article and Find Full Text PDF

Objective: To report the diagnostic accuracy of cell-free fetal DNA (cfDNA) in detecting fetal chromosomal anomalies in women experiencing miscarriage.

Methods: PubMed, MEDLINE, EMBASE and Cochrane databases were searched from inception to June 2024. The inclusion criteria were women experiencing miscarriage (defined as pregnancy loss before 20 weeks of gestation) who underwent cfDNA screening for trisomies 21, 18 and 13, other autosomal aneuploidies, sex-chromosome aneuploidies and/or copy-number variants (CNVs).

View Article and Find Full Text PDF

Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Moderate-to-severe AD severely affects patients' quality of life. New drugs selectively targeting molecular pathways involved in the pathogenesis of the disease led to a new era for the treatment of AD.

View Article and Find Full Text PDF

Acute local and non-local morphological, sensory and fluid responses to stretching and foam rolling in young females.

Heliyon

October 2024

Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Background: This study aimed to compare and examine the local and non-local effects of a foam rolling (FR) and static stretching (SS) intervention applied to the plantar flexor (PF).

Methods: Fourteen female participants were investigated. Each participant underwent three conditions in a random order at least 48h apart and at the same time of the day: Control (CC), SS, and FR.

View Article and Find Full Text PDF

Factors influencing nurses and nursing students' attitudes towards vaccinations: A cross-sectional study.

Int J Nurs Stud

November 2024

Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland; Department of Nursing, Midwifery and Health, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address:

Background: Vaccination hesitancy remains the main obstacle to improving vaccination coverage. Influenza and COVID-19 vaccination coverage among healthcare professionals is essential. It is crucial to study the vaccination attitudes of healthcare professionals as they significantly influence the vaccination attitudes and behaviour of the rest of the population.

View Article and Find Full Text PDF
Article Synopsis
  • The Itel-MMSE is an easy-to-use telephone screening tool for dementia that gained traction during COVID-19 but needed validation and faced issues like a ceiling effect.
  • This study standardized and validated the Itel-MMSE, recruiting 707 healthy participants and 368 individuals with Mild Cognitive Impairment and Alzheimer's Disease to establish new cut-off scores.
  • Results indicated that the Itel-MMSE is effective in identifying dementia, with strong performance metrics in distinguishing between normal conditions and cognitive impairments, supporting its use in remote screenings.
View Article and Find Full Text PDF
Article Synopsis
  • - Methylphenidate (MPH), often used to treat ADHD, is increasingly misused by individuals with co-occurring psychiatric and substance use disorders, raising concerns about dependence and adverse effects.
  • - A systematic review conducted in 2024 analyzed 12 studies, focusing on patterns of MPH misuse among patients with various psychiatric disorders, including conduct, mood, and anxiety disorders.
  • - The results showed a significant correlation between MPH misuse and individuals with psychiatric disorders, particularly those also suffering from Alcohol Use Disorder, highlighting the need for targeted interventions and monitoring.
View Article and Find Full Text PDF

Introduction: Recent advancements in single-port surgery, robotic platforms, 3D models and artificial intelligence have transformed surgical procedures, especially in urology. These innovations enhance precision, safety, and efficacy, reducing invasiveness and recovery times. The review focuses on the latest in robotic-assisted surgery for genitourinary cancers, highlighting the shift toward personalized, minimally invasive treatments.

View Article and Find Full Text PDF

Managing drug-drug interactions with mavacamten: A focus on combined use of antiarrhythmic drugs and anticoagulants.

Heart Rhythm

November 2024

Barts Heart Centre, Barts Health NHS Trust, London, UK; Center for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, Pennsylvania, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA; Center for Inherited Cardiovascular Disease, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Article Synopsis
  • * Its effectiveness can be influenced by the individual's CYP2C19 genetic profile and interactions with other medications that affect liver enzymes, which could lead to adverse effects or reduced effectiveness.
  • * The paper aims to provide healthcare professionals with guidance on safely prescribing mavacamten alongside commonly used drugs for managing atrial fibrillation in HCM patients, emphasizing the importance of genetic factors and patient safety monitoring.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore how sperm quality (based on WHO-2021 criteria) and paternal factors like BMI and age relate to outcomes in ICSI cycles with PGT-A, focusing on clinical and embryological results.
  • Conducted at a private IVF clinic, the research included data from 3101 couples over several years, employing techniques like trophectoderm biopsies and chromosome testing to evaluate the success of fertilization and embryo development.
  • Results showed that maternal age significantly affected embryo quality, while lower sperm motility and specific conditions like obstructive and non-obstructive azoospermia were linked to poorer outcomes, including live birth rates.
View Article and Find Full Text PDF

Modulation of cerebellar-cortical connectivity induced by modafinil and its relationship with receptor and transporter expression.

