Current evidence on the efficacy of mental health smartphone apps for symptoms of depression and anxiety. A meta-analysis of 176 randomized controlled trials.

The mental health care available for depression and anxiety has recently undergone a major technological revolution, with growing interest towards the potential of smartphone apps as a scalable tool to treat these conditions. Since the last comprehensive meta-analysis in 2019 established positive yet variable effects of apps on depressive and anxiety symptoms, more than 100 new randomized controlled trials (RCTs) have been carried out. We conducted an updated meta-analysis with the objectives of providing more precise estimates of effects, quantifying generalizability from this evidence base, and understanding whether major app and trial characteristics moderate effect sizes.

Non-directive supportive therapy for depression: A meta-analytic review.

Background: Non-directive supportive therapy (NDST) is an important treatment of adult depression, but no recent meta-analysis has integrated the randomized trials examining its effects.

Methods: We conducted a meta-analysis comparing NDST to control conditions and to other therapies, by using an existing database of randomized trials of psychological treatments of depression in adults. This database was built through searches in PubMed, PsycINFO, Embase and the Cochrane Library.

Mechanical Properties of MiniBarsâ„¢ Basalt Fiber-Reinforced Geopolymer Composites.

Fly ash-based geopolymers represent a new material, which can be considered an alternative to ordinary Portland cement. MiniBarsâ„¢ are basalt fiber composites, and they were used to reinforce the geopolymer matrix for the creation of unidirectional MiniBarsâ„¢ reinforced geopolymer composites (MiniBarsâ„¢ FRBCs). New materials were obtained by incorporating variable amount of MiniBarsâ„¢ (0, 12.

Simultaneous Determination of Steroids and NSAIDs, Using DLLME-SFO Extraction and HPLC Analysis, in Milk and Eggs Collected from Rural Roma Communities in Transylvania, Romania.

This research aims to determine five steroids and four non-steroidal anti-inflammatory drugs in milk and egg samples collected from rural Roma communities in Transylvania, Romania. Target compounds were extracted from selected matrices by protein precipitation, followed by extract purification by dispersive liquid-liquid microextraction based on solidification of floating organic droplets. The extraction procedure was optimized using a 2 full factorial experimental design.

Advancements in Basal Cell Carcinoma Diagnosis: Non-Invasive Imaging and Multimodal Approach.

(1) Background: The aim of this study was to correlate the diagnostic criteria described in dermatoscopy, ultrasonography (US), ex vivo confocal microscopy, and histology to the most common subtypes of basal cell carcinoma (BCC). (2) Methods: We conducted a prospective study including 46 BCC cases, which were analyzed with dermatoscopy using the Delta 30 dermatoscope and Vidix 4.0 videodermoscope, with US using a high-resolution 20 MHz linear probe, with confocal microscopy, along with histopathological analysis.

The mental health needs of healthcare workers: When evidence does not guide policy. A comparative assessment of selected European countries.

Background: The healthcare workforce (HCWF) globally is facing high stress levels and deteriorating mental health due to workplace, labour market and policy deficiencies that further exacerbate the existing crisis. However, comprehensive and effective action is missing.

Aims: We adopt a health system and governance perspective to address the mental health needs of healthcare workers (HCWs), considering the nature of interventions and the levels and actors involved in governance.

Implementing a singing-based intervention for postpartum depression in Denmark and Romania: a brief research report.

Background: There is a burgeoning evidence-base that demonstrates the positive impact of the arts on our health, wellbeing, and health behaviors. However, very few studies have focused on how to optimize the implementation of these activities for different sociocultural contexts. Due to the increasing interest in scaling effective arts interventions as part of public health strategies, and in line with global goals of achieving health equity, this is an essential focus.

The impact of chronic Trimethylamine N-oxide administration on liver oxidative stress, inflammation, and fibrosis.

TMAO, a gut microbiota derived byproduct, has been associated with various cardiometabolic diseases by promoting oxidative stress and inflammation. The liver is the main organ for TMAO production and chronic exposure to high doses of TMAO could alter its function. In this study, we evaluated the effect of chronic exposure of high TMAO doses on liver oxidative stress, inflammation, and fibrosis.

