9,442 results match your criteria: "'Federico II' University[Affiliation]"
Beneficial economic effect of a virtual model of care for cystic fibrosis.
Pediatr Pulmonol
January 2025
Cystic Fibrosis Center, Azienda Ospedaliero Universitaria Integrata di Verona, Verona, Italy.
CAR immunotherapy in autoimmune diseases: promises and challenges.
Front Immunol
October 2024
Hebei Key Laboratory of Laboratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
In recent years, the use of chimeric antigen receptor (CAR)-T cells has emerged as a promising immunotherapy in multiple diseases. CAR-T cells are T cells genetically modified to express a surface receptor, known as CAR, for the targeting of cognate antigens on specific cells. The effectiveness of CAR-T cell therapy in hematologic malignancies including leukemia, myeloma, and non-Hodgkin's lymphoma has led to consider its use as a potential avenue of treatment for autoimmune diseases.
View Article and Find Full Text PDFFailure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort.
Ann Surg Oncol
October 2024
Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Background: Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication management. The aim of this study was to evaluate FTR rates after major liver resection for perihilar cholangiocarcinoma (pCCA) and analyze factors associated with FTR.
View Article and Find Full Text PDFResistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease.
Sci Rep
October 2024
Department of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of Naples, Naples, Italy.
This study aimed to evaluate the impact of Fabry disease (FD) on retinal microvasculature using optical coherence tomography angiography (OCTA), arterial stiffness, and the resistive index (RI) of the central retinal artery (CRA) in early disease stages. Twenty-nine genetically confirmed FD patients and twenty-six healthy controls were enrolled. Vessel density (VD) values of the superficial, deep, and choriocapillaris plexuses (SCP, DCP, and CC) were measured via OCTA.
View Article and Find Full Text PDFDegree of food processing and breast cancer risk: a prospective study in 9 European countries.
Food Prod Process Nutr
October 2024
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Unlabelled: Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degree of food processing and breast cancer risk, overall and by breast cancer subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
View Article and Find Full Text PDFGlucose metrics and device satisfaction in adults with type 1 diabetes using different treatment modalities: a multicenter, real-world observational study.
Acta Diabetol
October 2024
Department of Women's and Children's Health, Salesi Hospital, Ancona, 60123, Italy.
Aims: To evaluate glucose metrics, device satisfaction and diabetes impact in adults with type 1 diabetes using different treatment modalities in a real-life setting in Italy.
Methods: This was a multicentre, nationwide, cross-sectional study. Candidates were consecutively evaluated for eligibility during their routine medical visit at the diabetes centre.
SPINE20 Recommendations 2024 -Spinal Disability: Social Inclusion as a Key to Prevention and Management.
Global Spine J
January 2025
Department of Orthopedics, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- Spine disorders are a major global disability issue, highlighting the need for improved access to high-quality spine care to foster social inclusion and dignity for affected individuals.
- SPINE20 outlines six recommendations for G20 countries, including providing evidence-based education for health workers, affordable spine care interventions, and investing in health policy research to support rehabilitation integration.
- Emphasizing the importance of social equity, SPINE20 urges collaborations among healthcare providers and policymakers to ensure comprehensive access to spine care, ultimately aiming to enhance population well-being and productivity.
Massive hemolysis in paroxysmal nocturnal hemoglobinuria after switching from proximal complement inhibitor to anti-C5 therapy: A lesson not to be forgotten.
Am J Hematol
January 2025
Laboratory of Cancer Genetics and Gene Transfer, Core Research Laboratory-Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy.
Distortion errors characterise visuo-constructive performance in Huntington's disease.
Clin Neuropsychol
October 2024
Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Article Synopsis
- Visuospatial deficits in Huntington's disease (HD) have been studied primarily in terms of visuomotor integration, while visuo-constructive abilities have received less attention, prompting this study to explore those abilities qualitatively in comparison to Alzheimer's disease (AD).
- The study included 41 HD participants, 25 with AD, and 35 healthy controls, who performed tasks like the Constructional Apraxia Test and the Rey-Osterrieth Complex Figure test, revealing no significant quantitative differences in performance between the two patient groups.
- Distinct qualitative error patterns were found, with AD participants showing more simplifications in their drawings and HD participants exhibiting more distortions, highlighting the importance of qualitative analysis in understanding cognitive effects of neurological
Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling.
Elife
October 2024
Division of Oral Anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Article Synopsis
- * In mice with mutations in ciliary proteins, abnormal cranial neural crest-derived cells disrupt signaling pathways, leading to improper cell differentiation and subsequent tongue issues like ankyloglossia.