Biol Psychiatry Cogn Neurosci Neuroimaging

November 2024

Department of Neuroscience, Imaging, and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Italy; Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University, Chieti-Pescara, Italy; Molecular Neurology Unit, Center for Advanced Studies and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Italy. Electronic address:

Article Synopsis
  • - Modafinil is used to treat narcolepsy and as a cognitive enhancer, impacting the connectivity of brain networks related to attention and executive function, with less known about its effects on subcortical areas.
  • - In a study with 50 participants, researchers measured resting-state fMRI connectivity before and after a single dose of modafinil or a placebo, focusing on cerebellar-neocortical relationships and neurotransmitter receptor expression.
  • - Results showed that modafinil enhanced connectivity in specific cerebellar regions (Crus I and Vermis IX) with prefrontal areas and other brain regions, linking these changes to the presence of dopaminergic and histaminergic receptors.
View Article and Find Full Text PDF

Amyloidosis is a rare multisystem disorder characterized by extracellular accumulation of insoluble fibrils in various organs and tissues. The most common subtype in the pediatric population is systemic reactive amyloidosis, typically developing secondary to chronic inflammatory conditions and resulting in deposition of serum amyloid A protein in association with apolipoprotein HDL3. Clinical presentation is highly variable and is mostly influenced by specific organs involved, precursor protein type, and extent of amyloid deposition, often closely reflecting clinical features of the underlying disease.

View Article and Find Full Text PDF

Peripheral artery disease (PAD) is still the least studied and evaluated form in clinical practice among atherosclerotic pathologies, despite the increased mortality and comorbidities related to it. The relationship between steatotic liver disease and an increased risk of cardiovascular disease has been extensively documented. The purpose of this work is to perform a review of the evidence linking NAFLD or MASLD to PAD, and examine possible clinical scenarios that arise from this new terminology.

View Article and Find Full Text PDF

: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their strong therapeutic activity and excellent safety profiles, azole antifungals are currently the most extensively used systemic antifungal drugs. Antibacterial properties of various topical antifungals, such as oxiconazole, which features oxime ether functionality, were discovered, indicating an exciting prospect in antimicrobial chemotherapy.

View Article and Find Full Text PDF

Autism spectrum disorder (ASD) is a neurological disease and lifelong condition. The treatment gap in ASD has led to growing interest in alternative therapies, particularly in phytocannabinoids, which are naturally present in . Studies indicate that treatment with cannabidiol (CBD)-rich cannabis may possess the potential to improve fundamental ASD symptoms as well as comorbid symptoms.

View Article and Find Full Text PDF

This study aims to identify a metabolomic signature that facilitates the classification of syncope and the categorization of the unexplained syncope (US) to aid in its management. We compared a control group (CTRL, = 10) with a transient loss of consciousness (TLC) group divided into the OH group ( = 23) for orthostatic syncope, the NMS group ( = 26) for neuromediated syncope, the CS group ( = 9) for cardiological syncope, and the US group ( = 27) for US defined as syncope without a precise categorization after first- and second-level diagnostic approaches. The CTRL and the TLC groups significantly differed in metabolic profile.

View Article and Find Full Text PDF

Editorial for Special Issue "Brain Tumor Microenvironment".

Cancers (Basel)

November 2024

Department of Neurosciences, Imaging and Clinical Sciences, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.

The tumor microenvironment (TME) is a complex interplay of cells, extracellular matrix, and signaling molecules that significantly influences tumor growth, invasion, and resistance to therapy [...

View Article and Find Full Text PDF

High-intensity interval training (HIIT) is one of the most debated methods involving several parameters that could be modulated, but the long-term adaptations it induces are still unclear. This investigation aimed to evaluate the efficacy of running and whole-body exercises with high-intensity (>80% heart rate) short intervals (30 s) in body composition and physical performance and compare the effects between groups with active (AR) or passive recovery (PR), both in males and females. : Eighteen trained young adults (55.

View Article and Find Full Text PDF

This study aimed to analyze Optical Coherence Tomography (OCT) parameters and Macular Pigment Optical Density (MPOD) changes in patients affected by Retinitis pigmentosa (RP). Eighteen eyes of 18 patients suffering from early-stage RP were enrolled in our observational study. 18 eyes of 18 patients age and gender matched were enrolled as controls.

View Article and Find Full Text PDF

Background: Fusiform aneurysms are a distinct subgroup of intracranial aneurysms with unique characteristics and pose a treatment challenge compared to common saccular aneurysms. Traditionally, surgery was the main treatment; however, endovascular techniques are gaining favor.

Methods: We searched major databases for studies on treatment, clinical outcomes, and radiological outcomes of intracranial fusiform aneurysms published before May 31st, 2023 in order to compare surgical Vs endovascular treatment strategies.

View Article and Find Full Text PDF

Introduction: The Brief Index of Sexual Functioning for Women (BISF-W) is an international 4-factors tool assessing qualitative and quantitative aspects of sexual experiences in women, both in clinical and experimental settings. The present research aims at validating an Italian version of the BISF-W, to develop a BISF version for men (BISF-M) to fill the gap in the existing sexual function evaluation tools in Italy and to analyze gender and age groups differences in the BISF factors.

Methods: The research included 6,355 women, aged from 18 to 65 ( = 34.

View Article and Find Full Text PDF

Background: The purpose of this study was to determine the accuracy of an intraoral scanner to digitally duplicate complete dentures and analyze the effects of mesh reduction of digital files on the surface area and volume accuracy of complete dentures, in vitro.

Methods: A mandibular complete denture was scanned by a desktop scanner to create a digital STL reference file (control). Fifteen identical scans were created by using an intraoral scanner and exported as STL files (test group).

View Article and Find Full Text PDF

Elevated serum xylitol levels and cardiovascular risk: an active component or an innocent bystander?

Eur Heart J

January 2025

Medicine and Medicine Sub-Specialties Department, Cardio Renal Program, UOC Nephrology, Dialysis and Adult Renal Transplant Program, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.

View Article and Find Full Text PDF