Connecting molecular biomarkers, mineralogical composition, and microbial diversity from Mars analog lava tubes.

Lanzarote (Canary Islands, Spain) is one of the best terrestrial analogs to Martian volcanology. Particularly, Lanzarote lava tubes may offer access to recognizably preserved chemical and morphological biosignatures valuable for astrobiology. By combining microbiological, mineralogical, and organic geochemistry tools, an in-depth characterization of speleothems and associated microbial communities in lava tubes of Lanzarote is provided.

Anastomotic Leakage after Gastrectomy for Gastric Cancer.

Anastomotic leakage (AL) constitutes a prominent cause of significant morbidity following gastrectomy for gastric cancer. The manifestation of AL typically occurs within 7 to 10 days post-surgery, with reported incidence rates of 5.8-6.

Sharp detection of oscillation packets in rich time-frequency representations of neural signals.

Brain oscillations most often occur in bursts, called oscillation packets, which span a finite extent in time and frequency. Recent studies have shown that these packets portray a much more dynamic picture of synchronization and transient communication between sites than previously thought. To understand their nature and statistical properties, techniques are needed to objectively detect oscillation packets and to quantify their temporal and frequency extent, as well as their magnitude.

Geographical and varietal origin differentiation of alcoholic beverages through the association between FT-Raman spectroscopy and advanced data processing strategies.

The present work aimed to test the efficiency of FT-Raman spectroscopy for fruit spirits discrimination by developing differentiation models based on two approaches, namely a supervised statistical method (Partial Least Squares Discriminant Analysis), and a Machine Learning technique (Support Vector Machines). For this purpose, a data set comprising 86 Romanian distillate samples was used, which aimed to be differentiated in terms of the raw material used for production (plum, apple, pear and grape) and county of origin (Cluj, Satu Mare and Salaj). Eight distinct preprocessing methods (autoscale, mean center, variance scaling, smoothing, 1 derivative, 2 derivative, standard normal variate and Pareto) followed by a feature selection step were applied to identify the meaningful input data based on which the most efficient classification models can be constructed.

Highly cooperative chimeric super-SOX induces naive pluripotency across species.

Our understanding of pluripotency remains limited: iPSC generation has only been established for a few model species, pluripotent stem cell lines exhibit inconsistent developmental potential, and germline transmission has only been demonstrated for mice and rats. By swapping structural elements between Sox2 and Sox17, we built a chimeric super-SOX factor, Sox2-17, that enhanced iPSC generation in five tested species: mouse, human, cynomolgus monkey, cow, and pig. A swap of alanine to valine at the interface between Sox2 and Oct4 delivered a gain of function by stabilizing Sox2/Oct4 dimerization on DNA, enabling generation of high-quality OSKM iPSCs capable of supporting the development of healthy all-iPSC mice.

Satisfied on our own, yet ready to leave together: An actor-partner interdependence mediation model on job satisfaction and turnover intentions in leader-follower dyads.

Drawing on conservation of resources theory and job embeddedness, this study aims to investigate crossovers of positivity and negativiy between leaders and their followers with respect to work-related variables (i.e. work engagement, emotional exhaustion, job satisfaction and turnover intentions).

Decavanadate-Bearing Guanidine Derivatives Developed as Antimicrobial and Antitumor Species.

To obtain biologically active species, a series of decavanadates (Hpbg)[HVO]·6HO () (Htbg)[HVO]·6HO; () (Hgnd)(Hgnu)[VO]; () (Hgnu)[VO]·2HO; and () (pbg = 1-phenyl biguanide, tbg = 1-(-tolyl)biguanide, gnd = guanidine, and gnu = guanylurea) were synthesized and characterized by several spectroscopic techniques (IR, UV-Vis, and EPR) as well as by single crystal X-ray diffraction. Compound () crystallizes in space group -1 while () and () adopt the same centrosymmetric space group 21/n. The unusual signal identified by EPR spectroscopy was assigned to a charge-transfer π(O)→d(V) process.

Real-World Data on Second-Line Therapy with Ramucirumab for Metastatic Gastric Cancer: A Two-Center Study on Romanian Population.