- * The research also indicates that these tongue deformities can be artificially triggered in normal mice, suggesting potential avenues for treatment approaches in ciliopathies.
Role of mentorship in the learning curve of robotic right lobe donor hepatectomy.
Liver Transpl
February 2025
Division of HBP, Department of Clinical Medicine and Surgery, Minimally Invasive and Robotic Surgery, Transplantation Center, Federico II University Hospital, Naples, Italy.
Primary vesicoureteral reflux.
Nat Rev Dis Primers
October 2024
Departments of Paediatrics (Nephrology) and Urology, Wayne State University School of Medicine, Detroit, MI, USA.
Article Synopsis
- Primary vesicoureteral reflux (VUR) is a common condition in children where urine flows backward from the bladder, leading to urinary tract infections and potential kidney damage.
- The primary goals for treating VUR in kids are to prevent UTIs and reduce the risk of kidney problems, with available management options including antibiotics, surveillance, and various surgical techniques.
- Ongoing debates focus on the timing of imaging tests and identifying which patients will benefit most from either antibiotics or surgical treatments, with new technologies like artificial intelligence offering future support in decision-making.
Current management of hepatobiliary malignancies between centers with or without a liver transplant program: A multi-society national survey.
Dig Liver Dis
October 2024
Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
Article Synopsis
- This study looked at how different hospitals approach treating liver cancer, especially regarding liver transplants.
- They surveyed 75 hospital directors to see if those with liver transplant programs treat patients differently compared to those without.
- The results showed that hospitals with transplant programs were more likely to recommend transplants for certain types of liver cancer and other liver diseases than those without, showing a need for better communication between the two types of centers.
Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus.
J Endocrinol Invest
October 2024
Endocrinology Unit, University-Hospital of Udine, Udine, Italy.
Article Synopsis
- The study focused on gathering expert consensus in Italy regarding the management of hypophosphatemia in adults through a Delphi method.
- A multidisciplinary advisory board reviewed existing literature and guidelines, identifying key areas of uncertainty to guide the consensus process.
- The results showed strong agreement on most key issues, underscoring the need for clearer national guidelines to aid healthcare professionals in managing hypophosphatemia effectively.
Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations.
Mol Neurobiol
October 2024
Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.
Article Synopsis
- - The study explored how the transcription factors Nkx2-1 and Pax8 influence thyroid development and brain functions by examining mice with genetic mutations affecting these factors, focusing on brain abnormalities linked to thyroid conditions.
- - DHTP mice, which have both systemic and brain hypothyroidism, displayed altered neurotransmitter systems, reduced expression of synaptic and glutamate receptor proteins, and imbalances in mitochondrial dynamics compared to control mice.
- - The findings suggest that Nkx2-1 and Pax8 mutations lead to neuroanatomical and neurochemical changes in the brain, highlighting potential targets for managing brain dysfunctions related to thyroid imbalances.
Hypomethylation at PANDAR promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes.
FASEB J
October 2024
Department of Translational Medicine, Federico II University of Naples, Naples, Italy.
Article Synopsis
- * Researchers identified PANDAR, a long non-coding RNA (lncRNA), as significantly up-regulated in APCs of individuals with obesity, particularly those transitioning from normal glucose tolerance to impaired glucose tolerance or T2D.
- * Silencing PANDAR in senescent APCs appears to reverse senescence and enable cell cycle re-entry, suggesting that targeting PANDAR may offer a new approach to prevent or delay the progression toward T2D in obese patients.
Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion.
Metabolomics
October 2024
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.
Article Synopsis
- Trimethylamine N-oxide (TMAO) is linked to bad heart health and is produced by gut bacteria, but how exercise affects its production is unclear.
- The study looked at how a single session of intermittent exercise influences TMAO production from choline intake in young, healthy individuals.
- Results showed that TMAO levels increased similarly whether choline was taken after exercise or after resting, indicating exercise doesn't change gut bacteria's behavior regarding TMAO production.
Prolonged Time-to-antihypertensive Therapy Worsens Organ Damage and Blood Pressure Control in Arterial Hypertension.
High Blood Press Cardiovasc Prev
November 2024
Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
Introduction: Delay in arterial hypertension (AH) diagnosis and late therapy initiation may affect progression towards hypertensive-mediated organ damage (HMOD) and blood pressure (BP) control.
Aim: We aimed to assess the impact of time-to-therapy on BP control and HMOD in patients receiving AH diagnosis.
Methods: We analysed data from the Campania Salute Network, a prospective registry of hypertensive patients (NCT02211365).
Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis.
Eur J Prev Cardiol
October 2024
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Article Synopsis
- The study investigated the links between saturated and unsaturated fatty acids and cardiovascular disease (CVD), focusing on conditions like coronary heart disease (CHD) and stroke in a large group of participants.
- Results showed that higher levels of saturated fatty acids were linked to increased CVD risks, with specific subtypes having varying effects on CHD and stroke.
- Conversely, higher concentrations of certain polyunsaturated fatty acids (both n-3 and n-6 types) were associated with lower risks of CHD and stroke, suggesting dietary fats play a significant role in cardiovascular health.
One-month DAPT after biodegradable-polymer everolimus-eluting stent implantation in women at high-bleeding risk: Insights from the POEM trial.
Catheter Cardiovasc Interv
November 2024
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, Italy.
Article Synopsis
- The study aimed to analyze the impact of gender on clinical outcomes after a 1-month dual-antiplatelet therapy (DAPT) period in patients at high bleeding risk undergoing percutaneous coronary intervention (PCI) with bioresorbable polymer everolimus-eluting stent (BP-EES).
- The research found that while women had additional risk factors such as older age and lower hemoglobin levels, they did not show a significantly higher risk for serious complications compared to men after the 1-month DAPT period.
- The results suggest that a short DAPT strategy post-PCI may be a safe and effective option for high bleeding risk women, indicating that sex may not be a critical factor in determining adverse outcomes in this context
Comparing Loop and Divided Colostomy for Anorectal Malformation: A Systematic Review and Meta-Analysis.
J Pediatr Surg
January 2025
Pediatric Surgery Meta-Analysis Study Group (PeSMA), Türkiye; International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, Department of Pediatric Surgery, Aurora, CO, USA.
Introduction: The optimal type of colostomy for patients with anorectal malformations (ARM) remains unclear. We conducted a systematic review and meta-analysis to compare the clinical outcomes of loop colostomies (LC) versus divided colostomies (DC) in patients with ARM.
Methods: After review registration (PROSPERO: CRD42024513335), we searched multiple databases for comparative studies on LCs and DCs in patients with ARMs.
Clarifying the face of cannabis lung.
J Bras Pneumol
September 2024
. Department of Diagnostic Imaging, Section of General Radiology, Azienda Ospedali dei Colli, P.O. Monaldi, Naples, Italy.
Enfortumab Vedotin Following Platinum Chemotherapy and Avelumab Maintenance in Patients with Metastatic Urothelial Carcinoma: A Retrospective Data from the ARON-2 Study.
Target Oncol
November 2024
Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
Article Synopsis
- - Enfortumab vedotin (EV) is effective for patients with advanced urothelial carcinoma who have previously received platinum chemotherapy and immune therapy, despite lacking research on those treated with avelumab maintenance.
- - A study of 182 patients showed a median overall survival of 12.7 months and a progression-free survival of 7.9 months, with 39% achieving a positive response to EV after avelumab treatment.
- - The study confirms EV's effectiveness, suggesting it can be a viable option for patients previously treated with avelumab, with manageable side effects like grade ≥ 3 neuropathy and skin rash occurring in a minority of cases.
Associations between respiratory pathogens and lung function in primary ciliary dyskinesia: cross-sectional analysis from the PROVALF-PCD cohort.
ERJ Open Res
September 2024
Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Article Synopsis
- * Data were collected from 408 PCD patients across 12 countries, focusing on their lung function and the presence of common respiratory pathogens, with a significant finding that those with certain pathogens had lower lung function scores.
- * The results indicated that certain pathogens were strongly associated with decreased lung function, particularly in adults, highlighting the need for early eradication strategies and timely treatment of infections in PCD patients.
Dysphagia assessment in patients with multiple sclerosis - an additional piece to disability burden.
Ann Clin Transl Neurol
November 2024
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Objective: People with multiple sclerosis (MS) might experience symptoms that are usually underestimated. Dysphagia should be evaluated within the Expanded Disability Status Scale (EDSS), but clinicians often do not assess it properly. The objectives of this study are as follows: To assess the prevalence of dysphagia in patients with MS utilizing the Swallowing Disturbance Questionnaire (SDQ); to examine the correlation with the EDSS; to investigate the relationship between dysphagia and clinico-demographic characteristics of MS.
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