(1) Background: Following the results of RAINBOW and REGARD trials, ramucirumab was approved as the standard second-line treatment for patients with advanced or metastatic gastric or gastroesophageal junction (GEJ) cancer, alone or in combination with paclitaxel. The present study aimed to evaluate the efficacy and safety of ramucirumab in the Romanian population during every-day clinical practice. (2) Methods: A two-center, retrospective, observational study evaluated patients with metastatic gastric and GEJ cancer treated with ramucirumab monotherapy or associated with paclitaxel.

Some Unmodified Household Adsorbents for the Adsorption of Benzalkonium Chloride-A Kinetic and Thermodynamic Case Study for Commercially Available Paper.

The extensive use of biocide surfactant benzalkonium chloride (BAC) during the SARS-CoV-2 pandemic has led to the buildup of this hazardous chemical in waste, surface and groundwater. e The study aims to elucidate whether various low-cost household materials are suitable, in their unmodified and untreated form, to effectively adsorb BAC from its aqueous solutions..

Effects of Lanthanum Substitution and Annealing on Structural, Morphologic, and Photocatalytic Properties of Nickel Ferrite.

Nanoparticles of NiLaFeO ferrite spinel incorporated in a SiO matrix were synthesized via a sol-gel method, followed by annealing at 200, 500, and 800 °C. The resulting materials were characterized via XRD, AFM, and BET techniques and evaluated for photocatalytic activity. The XRD diffractograms validate the formation of a single-phase cubic spinel structure at all temperatures, without any evidence of secondary peaks.

Correlation of Elemental Transfer, Bioactive Compounds and Antioxidant Activity on L. Grown in Soil with Functionalized CNT and HMs.

While heavy metals (HM) have been considered in recent decades to be the most common and problematic pollutants, the expansion of the list of pollutants due to the active use of carbon nanotubes (CNT) raises new questions about the benefit and harm of HM released to nature individually or fixed on CNT walls. A pot experiment was conducted to compare the effect of two classes of potential pollutants-metal salts of Pb, Mn, Cu, Zn, Cd, and Ni; and functionalized CNTs with COOH, MnO, FeO, and MnO-FeO-applied in soil, on the elemental transfer, the bioactive compounds accumulation, and the antioxidant activity in lettuce. While CNTs mainly increased the elemental transfer from soil to leaves, HM salts strongly obstructed it.

The Relation between Cognitive and Emotional Processes in Children and Adolescents with Neurodevelopmental Disorders-A Meta-Analysis.

Background: Up to 80% of children with autism spectrum disorders (ASDs) have mental health issues-either emotional or behavioral problems. The underlying mechanisms are still unknown, even if emotional regulation (ER) is considered to play a major role in child and adolescent psychopathology. Several studies link the ability to regulate the intensity and quality of emotions with executive functioning.

Multivariate study of lice (Insecta: Psocodea: Phthiraptera) assemblages hosted by hummingbirds (Aves: Trochilidae).

Lice were collected from 579 hummingbirds, representing 49 species, in 19 locations in Brazil, Costa Rica, Honduras, Paraguay and Peru, at elevations 0–3000 m above sea level. The following variables were included in an ecological analysis (1) host species' mean body mass, sexual size dimorphism, sexual dichromatism, migratory behaviour and dominance behaviour; (2) mean elevation, mean and predictability of temperature, mean and predictability of precipitation of the host species' geographic area; (3) prevalence and mean abundance of species of lice as measures of infestation. Ordination methods were applied to evaluate data structure.

Modelling the dispersion of particulate matter (PM) via wind erosion from opencast mining-Moldova Nouă tailings ponds, Romania.

Historically, Romania is known as a mining site of mineral substances, including gold, silver, copper, lead, zin, uranium, manganese, salt, and coal, whereby their long periods of exploitation and extraction affected human health and the environment in various ways. In Moldova Nouă southwest region of Romania, we investigated the environmental impacts of mining activities on air quality over 2021. We quantified PM emission rates through in situ monitoring, dispersion modelling, and horizontal and vertical fluxes.